TY - JOUR AV - public KW - Science & Technology KW - Life Sciences & Biomedicine KW - Clinical Neurology KW - Neurosciences KW - Neurosciences & Neurology KW - RECEPTOR KW - ANTIBODY ID - discovery10166171 N1 - © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. EP - 1250 JF - Annals of Neurology SN - 0364-5134 PB - WILEY VL - 88 IS - 6 SP - 1244 N2 - This study aimed to characterise both neuronal autoantibodies and levels of interferon ?, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively, p < 0.0001). In summary, neuronal-surface reactive antibodies were not detected in NPSLE. Further, while interferon ? levels were higher in SLE (p < 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020;88:1244?1250. UR - https://doi.org/10.1002/ana.25908 A1 - Varley, James A A1 - Andersson, Magnus A1 - Grant, Eleanor A1 - Berretta, Antonio A1 - Zandi, Michael S A1 - Bondet, Vincent A1 - Duffy, Darragh A1 - Hunt, David A1 - Piehl, Fredrik A1 - Waters, Patrick A1 - Irani, Sarosh R Y1 - 2020/12/01/ TI - Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus ER -