eprintid: 10167471
rev_number: 18
eprint_status: archive
userid: 699
dir: disk0/10/16/74/71
datestamp: 2023-03-30 10:05:39
lastmod: 2024-01-09 14:17:24
status_changed: 2023-08-23 14:33:27
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Goodlad, Cate
creators_name: Davenport, Andrew
title: The changing pattern of COVID-19 infection in haemodialysis and peritoneal dialysis patients
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
keywords: COVID-19, haemodialysis, hospitalisation, inflammation, peritoneal dialysis, survival
note: © 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
abstract: INTRODUCTION: Following the first wave of COVID-19 there have been several variants. We wished to review the number and severity of infections with the different variants in a population of haemodialysis (HD) and peritoneal dialysis (PD) patients. METHODS: We reviewed the outcomes and results in HD and PD patients testing positive for COVID-19 between March 2020 -August 2022. RESULTS: 795 cases of COVID-19 were recorded in 710 dialysis patients. More HD patients than PD contracted wild type (21.4 vs 6.8%), delta (23.3 vs 6.3%) and omicron (27.7 vs 14.7%), all p<0.01, but no difference with alpha (4.6 vs 6.3%) or beta variants (5.7 vs 6.85). Hospitalisation and death were greatest for alpha followed by wild type, beta, delta and omicron (60.6 vs 57 vs 47.5 vs 21.2 vs 19.3%) respectively, p<0.001. C reactive protein progressively increased from outpatient management to hospitalisation to hospitalisation with critical care or death (14 (4-30) vs 41 (18-101) vs 94 (47-168) mg/L, p<0.001. Despite previous infection and vaccination 85 (12%) patients had 2 or more infections with COVID-19. CONCLUSION: Disease severity declined and survival improved as the virus mutated from wild type and alpha to beta, delta and omicron variants. Whether this related to reduction in viral virulence, vaccination, natural acquired immunity, or introduction of pharmacological treatments remains to be determined. Government lockdowns and enhanced infection control measures reduced the % of HD patients contracting alpha and beta variants to those of PD. Vaccination and prior infection did not prevent re-infection.
date: 2023-07
date_type: published
publisher: Wiley
official_url: https://doi.org/10.1111/aor.14526
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2012675
doi: 10.1111/aor.14526
medium: Print-Electronic
lyricists_name: Davenport, Andrew
lyricists_id: ADAVE78
actors_name: Davenport, Andrew
actors_name: Henderson, Kathryn
actors_id: ADAVE78
actors_id: KJHEN38
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Artificial Organs
volume: 47
number: 7
pagerange: 1202-1207
event_location: United States
citation:        Goodlad, Cate;    Davenport, Andrew;      (2023)    The changing pattern of COVID-19 infection in haemodialysis and peritoneal dialysis patients.                   Artificial Organs , 47  (7)   pp. 1202-1207.    10.1111/aor.14526 <https://doi.org/10.1111/aor.14526>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10167471/8/Davenport_%20The%20changing%20pattern%20of%20COVID-19%20infection%20in%20haemodialysis%20and%20peritoneal%20dialysis%20patients_VoR.pdf