<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10165424> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/title> "Effect of nintedanib in patients with systemic sclerosis-associated interstitial lung disease and risk factors for rapid progression"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: To investigate the rate of decline in forced vital capacity (FVC), and the effect of nintedanib on the rate of decline in FVC, in subjects with systemic sclerosis-associated interstitial lung disease (SSc-ILD) who had risk factors for rapid decline in FVC. METHODS: The SENSCIS trial enrolled subjects with SSc and fibrotic ILD of ≥10% extent on high-resolution CT. The rate of decline in FVC over 52 weeks was analysed in all subjects and in those with early SSc (<18 months since first non-Raynaud symptom), elevated inflammatory markers (C reactive protein ≥6 mg/L and/or platelets ≥330×109/L) or significant skin fibrosis (modified Rodnan skin score (mRSS) 15-40 or mRSS ≥18) at baseline. RESULTS: In the placebo group, the rate of decline in FVC was numerically greater in subjects with <18 months since first non-Raynaud symptom (-167.8 mL/year), elevated inflammatory markers (-100.7 mL/year), mRSS 15-40 (-121.7 mL/year) or mRSS ≥18 (-131.7 mL/year) than in all subjects (-93.3 mL/year). Nintedanib reduced the rate of FVC decline across subgroups, with a numerically greater effect in patients with these risk factors for rapid FVC decline. CONCLUSION: In the SENSCIS trial, subjects with SSc-ILD who had early SSc, elevated inflammatory markers or extensive skin fibrosis had a more rapid decline in FVC over 52 weeks than the overall trial population. Nintedanib had a numerically greater effect in patients with these risk factors for rapid ILD progression."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/date> "2023-02-16" . <https://discovery.ucl.ac.uk/id/document/1523779> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/volume> "9" . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/org/ext-d7223ba9a97f887033fca24a24d100c4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-d7223ba9a97f887033fca24a24d100c4> <http://xmlns.com/foaf/0.1/name> "BMJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-d7223ba9a97f887033fca24a24d100c4> . <https://discovery.ucl.ac.uk/id/publication/ext-20565933> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-20565933> <http://xmlns.com/foaf/0.1/name> "RMD Open"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20565933> . <https://discovery.ucl.ac.uk/id/publication/ext-20565933> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20565933> . <https://discovery.ucl.ac.uk/id/publication/ext-20565933> <http://purl.org/ontology/bibo/issn> "20565933" . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-71f65f5651d9bd9362500be3779c552a> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-71f65f5651d9bd9362500be3779c552a> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8358e4e1109217816b75c5bc3ead60de> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-8358e4e1109217816b75c5bc3ead60de> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3989363f2e105ecc98eaaa7db5a4519e> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-3989363f2e105ecc98eaaa7db5a4519e> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-743cab37797b6de8664170a94eb4611e> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-743cab37797b6de8664170a94eb4611e> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-245629667a1005aae770ca6071015c8b> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-245629667a1005aae770ca6071015c8b> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-25a325782577133f24451475c4c1ffb9> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-25a325782577133f24451475c4c1ffb9> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-041dcc325b7ff19ed1ecdf4048273cb5> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-041dcc325b7ff19ed1ecdf4048273cb5> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d7bc54a9c55bd783d33de76608b570b0> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-d7bc54a9c55bd783d33de76608b570b0> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f0c5766c96b79f56f627e082ddd08cc2> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-f0c5766c96b79f56f627e082ddd08cc2> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-24a680e7373ee9d4a7d818fdb8b67d26> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-24a680e7373ee9d4a7d818fdb8b67d26> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3da846f36a9aaafc0e8ae7ec343bfed2> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3da846f36a9aaafc0e8ae7ec343bfed2> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8c619e2bbe8548e342e6c9d426c2d6a7> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-8c619e2bbe8548e342e6c9d426c2d6a7> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0e360ccfcab4c8124e83b2e574219c48> . <https://discovery.ucl.ac.uk/id/eprint/10165424> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> . <https://discovery.ucl.ac.uk/id/eprint/10165424#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-0e360ccfcab4c8124e83b2e574219c48> . <https://discovery.ucl.ac.uk/id/person/ext-743cab37797b6de8664170a94eb4611e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-743cab37797b6de8664170a94eb4611e> <http://xmlns.com/foaf/0.1/givenName> "Yannick"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-743cab37797b6de8664170a94eb4611e> <http://xmlns.com/foaf/0.1/familyName> "Allanore"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-743cab37797b6de8664170a94eb4611e> <http://xmlns.com/foaf/0.1/name> "Yannick