eprintid: 10171238
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/17/12/38
datestamp: 2023-06-06 08:48:03
lastmod: 2023-06-06 08:48:03
status_changed: 2023-06-06 08:48:03
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Das, Soutrick
creators_name: Bulk, Debashis
title: Qualitative and quantitative nature of mutual interactions dictate chemical noise in a democratic reaction network
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
keywords: Science & Technology, Physical Sciences, Physics, Fluids & Plasmas, Physics, Mathematical, Physics, STOCHASTIC GENE-EXPRESSION, TO-CELL VARIABILITY, REGULATORY NETWORKS, FLUCTUATIONS, PROPAGATION, ULTRASENSITIVITY, DIFFERENTIATION, ATTENUATION, ORIGINS, ROLES
note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: The functions of a living cell rely on a complex network of biochemical reactions that allow it to respond against various internal and external cues. The outcomes of these chemical reactions are often stochastic due to intrinsic and extrinsic noise leading to population heterogeneity. The majority of calculations of stochasticity in reaction networks have focused on small regulatory networks addressing the role of timescales, feedback regulations, and network topology in propagation of noise. Here we computationally investigated chemical noise in a network with democratic architecture where each node is regulated by all other nodes in the network. We studied the effects of the qualitative and quantitative nature of mutual interactions on the propagation of both intrinsic and extrinsic noise in the network. We show that an increased number of inhibitory signals lead to ultrasensitive switching of average and that leads to sharp transition of intrinsic noise. The intrinsic noise exhibits a biphasic power-law scaling with the average, and the scaling coefficients strongly correlate with the strength of inhibitory signal. The noise strength critically depends on the strength of the interactions, where negative interactions attenuate both intrinsic and extrinsic noise.
date: 2020-04-17
date_type: published
publisher: AMER PHYSICAL SOC
official_url: https://doi.org/10.1103/PhysRevE.101.042407
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2024888
doi: 10.1103/PhysRevE.101.042407
medium: Print
lyricists_name: Das, Soutrick
lyricists_id: SDASA22
actors_name: Das, Soutrick
actors_id: SDASA22
actors_role: owner
funding_acknowledgements: EMR/2015/001899 [Science and Engineering Research Board, Department of Science and Technology (India)]; [INSPIRE program of the Department of Science and Technology, India]
full_text_status: public
publication: Physical Review E
volume: 101
number: 4
article_number: 042407
pages: 14
event_location: United States
issn: 2470-0045
citation:        Das, Soutrick;    Bulk, Debashis;      (2020)    Qualitative and quantitative nature of mutual interactions dictate chemical noise in a democratic reaction network.                   Physical Review E , 101  (4)    , Article 042407.  10.1103/PhysRevE.101.042407 <https://doi.org/10.1103/PhysRevE.101.042407>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10171238/1/PhysRevE.101.042407.pdf