eprintid: 10165520 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/16/55/20 datestamp: 2023-02-24 13:03:22 lastmod: 2023-02-24 13:03:22 status_changed: 2023-02-24 13:03:22 type: article metadata_visibility: show sword_depositor: 699 creators_name: Xiong, Tianzhu creators_name: Li, Xueyan creators_name: Yago, Masaya creators_name: Mallet, James title: Admixture of evolutionary rates across a butterfly hybrid zone ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: F99 keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, hybridization, reproductive isolation, molecular clock, gene flow, Other, DIVERGENT SELECTION, MUTATION-RATE, GENE FLOW, HYBRIDIZATION, POPULATION, SPECIATION, REVEALS, ROAD note: Copyright © et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. abstract: Hybridization is a major evolutionary force that can erode genetic differentiation between species, whereas reproductive isolation maintains such differentiation. In studying a hybrid zone between the swallowtail butterflies Papilio syfanius and Papilio maackii (Lepidoptera: Papilionidae), we made the unexpected discovery that genomic substitution rates are unequal between the parental species. This phenomenon creates a novel process in hybridization, where genomic regions most affected by gene flow evolve at similar rates between species, while genomic regions with strong reproductive isolation evolve at species-specific rates. Thus, hybridization mixes evolutionary rates in a way similar to its effect on genetic ancestry. Using coalescent theory, we show that the rate-mixing process provides distinct information about levels of gene flow across different parts of genomes, and the degree of rate-mixing can be predicted quantitatively from relative sequence divergence (FST ) between the hybridizing species at equilibrium. Overall, we demonstrate that reproductive isolation maintains not only genomic differentiation, but also the rate at which differentiation accumulates. Thus, asymmetric rates of evolution provide an additional signature of loci involved in reproductive isolation. date: 2022-06-15 date_type: published publisher: eLIFE SCIENCES PUBL LTD official_url: https://doi.org/10.7554/eLife.78135 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1962700 doi: 10.7554/eLife.78135 medium: Electronic pii: 78135 lyricists_name: Mallet, James lyricists_id: JMALL47 actors_name: Mallet, James actors_id: JMALL47 actors_role: owner funding_acknowledgements: [American Philosophical Society]; 1764269 [NSF-Simons Center for Mathematical and Statistical Analysis of Biology]; [Quantitative Biology Initiative (Harvard University)]; [Department of Organismic and Evolutionary Biology, Harvard University] full_text_status: public publication: eLife volume: 11 article_number: e78135 pages: 31 event_location: England issn: 2050-084X citation: Xiong, Tianzhu; Li, Xueyan; Yago, Masaya; Mallet, James; (2022) Admixture of evolutionary rates across a butterfly hybrid zone. eLife , 11 , Article e78135. 10.7554/eLife.78135 <https://doi.org/10.7554/eLife.78135>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10165520/1/elife-78135-v2.pdf