eprintid: 10171020
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/17/10/20
datestamp: 2023-06-01 10:51:58
lastmod: 2023-06-01 10:51:58
status_changed: 2023-06-01 10:51:58
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Silventoinen, Karri
creators_name: Lahtinen, Hannu
creators_name: Korhonen, Kaarina
creators_name: Smith, George Davey
creators_name: Ripatti, Samuli
creators_name: Morris, Tim
creators_name: Martikainen, Pekka
title: Marital status and genetic liability independently predict coronary heart disease incidence
ispublished: inpress
divisions: UCL
divisions: B16
divisions: B14
divisions: J81
divisions: K26
keywords: Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, Marital status, coronary disease, genetics, socioeconomic factors
note: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
abstract: Aims: Married individuals have a lower coronary heart disease (CHD) risk than non-married, but the mechanisms behind this are not fully understood. We analyzed whether genetic liability to CHD may affect these associations. Methods: Marital status, a polygenic score of CHD (PGS-CHD), and other risk factors for CHD were measured from 35,444 participants (53% female) in Finnish population-based surveys conducted between 1992 and 2012. During the register-based follow-up until 2020, there were 2439 fatal and non-fatal incident CHD cases. The data were analyzed using linear and Cox regression models. Results: Divorced and cohabiting men and women had a higher genetic risk of CHD than married individuals, but the difference was very small (0.023–0.058 standard deviation of PGS-CHD, p-values 0.011–0.429). Both marital status and PGS-CHD were associated with CHD incidence, but the associations were largely independent. Adjusting for behavioral and metabolic risk factors for CHD explained part of these associations (11–20%). No interaction was found between marital status and PGS-CHD for CHD incidence. Conclusions: We showed minor differences between the marital status categories in PGS-CHD and demonstrated that marital status and genetic liability predicted CHD incidence largely independently. This emphasizes the need to measure multiple risk factors when predicting CHD risk.
date: 2022-09-07
date_type: published
publisher: SAGE PUBLICATIONS LTD
official_url: https://doi.org/10.1177/14034948221119634
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1977816
doi: 10.1177/14034948221119634
medium: Print-Electronic
lyricists_name: Morris, Tim
lyricists_id: TMORR75
actors_name: Morris, Tim
actors_id: TMORR75
actors_role: owner
funding_acknowledgements: 345219 [Academy of Finland]; 308247 [Academy of Finland]; 101019329 [European Research Council under the European Union]; MC_UU_00011/1 [UK Medical Research Council]
full_text_status: public
publication: Scandinavian Journal of Public Health
pages: 4
event_location: Sweden
issn: 1403-4948
citation:        Silventoinen, Karri;    Lahtinen, Hannu;    Korhonen, Kaarina;    Smith, George Davey;    Ripatti, Samuli;    Morris, Tim;    Martikainen, Pekka;      (2022)    Marital status and genetic liability independently predict coronary heart disease incidence.                   Scandinavian Journal of Public Health        10.1177/14034948221119634 <https://doi.org/10.1177/14034948221119634>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10171020/1/silventoinen-et-al-2022-marital-status-and-genetic-liability-independently-predict-coronary-heart-disease-incidence.pdf