eprintid: 10165520
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/16/55/20
datestamp: 2023-02-24 13:03:22
lastmod: 2023-02-24 13:03:22
status_changed: 2023-02-24 13:03:22
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Xiong, Tianzhu
creators_name: Li, Xueyan
creators_name: Yago, Masaya
creators_name: Mallet, James
title: Admixture of evolutionary rates across a butterfly hybrid zone
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F99
keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, hybridization, reproductive isolation, molecular clock, gene flow, Other, DIVERGENT SELECTION, MUTATION-RATE, GENE FLOW, HYBRIDIZATION, POPULATION, SPECIATION, REVEALS, ROAD
note: Copyright © et al. This
article is distributed under the
terms of the Creative Commons
Attribution License, which
permits unrestricted use and
redistribution provided that the
original author and source are
credited.
abstract: Hybridization is a major evolutionary force that can erode genetic differentiation between species, whereas reproductive isolation maintains such differentiation. In studying a hybrid zone between the swallowtail butterflies Papilio syfanius and Papilio maackii (Lepidoptera: Papilionidae), we made the unexpected discovery that genomic substitution rates are unequal between the parental species. This phenomenon creates a novel process in hybridization, where genomic regions most affected by gene flow evolve at similar rates between species, while genomic regions with strong reproductive isolation evolve at species-specific rates. Thus, hybridization mixes evolutionary rates in a way similar to its effect on genetic ancestry. Using coalescent theory, we show that the rate-mixing process provides distinct information about levels of gene flow across different parts of genomes, and the degree of rate-mixing can be predicted quantitatively from relative sequence divergence (FST ) between the hybridizing species at equilibrium. Overall, we demonstrate that reproductive isolation maintains not only genomic differentiation, but also the rate at which differentiation accumulates. Thus, asymmetric rates of evolution provide an additional signature of loci involved in reproductive isolation.
date: 2022-06-15
date_type: published
publisher: eLIFE SCIENCES PUBL LTD
official_url: https://doi.org/10.7554/eLife.78135
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1962700
doi: 10.7554/eLife.78135
medium: Electronic
pii: 78135
lyricists_name: Mallet, James
lyricists_id: JMALL47
actors_name: Mallet, James
actors_id: JMALL47
actors_role: owner
funding_acknowledgements: [American Philosophical Society]; 1764269 [NSF-Simons Center for Mathematical and Statistical Analysis of Biology]; [Quantitative Biology Initiative (Harvard University)]; [Department of Organismic and Evolutionary Biology, Harvard University]
full_text_status: public
publication: eLife
volume: 11
article_number: e78135
pages: 31
event_location: England
issn: 2050-084X
citation:        Xiong, Tianzhu;    Li, Xueyan;    Yago, Masaya;    Mallet, James;      (2022)    Admixture of evolutionary rates across a butterfly hybrid zone.                   eLife , 11     , Article e78135.  10.7554/eLife.78135 <https://doi.org/10.7554/eLife.78135>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10165520/1/elife-78135-v2.pdf