TY  - JOUR
TI  - Head shaking does not alter vestibulo ocular reflex gain in vestibular migraine
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Clinical Neurology
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  vestibular migraine
KW  -  vestibulo ocular reflex
KW  -  head shake
KW  -  motion sensitivity
KW  -  vHIT
KW  -  MOTION SICKNESS
KW  -  NYSTAGMUS
KW  -  VERTIGO
UR  - https://doi.org/10.3389/fneur.2022.967521
JF  - Frontiers in Neurology
EP  - 6
AV  - public
ID  - discovery10166111
N1  - © 2022 Patel, Castro, Koohi, Arshad,
Gargallo, Carmona and Kaski. This is
an open-access article distributed
under the terms of the Creative
Commons Attribution License (CC BY).
The use, distribution or reproduction
in other forums is permitted, provided
the original author(s) and the copyright
owner(s) are credited and that the
original publication in this journal is
cited, in accordance with accepted
academic practice. No use, distribution
or reproduction is permitted which
does not comply with these terms.
PB  - FRONTIERS MEDIA SA
VL  - 13
Y1  - 2022/09/30/
A1  - Patel, Priyani
A1  - Castro, Patricia
A1  - Koohi, Nehzat
A1  - Arshad, Qadeer
A1  - Gargallo, Lucia
A1  - Carmona, Sergio
A1  - Kaski, Diego
N2  - Vestibular Migraine (VM) is the most common cause of non-positional episodic vestibular symptoms. Patients with VM commonly report increased motion sensitivity, suggesting that vestibular responses to head movement may identify changes specific to VM patients. Here we explore whether the vestibulo-ocular reflex (VOR) gain alters in response to a clinical ?headshake? maneuver in patients with VM. Thirty patients with VM in the inter-ictal phase, 16 patients with Benign Positional Paroxysmal Vertigo (BPPV) and 15 healthy controls were recruited. Patients responded to the question ?Do you feel sick reading in the passenger seat of a car?? and completed a validated motion sickness questionnaire as a measure of motion sensitivity. Lateral canal vHIT testing was performed before and after headshaking; the change in VOR gain was calculated as the primary outcome. Baseline VOR gain was within normal limits across all participants. There was no significant change in VOR gain after headshaking in any group (p = 0.264). Patients were 4.3 times more likely to be in the VM group than in the BPPV group if they reported nausea when reading in the passenger seat of a car. We postulate that a headshake stimulus may be insufficient to disrupt cortical interactions and induce a change in VOR gain. Alternatively, changes in VOR gain may only be apparent in the acute phase of VM. Reading in the passenger seat of a car was considered uncomfortable in all VM patients suggesting that this specific question may be useful for the diagnosis of VM.
ER  -