TY  - JOUR
VL  - 101
N2  - The functions of a living cell rely on a complex network of biochemical reactions that allow it to respond against various internal and external cues. The outcomes of these chemical reactions are often stochastic due to intrinsic and extrinsic noise leading to population heterogeneity. The majority of calculations of stochasticity in reaction networks have focused on small regulatory networks addressing the role of timescales, feedback regulations, and network topology in propagation of noise. Here we computationally investigated chemical noise in a network with democratic architecture where each node is regulated by all other nodes in the network. We studied the effects of the qualitative and quantitative nature of mutual interactions on the propagation of both intrinsic and extrinsic noise in the network. We show that an increased number of inhibitory signals lead to ultrasensitive switching of average and that leads to sharp transition of intrinsic noise. The intrinsic noise exhibits a biphasic power-law scaling with the average, and the scaling coefficients strongly correlate with the strength of inhibitory signal. The noise strength critically depends on the strength of the interactions, where negative interactions attenuate both intrinsic and extrinsic noise.
AV  - public
EP  - 14
JF  - Physical Review E
N1  - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions.
SN  - 2470-0045
ID  - discovery10171238
KW  - Science & Technology
KW  -  Physical Sciences
KW  -  Physics
KW  -  Fluids & Plasmas
KW  -  Physics
KW  -  Mathematical
KW  -  Physics
KW  -  STOCHASTIC GENE-EXPRESSION
KW  -  TO-CELL VARIABILITY
KW  -  REGULATORY NETWORKS
KW  -  FLUCTUATIONS
KW  -  PROPAGATION
KW  -  ULTRASENSITIVITY
KW  -  DIFFERENTIATION
KW  -  ATTENUATION
KW  -  ORIGINS
KW  -  ROLES
TI  - Qualitative and quantitative nature of mutual interactions dictate chemical noise in a democratic reaction network
UR  - https://doi.org/10.1103/PhysRevE.101.042407
Y1  - 2020/04/17/
PB  - AMER PHYSICAL SOC
A1  - Das, Soutrick
A1  - Bulk, Debashis
IS  - 4
ER  -