TY  - JOUR
AV  - public
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Clinical Neurology
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  RECEPTOR
KW  -  ANTIBODY
ID  - discovery10166171
N1  - © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EP  - 1250
JF  - Annals of Neurology
SN  - 0364-5134
PB  - WILEY
VL  - 88
IS  - 6
SP  - 1244
N2  - This study aimed to characterise both neuronal autoantibodies and levels of interferon ?, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively, p < 0.0001). In summary, neuronal-surface reactive antibodies were not detected in NPSLE. Further, while interferon ? levels were higher in SLE (p < 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020;88:1244?1250.
UR  - https://doi.org/10.1002/ana.25908
A1  - Varley, James A
A1  - Andersson, Magnus
A1  - Grant, Eleanor
A1  - Berretta, Antonio
A1  - Zandi, Michael S
A1  - Bondet, Vincent
A1  - Duffy, Darragh
A1  - Hunt, David
A1  - Piehl, Fredrik
A1  - Waters, Patrick
A1  - Irani, Sarosh R
Y1  - 2020/12/01/
TI  - Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus
ER  -