eprintid: 10164347
rev_number: 11
eprint_status: archive
userid: 699
dir: disk0/10/16/43/47
datestamp: 2023-03-16 16:17:04
lastmod: 2023-03-16 16:18:08
status_changed: 2023-03-16 16:17:04
type: thesis
metadata_visibility: show
sword_depositor: 699
creators_name: Clark, Maryam
title: Elucidating the mechanisms behind nucleogenesis of the avian auditory hindbrain: a focus on the nucleus Laminaris
ispublished: unpub
divisions: B02
divisions: D13
divisions: F96
divisions: G22
divisions: UCL
note: Copyright © The Author 2023. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
abstract: A major recurrent form of organisation in the vertebrate CNS are neuronal nuclei. During
early brain development, neural cells are generated and undergo a complex journey of
migration, adhesion and nucleus structural formation. Together, this process is known as nucleogenesis;
a process whose governing mechanisms are still poorly understood. Nonetheless,
failure to form stereotypical nuclei has been linked to heterotopia; a condition linked to multiple
neurological disorders, including epilepsy, autism spectrum disorder, Van Maldergem
syndrome, schizophrenia and more. This project utilises a number of interdisciplinary
techniques to elucidate the genetic and physical mechanisms that aid in the development
of the tertiary avian auditory nucleus, the nucleus Laminaris. A monolayered structure,
this project suggests that cadherin-involved control of neural progenitor cell exit from the
ventricular zone, neural cell shape and an autoregulatory signalling factor (FGF8), could be
important factors in its formation. Further, an adapted slice culture technique and multiple
demonstrations of its use present the future for further research into nucleogenesis of the nL.
date: 2023-02-28
date_type: published
oa_status: green
full_text_type: other
thesis_class: doctoral_open
thesis_award: Ph.D
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2003369
lyricists_name: Clark, Maryam
lyricists_id: MCLAR24
actors_name: Clark, Maryam
actors_id: MCLAR24
actors_role: owner
full_text_status: public
pages: 304
institution: UCL (University College London)
department: Cell and Developmental Biology
thesis_type: Doctoral
editors_name: Clark, Maryam
citation:        Clark, Maryam;      (2023)    Elucidating the mechanisms behind nucleogenesis of the avian auditory hindbrain: a focus on the nucleus Laminaris.                   Doctoral thesis  (Ph.D), UCL (University College London).     Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10164347/1/PhD%20thesis%20Maryam%20Clark%2027Nov22.pdf