<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10166206> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/title> "Plasma biomarkers of endothelial function, inflammation and oxidative stress in individuals with non-freezing cold injury"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/abstract> "Plasma biomarkers of inflammation, oxidative stress, endothelial function and damage were examined in 16 individuals with chronic NFCI (NFCI) and matched control participants with (COLD, n = 17) or without (CON, n = 14) previous cold exposure. Venous blood samples were collected at baseline to assess plasma biomarkers of endothelial function (nitrate, nitrite and endothelin-1), inflammation [interleukin-6 (IL-6), interleukin-10 (IL-10), tumour necrosis factor alpha and E-selectin], oxidative stress [protein carbonyl, 4-hydroxy-2-nonenal (4-HNE), superoxide dismutase and nitrotyrosine) and endothelial damage [von Willebrand factor, syndecan-1 and tissue type plasminogen activator (TTPA)]. Immediately after whole-body heating and separately, foot cooling, blood samples were taken for measurement of plasma [nitrate], [nitrite], [endothelin-1], [IL-6], [4-HNE] and [TTPA]. At baseline, [IL-10] and [syndecan-1] were increased in NFCI (P < 0.001 and P = 0.015, respectively) and COLD (P = 0.033 and P = 0.030, respectively) compared with CON participants. The [4-HNE] was elevated in CON compared with both NFCI (P = 0.002) and COLD (P < 0.001). [Endothelin-1] was elevated in NFCI compared with COLD (P < 0.001) post-heating. The [4-HNE] was lower in NFCI compared with CON post-heating (P = 0.032) and lower than both COLD (P = 0.02) and CON (P = 0.015) post-cooling. No between-group differences were seen for the other biomarkers. Mild to moderate chronic NFCI does not appear to be associated with a pro-inflammatory state or oxidative stress. Baseline [IL-10] and [syndecan-1] and post-heating [endothelin-1] are the most promising candidates for diagnosing NFCI, but it is likely that a combination of tests will be required."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/date> "2023-03-01" .
<https://discovery.ucl.ac.uk/id/document/1525145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/volume> "108" .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/issue> "3" .
<https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> <http://xmlns.com/foaf/0.1/name> "Wiley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-e7795bc59c66fd1972aa29b4459edb20> .
<https://discovery.ucl.ac.uk/id/publication/ext-09580670> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-09580670> <http://xmlns.com/foaf/0.1/name> "Experimental Physiology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-09580670> .
<https://discovery.ucl.ac.uk/id/publication/ext-09580670> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:09580670> .
<https://discovery.ucl.ac.uk/id/publication/ext-09580670> <http://purl.org/ontology/bibo/issn> "09580670" .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b856840433cebd3a109a1dd53981bc5b> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-b856840433cebd3a109a1dd53981bc5b> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-58e7f62e6edf633c394f2f075e321967> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-58e7f62e6edf633c394f2f075e321967> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-75be7d16fcf0aed3c8ed030312b63f5d> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-75be7d16fcf0aed3c8ed030312b63f5d> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4c6b7443a9b41b91ba8681bcf1fae603> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-4c6b7443a9b41b91ba8681bcf1fae603> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-71bba34e1747f03a918437c5eaa2368e> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-71bba34e1747f03a918437c5eaa2368e> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1c0293a960aa0739bc04abfb5db3fd58> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-1c0293a960aa0739bc04abfb5db3fd58> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a096a4a8a60355631893bbeaa0c0e11c> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-a096a4a8a60355631893bbeaa0c0e11c> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1b1b5ef146e7bc6eff9089771f8a78f9> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-1b1b5ef146e7bc6eff9089771f8a78f9> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-de8adf2a4e6a2b3c3ecf46d2dfb12fdb> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-de8adf2a4e6a2b3c3ecf46d2dfb12fdb> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6c0bff7921886fdbe11867606f72153a> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-6c0bff7921886fdbe11867606f72153a> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3b2c9ed600efc1e38445ca4d822418aa> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3b2c9ed600efc1e38445ca4d822418aa> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7fe8414e5340302606e2adc7c25a5c04> .
