eprintid: 10168320 rev_number: 16 eprint_status: archive userid: 699 dir: disk0/10/16/83/20 datestamp: 2023-04-18 09:33:19 lastmod: 2023-09-04 10:38:34 status_changed: 2023-04-18 09:33:19 type: article metadata_visibility: show sword_depositor: 699 creators_name: Gollifer, Ruaridh M creators_name: Bray, Timothy JP creators_name: Kruezi, Ariona creators_name: Markus, Julia creators_name: Choida, Varvara creators_name: Hall-Craggs, Margaret A creators_name: Bainbridge, Alan title: A multiparametric alternative to short inversion-time inversion recovery for imaging inflammation: T2water and fat fraction measurement using chemical shift–encoded turbo spin-echo MRI ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 keywords: inflammation, magnetic resonance imaging, radiology note: © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/4.0/. abstract: Purpose: Short-inversion-time inversion-recovery MRI is used widely for imaging bone and soft-tissue inflammation in rheumatic inflammatory diseases, but there is no widely available quantitative equivalent of this sequence. This limits our ability to objectively assess inflammation and distinguish it from other processes. To address this, we investigate the use of the widely available Dixon turbo spin echo (TSE Dixon) sequence as a practical approach to simultaneous water-specific T2 (T2water) and fat fraction (FF) measurement.// Methods: We use a series of TSE Dixon acquisitions with varying effective TEs (TEeff) to quantify T2water and FF. The validity of this approach is assessed in a series of phantom and in vivo experiments, with reference values provided by Carr-Purcell-Meiboom-Gill acquisitions, MRS, and phantoms. The effect of inflammation on parameter values is evaluated in patients with spondyloarthritis.// Results: The T2water estimates obtained from TSE Dixon were accurate compared with the reference values from Carr-Purcell-Meiboom-Gill and spectroscopy in both fat-free environments and in the presence of fat. FF measurements with T2water correction from TSE Dixon were accurate from 0% to 60% FF and were not confounded by T2water variations. In vivo imaging produced good quality images that were artifact free, produced plausible T2 values, separating and quantifying the effect of inflammation on T2water and FF.// Conclusion: The T2water and FF measurements based on TSE Dixon with effective TE increments are accurate over a range of T2 and FF values and could provide a widely available quantitative alternative to the short-inversion-time inversion-recovery sequence for imaging inflamed tissue. date: 2023-06-01 date_type: published publisher: Wiley-Blackwell official_url: https://onlinelibrary.wiley.com/journal/15222594 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2016729 lyricists_name: Bray, Timothy lyricists_id: TBRAY81 actors_name: Bray, Timothy actors_id: TBRAY81 actors_role: owner funding_acknowledgements: CL-2019-18-001 [National Institute for Health Research]; [UCLH Biomedical Research Centre] full_text_status: public publication: Magnetic Resonance in Medicine volume: 90 number: 3 pagerange: 1010-1024 issn: 0740-3194 citation: Gollifer, Ruaridh M; Bray, Timothy JP; Kruezi, Ariona; Markus, Julia; Choida, Varvara; Hall-Craggs, Margaret A; Bainbridge, Alan; (2023) A multiparametric alternative to short inversion-time inversion recovery for imaging inflammation: T2water and fat fraction measurement using chemical shift–encoded turbo spin-echo MRI. Magnetic Resonance in Medicine , 90 (3) pp. 1010-1024. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10168320/8/Bray_Magnetic%20Resonance%20in%20Med%20-%202023%20-%20Gollifer.pdf