Allanore"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-24a680e7373ee9d4a7d818fdb8b67d26> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-24a680e7373ee9d4a7d818fdb8b67d26> <http://xmlns.com/foaf/0.1/givenName> "Christian"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-24a680e7373ee9d4a7d818fdb8b67d26> <http://xmlns.com/foaf/0.1/familyName> "Stock"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-24a680e7373ee9d4a7d818fdb8b67d26> <http://xmlns.com/foaf/0.1/name> "Christian Stock"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7bc54a9c55bd783d33de76608b570b0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d7bc54a9c55bd783d33de76608b570b0> <http://xmlns.com/foaf/0.1/givenName> "Anna-Maria"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7bc54a9c55bd783d33de76608b570b0> <http://xmlns.com/foaf/0.1/familyName> "Hoffmann-Vold"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d7bc54a9c55bd783d33de76608b570b0> <http://xmlns.com/foaf/0.1/name> "Anna-Maria Hoffmann-Vold"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3989363f2e105ecc98eaaa7db5a4519e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3989363f2e105ecc98eaaa7db5a4519e> <http://xmlns.com/foaf/0.1/givenName> "Elizabeth R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3989363f2e105ecc98eaaa7db5a4519e> <http://xmlns.com/foaf/0.1/familyName> "Volkmann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3989363f2e105ecc98eaaa7db5a4519e> <http://xmlns.com/foaf/0.1/name> "Elizabeth R Volkmann"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3da846f36a9aaafc0e8ae7ec343bfed2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3da846f36a9aaafc0e8ae7ec343bfed2> <http://xmlns.com/foaf/0.1/givenName> "Margarida"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3da846f36a9aaafc0e8ae7ec343bfed2> <http://xmlns.com/foaf/0.1/familyName> "Alves"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3da846f36a9aaafc0e8ae7ec343bfed2> <http://xmlns.com/foaf/0.1/name> "Margarida Alves"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-25a325782577133f24451475c4c1ffb9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-25a325782577133f24451475c4c1ffb9> <http://xmlns.com/foaf/0.1/givenName> "Shervin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-25a325782577133f24451475c4c1ffb9> <http://xmlns.com/foaf/0.1/familyName> "Assassi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-25a325782577133f24451475c4c1ffb9> <http://xmlns.com/foaf/0.1/name> "Shervin Assassi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f0c5766c96b79f56f627e082ddd08cc2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f0c5766c96b79f56f627e082ddd08cc2> <http://xmlns.com/foaf/0.1/givenName> "Masataka"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f0c5766c96b79f56f627e082ddd08cc2> <http://xmlns.com/foaf/0.1/familyName> "Kuwana"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f0c5766c96b79f56f627e082ddd08cc2> <http://xmlns.com/foaf/0.1/name> "Masataka Kuwana"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0e360ccfcab4c8124e83b2e574219c48> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0e360ccfcab4c8124e83b2e574219c48> <http://xmlns.com/foaf/0.1/givenName> "Christopher P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0e360ccfcab4c8124e83b2e574219c48> <http://xmlns.com/foaf/0.1/familyName> "Denton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0e360ccfcab4c8124e83b2e574219c48> <http://xmlns.com/foaf/0.1/name> "Christopher P Denton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8c619e2bbe8548e342e6c9d426c2d6a7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8c619e2bbe8548e342e6c9d426c2d6a7> <http://xmlns.com/foaf/0.1/givenName> "Steven"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8c619e2bbe8548e342e6c9d426c2d6a7> <http://xmlns.com/foaf/0.1/familyName> "Sambevski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8c619e2bbe8548e342e6c9d426c2d6a7> <http://xmlns.com/foaf/0.1/name> "Steven Sambevski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-71f65f5651d9bd9362500be3779c552a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-71f65f5651d9bd9362500be3779c552a> <http://xmlns.com/foaf/0.1/givenName> "Dinesh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-71f65f5651d9bd9362500be3779c552a> <http://xmlns.com/foaf/0.1/familyName> "Khanna"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-71f65f5651d9bd9362500be3779c552a> <http://xmlns.com/foaf/0.1/name> "Dinesh Khanna"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8358e4e1109217816b75c5bc3ead60de> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8358e4e1109217816b75c5bc3ead60de> <http://xmlns.com/foaf/0.1/givenName> "Toby M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8358e4e1109217816b75c5bc3ead60de> <http://xmlns.com/foaf/0.1/familyName> "Maher"^^<http://www.w3.org/2001/XMLSchema#string> . 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