<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10169637> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/title> "G protein-coupled receptor 158 modulates sensitivity to the sedative-hypnotic effect of ethanol in male mice"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Sensitivity to ethanol is used to assess a predisposition to recover from unconsciousness induced by excessive ethanol. The role of G protein-coupled receptor 158 (GPR158) in modulating sensitivity to the sedative-hypnotic effect of ethanol has not been investigated. METHODS: Loss of righting reflex (LORR) is a behavioral feature to indicate a state of hypnosis in rodents. In this study, Gpr158-/- mice and wild-type (WT) littermates (n = 8/genotype) were tested with the paradigms of LORR induced by a dose of 3.5 g/kg ethanol, open-field test (OFT) and blood ethanol concentration measurement. The OFT was used to examine the role of GPR158 in the ethanol effect on motor activity in Gpr158-/- mice (n = 6/genotype). Furthermore, CamK2A-Cre;Gpr158fl/fl (n = 9) and Vgat-Cre;Gpr158fl/fl mice (n = 10) went through LORR test and OFT compared to the controls (n= 9 and 8, respectively). RESULTS: Gpr158 deficiency led to a prolonged LORR duration by 110.6% (t14 = -5.241, p = 0.0001), without altering spontaneous activity (t14 = -0.718, p = 0.485) or ethanol metabolism (F1, 8 = 0.259, p = 0.625). Gpr158 knockout did not affect the ethanol effect on locomotion (F1, 10 = 0.262, p = 0.62). Furthermore, LORR duration became longer in the conditional knockouts of Gpr158 within calcium/calmodulin dependent protein kinase II alpha-positive (CamK2A+ ) neurons by 69% (t16 = -2.914, p = 0.01) and vesicular GABA transporter-positive (Vgat+ ) neurons by 92% (t9.802 = -2.519, p = 0.023), respectively, while locomotion was not altered in Camk2A-Cre;Gpr158fl/fl (t16 = 0.49, p = 0.631) or Vgat-Cre;Gpr158fl/fl mice (t16 = 0.035, p = 0.972). CONCLUSIONS: This study reveals a critical role of neuronal GPR158 in shaping sensitivity to the sedative-hypnotic effect of ethanol, suggesting that GPR158 may be a potential target for treating alcohol use disorder."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/date> "2023-07" .
<https://discovery.ucl.ac.uk/id/document/1579333> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/volume> "47" .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/issue> "7" .
<https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> <http://xmlns.com/foaf/0.1/name> "Wiley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> .
<https://discovery.ucl.ac.uk/id/publication/ext-01456008> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-01456008> <http://xmlns.com/foaf/0.1/name> "Alcohol: Clinical and Experimental Research"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-01456008> .
<https://discovery.ucl.ac.uk/id/publication/ext-01456008> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:01456008> .
<https://discovery.ucl.ac.uk/id/publication/ext-01456008> <http://purl.org/ontology/bibo/issn> "01456008" .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-22a38cc57d779b2bdd05de5f13ae5447> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-22a38cc57d779b2bdd05de5f13ae5447> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b27fdd66518656db07c2276b93e9996b> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-b27fdd66518656db07c2276b93e9996b> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c841b526857b16646ea38a028b67b444> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-c841b526857b16646ea38a028b67b444> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a2ad593c3bde147ee919934336408351> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-a2ad593c3bde147ee919934336408351> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8503a83ce4bdfa3634a62a79b477865c> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-8503a83ce4bdfa3634a62a79b477865c> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-96e7a1637f98ff27484c64f82f776234> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-96e7a1637f98ff27484c64f82f776234> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-39c823dba879c5e5ee59ba79b836fcf2> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-39c823dba879c5e5ee59ba79b836fcf2> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5ee74c44271b07d852d6878d7d942d0d> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-5ee74c44271b07d852d6878d7d942d0d> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-58ed90854b055b0393069cbe56503a32> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-58ed90854b055b0393069cbe56503a32> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-477773b1a6c7054e1e8335129b2ce12a> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-477773b1a6c7054e1e8335129b2ce12a> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8f52af835983969d4e8356d5700e399a> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-8f52af835983969d4e8356d5700e399a> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8e2235380815d9aad8d26c3005ad6dd6> .
<https://discovery.ucl.ac.uk/id/eprint/10169637> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10169637#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10169637#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-8e2235380815d9aad8d26c3005ad6dd6> .
