@article{discovery10169183,
          volume = {9},
            year = {2023},
           title = {Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity},
          number = {17},
            note = {Copyright {\copyright} 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).},
       publisher = {American Association for the Advancement of Science (AAAS)},
           month = {April},
         journal = {Science Advances},
            issn = {2375-2548},
        abstract = {Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure. Cis-Mendelian randomization (MR) was used to identify plasma proteins associating with CMR traits as well as with any of the following cardiac outcomes: HF, non-ischemic cardiomyopathy, dilated cardiomyopathy (DCM), atrial fibrillation, or coronary heart disease. In total, 33 plasma proteins were prioritized, including repurposing candidates for DCM and/or HF: IL18R (providing indirect evidence for IL18), I17RA, GPC5, LAMC2, PA2GA, CD33, and SLAF7. In addition, 13 of the 25 druggable proteins (52\%; 95\% confidence interval, 0.31 to 0.72) could be mapped to compounds with known oncological indications or side effects. These findings provide leads to facilitate drug development for cardiac disease and suggest that cardiotoxicities of several cancer treatments might represent mechanism-based adverse effects.},
          author = {Schmidt, Amand F and Bourfiss, Mimount and Alasiri, Abdulrahman and Puyol-Anton, Esther and Chopade, Sandesh and van Vugt, Marion and van der Laan, Sander W and Gross, Christian and Clarkson, Chris and Henry, Albert and Lumbers, Tom R and van der Harst, Pim and Franceschini, Nora and Bis, Joshua C and Velthuis, Birgitta K and Te Riele, Anneline SJM and Hingorani, Aroon D and Ruijsink, Bram and Asselbergs, Folkert W and van Setten, Jessica and Finan, Chris},
             url = {https://doi.org/10.1126/sciadv.add4984}
}