<https://discovery.ucl.ac.uk/id/eprint/10166206> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10166206#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10166206#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-7fe8414e5340302606e2adc7c25a5c04> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6b7443a9b41b91ba8681bcf1fae603> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6b7443a9b41b91ba8681bcf1fae603> <http://xmlns.com/foaf/0.1/givenName> "Heather"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6b7443a9b41b91ba8681bcf1fae603> <http://xmlns.com/foaf/0.1/familyName> "Massey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6b7443a9b41b91ba8681bcf1fae603> <http://xmlns.com/foaf/0.1/name> "Heather Massey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a096a4a8a60355631893bbeaa0c0e11c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a096a4a8a60355631893bbeaa0c0e11c> <http://xmlns.com/foaf/0.1/givenName> "John S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a096a4a8a60355631893bbeaa0c0e11c> <http://xmlns.com/foaf/0.1/familyName> "Young"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a096a4a8a60355631893bbeaa0c0e11c> <http://xmlns.com/foaf/0.1/name> "John S Young"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-71bba34e1747f03a918437c5eaa2368e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-71bba34e1747f03a918437c5eaa2368e> <http://xmlns.com/foaf/0.1/givenName> "Sarah"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-71bba34e1747f03a918437c5eaa2368e> <http://xmlns.com/foaf/0.1/familyName> "Hollis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-71bba34e1747f03a918437c5eaa2368e> <http://xmlns.com/foaf/0.1/name> "Sarah Hollis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0293a960aa0739bc04abfb5db3fd58> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0293a960aa0739bc04abfb5db3fd58> <http://xmlns.com/foaf/0.1/givenName> "Jonathan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0293a960aa0739bc04abfb5db3fd58> <http://xmlns.com/foaf/0.1/familyName> "Towse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0293a960aa0739bc04abfb5db3fd58> <http://xmlns.com/foaf/0.1/name> "Jonathan Towse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b856840433cebd3a109a1dd53981bc5b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b856840433cebd3a109a1dd53981bc5b> <http://xmlns.com/foaf/0.1/givenName> "Clare M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b856840433cebd3a109a1dd53981bc5b> <http://xmlns.com/foaf/0.1/familyName> "Eglin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b856840433cebd3a109a1dd53981bc5b> <http://xmlns.com/foaf/0.1/name> "Clare M Eglin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58e7f62e6edf633c394f2f075e321967> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-58e7f62e6edf633c394f2f075e321967> <http://xmlns.com/foaf/0.1/givenName> "Jennifer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58e7f62e6edf633c394f2f075e321967> <http://xmlns.com/foaf/0.1/familyName> "Wright"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58e7f62e6edf633c394f2f075e321967> <http://xmlns.com/foaf/0.1/name> "Jennifer Wright"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7fe8414e5340302606e2adc7c25a5c04> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7fe8414e5340302606e2adc7c25a5c04> <http://xmlns.com/foaf/0.1/givenName> "Michael J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7fe8414e5340302606e2adc7c25a5c04> <http://xmlns.com/foaf/0.1/familyName> "Tipton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7fe8414e5340302606e2adc7c25a5c04> <http://xmlns.com/foaf/0.1/name> "Michael J Tipton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-75be7d16fcf0aed3c8ed030312b63f5d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-75be7d16fcf0aed3c8ed030312b63f5d> <http://xmlns.com/foaf/0.1/givenName> "Anthony I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-75be7d16fcf0aed3c8ed030312b63f5d> <http://xmlns.com/foaf/0.1/familyName> "Shepherd"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-75be7d16fcf0aed3c8ed030312b63f5d> <http://xmlns.com/foaf/0.1/name> "Anthony I Shepherd"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3b2c9ed600efc1e38445ca4d822418aa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3b2c9ed600efc1e38445ca4d822418aa> <http://xmlns.com/foaf/0.1/givenName> "Hugh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3b2c9ed600efc1e38445ca4d822418aa> <http://xmlns.com/foaf/0.1/familyName> "Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3b2c9ed600efc1e38445ca4d822418aa> <http://xmlns.com/foaf/0.1/name> "Hugh Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6c0bff7921886fdbe11867606f72153a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6c0bff7921886fdbe11867606f72153a> <http://xmlns.com/foaf/0.1/givenName> "Chris"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6c0bff7921886fdbe11867606f72153a> <http://xmlns.com/foaf/0.1/familyName> "Wilkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6c0bff7921886fdbe11867606f72153a> <http://xmlns.com/foaf/0.1/name> "Chris Wilkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b1b5ef146e7bc6eff9089771f8a78f9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1b1b5ef146e7bc6eff9089771f8a78f9> <http://xmlns.com/foaf/0.1/givenName> "Matthew J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b1b5ef146e7bc6eff9089771f8a78f9> <http://xmlns.com/foaf/0.1/familyName> "Maley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b1b5ef146e7bc6eff9089771f8a78f9> <http://xmlns.com/foaf/0.1/name> "Matthew J Maley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de8adf2a4e6a2b3c3ecf46d2dfb12fdb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-de8adf2a4e6a2b3c3ecf46d2dfb12fdb> <http://xmlns.com/foaf/0.1/givenName> "Stephen J"^^<http://www.w3.org/2001/XMLSchema#string> .
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