<https://discovery.ucl.ac.uk/id/person/ext-477773b1a6c7054e1e8335129b2ce12a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-477773b1a6c7054e1e8335129b2ce12a> <http://xmlns.com/foaf/0.1/givenName> "Huiliang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-477773b1a6c7054e1e8335129b2ce12a> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-477773b1a6c7054e1e8335129b2ce12a> <http://xmlns.com/foaf/0.1/name> "Huiliang Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8503a83ce4bdfa3634a62a79b477865c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8503a83ce4bdfa3634a62a79b477865c> <http://xmlns.com/foaf/0.1/givenName> "Zhiyu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8503a83ce4bdfa3634a62a79b477865c> <http://xmlns.com/foaf/0.1/familyName> "Zhou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8503a83ce4bdfa3634a62a79b477865c> <http://xmlns.com/foaf/0.1/name> "Zhiyu Zhou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-22a38cc57d779b2bdd05de5f13ae5447> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-22a38cc57d779b2bdd05de5f13ae5447> <http://xmlns.com/foaf/0.1/givenName> "Shoupeng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-22a38cc57d779b2bdd05de5f13ae5447> <http://xmlns.com/foaf/0.1/familyName> "Wei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-22a38cc57d779b2bdd05de5f13ae5447> <http://xmlns.com/foaf/0.1/name> "Shoupeng Wei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8e2235380815d9aad8d26c3005ad6dd6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8e2235380815d9aad8d26c3005ad6dd6> <http://xmlns.com/foaf/0.1/givenName> "Ningning"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8e2235380815d9aad8d26c3005ad6dd6> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8e2235380815d9aad8d26c3005ad6dd6> <http://xmlns.com/foaf/0.1/name> "Ningning Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-96e7a1637f98ff27484c64f82f776234> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-96e7a1637f98ff27484c64f82f776234> <http://xmlns.com/foaf/0.1/givenName> "Huanquan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-96e7a1637f98ff27484c64f82f776234> <http://xmlns.com/foaf/0.1/familyName> "Liao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-96e7a1637f98ff27484c64f82f776234> <http://xmlns.com/foaf/0.1/name> "Huanquan Liao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58ed90854b055b0393069cbe56503a32> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-58ed90854b055b0393069cbe56503a32> <http://xmlns.com/foaf/0.1/givenName> "Xinjin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58ed90854b055b0393069cbe56503a32> <http://xmlns.com/foaf/0.1/familyName> "Chi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58ed90854b055b0393069cbe56503a32> <http://xmlns.com/foaf/0.1/name> "Xinjin Chi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5ee74c44271b07d852d6878d7d942d0d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5ee74c44271b07d852d6878d7d942d0d> <http://xmlns.com/foaf/0.1/givenName> "Xiaoma"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5ee74c44271b07d852d6878d7d942d0d> <http://xmlns.com/foaf/0.1/familyName> "Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5ee74c44271b07d852d6878d7d942d0d> <http://xmlns.com/foaf/0.1/name> "Xiaoma Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2ad593c3bde147ee919934336408351> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a2ad593c3bde147ee919934336408351> <http://xmlns.com/foaf/0.1/givenName> "Jian"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2ad593c3bde147ee919934336408351> <http://xmlns.com/foaf/0.1/familyName> "Jiang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2ad593c3bde147ee919934336408351> <http://xmlns.com/foaf/0.1/name> "Jian Jiang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c841b526857b16646ea38a028b67b444> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c841b526857b16646ea38a028b67b444> <http://xmlns.com/foaf/0.1/givenName> "Jinlong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c841b526857b16646ea38a028b67b444> <http://xmlns.com/foaf/0.1/familyName> "Chang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c841b526857b16646ea38a028b67b444> <http://xmlns.com/foaf/0.1/name> "Jinlong Chang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-39c823dba879c5e5ee59ba79b836fcf2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-39c823dba879c5e5ee59ba79b836fcf2> <http://xmlns.com/foaf/0.1/givenName> "Kun"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-39c823dba879c5e5ee59ba79b836fcf2> <http://xmlns.com/foaf/0.1/familyName> "Song"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-39c823dba879c5e5ee59ba79b836fcf2> <http://xmlns.com/foaf/0.1/name> "Kun Song"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b27fdd66518656db07c2276b93e9996b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b27fdd66518656db07c2276b93e9996b> <http://xmlns.com/foaf/0.1/givenName> "Lei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b27fdd66518656db07c2276b93e9996b> <http://xmlns.com/foaf/0.1/familyName> "Zheng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b27fdd66518656db07c2276b93e9996b> <http://xmlns.com/foaf/0.1/name> "Lei Zheng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8f52af835983969d4e8356d5700e399a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8f52af835983969d4e8356d5700e399a> <http://xmlns.com/foaf/0.1/givenName> "Xin"^^<http://www.w3.org/2001/XMLSchema#string> .
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