eprintid: 10171274 rev_number: 13 eprint_status: archive userid: 699 dir: disk0/10/17/12/74 datestamp: 2023-06-05 14:06:55 lastmod: 2023-06-12 16:24:19 status_changed: 2023-06-12 16:22:51 type: article metadata_visibility: show sword_depositor: 699 creators_name: Fişek, Mehmet creators_name: Herrmann, Dustin creators_name: Egea-Weiss, Alexander creators_name: Cloves, Matilda creators_name: Bauer, Lisa creators_name: Lee, Tai-Ying creators_name: Russell, Lloyd E creators_name: Häusser, Michael title: Cortico-cortical feedback engages active dendrites in visual cortex ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G95 keywords: Mice, Animals, Feedback, Calcium, Neurons, Dendrites, Visual Cortex, Visual Pathways note: This paper was originally published under a standard Springer Nature license (© The Author(s), under exclusive licence to Springer Nature Limited). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the HTML and PDF versions of the article. abstract: Sensory processing in the neocortex requires both feedforward and feedback information flow between cortical areas 1. In feedback processing, higher-level representations provide contextual information to lower levels, and facilitate perceptual functions such as contour integration and figure–ground segmentation 2,3. However, we have limited understanding of the circuit and cellular mechanisms that mediate feedback influence. Here we use long-range all-optical connectivity mapping in mice to show that feedback influence from the lateromedial higher visual area (LM) to the primary visual cortex (V1) is spatially organized. When the source and target of feedback represent the same area of visual space, feedback is relatively suppressive. By contrast, when the source is offset from the target in visual space, feedback is relatively facilitating. Two-photon calcium imaging data show that this facilitating feedback is nonlinearly integrated in the apical tuft dendrites of V1 pyramidal neurons: retinotopically offset (surround) visual stimuli drive local dendritic calcium signals indicative of regenerative events, and two-photon optogenetic activation of LM neurons projecting to identified feedback-recipient spines in V1 can drive similar branch-specific local calcium signals. Our results show how neocortical feedback connectivity and nonlinear dendritic integration can together form a substrate to support both predictive and cooperative contextual interactions. date: 2023-05-25 date_type: published publisher: Springer Science and Business Media LLC official_url: https://doi.org/10.1038/s41586-023-06007-6 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2022598 doi: 10.1038/s41586-023-06007-6 medium: Print-Electronic pii: 10.1038/s41586-023-06007-6 lyricists_name: Hausser, Michael lyricists_name: Herrmann, Dustin lyricists_id: MHAUS91 lyricists_id: DHERR86 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: public publication: Nature volume: 617 number: 7962 pagerange: 769-776 event_location: England citation: Fişek, Mehmet; Herrmann, Dustin; Egea-Weiss, Alexander; Cloves, Matilda; Bauer, Lisa; Lee, Tai-Ying; Russell, Lloyd E; Fişek, Mehmet; Herrmann, Dustin; Egea-Weiss, Alexander; Cloves, Matilda; Bauer, Lisa; Lee, Tai-Ying; Russell, Lloyd E; Häusser, Michael; - view fewer <#> (2023) Cortico-cortical feedback engages active dendrites in visual cortex. Nature , 617 (7962) pp. 769-776. 10.1038/s41586-023-06007-6 <https://doi.org/10.1038/s41586-023-06007-6>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10171274/1/Herrmann_Cortico-cortical%20feedback%20engages%20active%20dendrites%20in%20visual%20cortex_AAM.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10171274/7/s41586-023-06007-6.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10171274/8/s41586-023-06241-y.pdf