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<https://discovery.ucl.ac.uk/id/eprint/10166324> <http://purl.org/ontology/bibo/abstract> "Optimal treatment of locally advanced cervical cancer involves chemo radiation and image guided \r\nbrachytherapy. Technological advances with image guidance have improved the therapeutic ratio, \r\nenabling more accurate dose delivery to the target volume and sparing organs at risk. Achieving doses \r\nof > 85Gy to the high-risk clinical target volume results in 3-year local control rates of 86-94%. Strict \r\nplanning criteria for organs at risk are established to prevent long term toxicity and morbidity. Ureters \r\nare a structure in the pelvis in close relation to the cervix which are not routinely contoured as organs \r\nat risk, doses are not recorded, and no optimization constraints exist despite the significant risk of \r\nradiation induced ureteric stenosis.\r\nTo date very little cohesive data exist on the effect of radiation to the ureters during radical \r\nradiotherapy for cervical cancer. I have performed a comprehensive systematic review to summarise \r\nthe existing data on this subject and to identify important risk factors. I have also produced a step by \r\nstep pictorial atlas in conjunction with gynae radiologists to aid ureter identification and delineation \r\nand assessed its use. Once a method for contouring ureters was established, I retrospectively \r\ncontoured ureters on brachytherapy MRI images to allow a novel dosimetric analysis of dose to ureters \r\nduring cervical brachytherapy. I also investigated the feasibility of ureter dose optimisation during \r\ncervical brachytherapy. Finally, I assessed the dose to ureters and other organs at risk during RapidArc \r\nexternal beam radiotherapy and proton beam therapy, to establish if any therapeutic advantages can \r\nbe gained."^^<http://www.w3.org/2001/XMLSchema#string> .
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