TY  - JOUR
N2  - Our knowledge in vascular anomalies has grown tremendously in the past decade with the identification of key molecular pathways and genetic mutations that drive the development of vascular tumors and vascular malformations. This has led us to better understand the pathogenesis of vascular lesions, refine their diagnosis and update their classification while also exploring the opportunity for a targeted molecular treatment. This paper aims to provide an overview of venous malformations (VM) in childhood. Specific entities include common VMs, cutaneo-mucosal VM, blue rubber bleb nevus syndrome or Bean syndrome, glomuvenous malformation, cerebral cavernous malformation, familial intraosseous vascular malformation and verrucous venous malformation. The clinicopathological features and the molecular basis of each entity are reviewed.
SP  - 477
UR  - https://doi.org/10.3390/dermatopathology8040050
A1  - Colmenero, Isabel
A1  - Knöpfel, Nicole
Y1  - 2021/10/15/
TI  - Venous Malformations in Childhood: Clinical, Histopathological and Genetics Update
KW  - Genetics
KW  -  histopathology
KW  -  somatic and germline mutations
KW  -  targeted therapy
KW  -  vascular anomalies
KW  -  venous malformations
AV  - public
ID  - discovery10165667
EP  - 493
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
JF  - Dermatopathology
PB  - MDPI AG
VL  - 8
IS  - 4
ER  -