<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10163952> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Thesis> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/terms/title> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/ontology/bibo/abstract> "Worldwide prevalence and severity of myopia have increased dramatically nowadays. High myopia and its irreversible associated eye elongation increase the risk of sight-threatening conditions. However, the exact mechanisms that drive myopia progression are \r\nstill unknown. Myopia almost exclusively occurs in childhood, suggesting the adult sclera is functionally different from the young sclera. During myopia progression, the sclera becomes thinner and more elastic, and the composition of its scleral extracellular matrix changes. Similarly, the choroid is thinner and accommodation-induced choroidal secreted factors are linked to tissue biomechanics that may regulate scleral remodelling and eye elongation. Thus, we hypothesize that signals from the choroid are crucial to the regulation of scleral biomechanics. In addition, light exposure and subsequent dopamine release may regulate scleral remodelling and eye elongation, and myopia development and progression could be \r\ninduced by near work. \r\n   We used human primary fibroblasts isolated from the sclera and choroid of donor eyes from different ages and antero-posterior positions to test our hypothesis. We found that paediatric scleral fibroblastsembedded in the 3D collagen gels had greater contractility than adult ones, particularly those from the anterior part of the sclera. Scleral fibroblasts’ ability to contract collagen gels was enhanced following stimulation with the choroid-conditioned medium, and this promotion was not due to an increase in proliferation or change in a-SMA expression. Furthermore, the ability of choroid \r\nconditioned medium to stimulate scleral fibroblasts was completely abolished when choroid cells were treated with dopamine. This suggests that normal scleral development is regulated by a balance \r\nbetween positive biochemical signals from the\r\nchoroid, and negative signals resulting from a direct effect of retina-derived dopamine on the choroid cells. These findings may help improve clinical practice to control myopia development and progression in the future."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/terms/date> "2023-01-28" .
<https://discovery.ucl.ac.uk/id/document/1521864> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://xmlns.com/foaf/0.1/name> "UCL (University College London)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/terms/issuer> <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> .
<https://discovery.ucl.ac.uk/id/org/ext-9960000b5a6e2d1fad68cabc17a5cb84> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-9960000b5a6e2d1fad68cabc17a5cb84> <http://xmlns.com/foaf/0.1/name> "Institute of Ophthalmology, UCL (University College London)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/org/ext-9960000b5a6e2d1fad68cabc17a5cb84> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/terms/issuer> <https://discovery.ucl.ac.uk/id/org/ext-9960000b5a6e2d1fad68cabc17a5cb84> .
<https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/org/ext-9960000b5a6e2d1fad68cabc17a5cb84> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/unpublished> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-280e1cae000216ca9dee3ac86b62e6d0> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10163952#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10163952#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-280e1cae000216ca9dee3ac86b62e6d0> .
<https://discovery.ucl.ac.uk/id/person/ext-280e1cae000216ca9dee3ac86b62e6d0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-280e1cae000216ca9dee3ac86b62e6d0> <http://xmlns.com/foaf/0.1/givenName> "Yuyi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-280e1cae000216ca9dee3ac86b62e6d0> <http://xmlns.com/foaf/0.1/familyName> "Ren"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-280e1cae000216ca9dee3ac86b62e6d0> <http://xmlns.com/foaf/0.1/name> "Yuyi Ren"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ThesisEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1521864> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1521864> <http://www.w3.org/2000/01/rdf-schema#label> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasSubmitted> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1521864> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10163952/2/MPhil%20Thesis%20-%20Yuyi%20Ren%2018031931.pdf> .
<https://discovery.ucl.ac.uk/id/document/1521864> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10163952/2/MPhil%20Thesis%20-%20Yuyi%20Ren%2018031931.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/2/MPhil%20Thesis%20-%20Yuyi%20Ren%2018031931.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "MPhil Thesis - Yuyi Ren 18031931.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1559143> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://www.w3.org/2000/01/rdf-schema#label> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10163952/3/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/document/1559143> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10163952/3/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/3/lightbox.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "lightbox.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1559144> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://www.w3.org/2000/01/rdf-schema#label> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10163952/4/preview.jpg> .
<https://discovery.ucl.ac.uk/id/document/1559144> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10163952/4/preview.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/4/preview.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "preview.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1559145> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://www.w3.org/2000/01/rdf-schema#label> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://eprints.org/relation/ismediumThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10163952/5/medium.jpg> .
<https://discovery.ucl.ac.uk/id/document/1559145> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10163952/5/medium.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/5/medium.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "medium.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1559146> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://www.w3.org/2000/01/rdf-schema#label> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://eprints.org/relation/issmallThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10163952/6/small.jpg> .
<https://discovery.ucl.ac.uk/id/document/1559146> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10163952/6/small.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/6/small.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "small.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1559147> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://www.w3.org/2000/01/rdf-schema#label> "Choroidal-scleral cell interplay and the regulation of scleral biomechanics (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/1521864> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10163952/7/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/document/1559147> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10163952/7/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/7/indexcodes.txt> <http://www.w3.org/2000/01/rdf-schema#label> "indexcodes.txt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10163952> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/10163952/> .
<https://discovery.ucl.ac.uk/id/eprint/10163952/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #10163952 \n\nChoroidal-scleral cell interplay and the regulation of scleral biomechanics\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/10163952/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/10163952/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10163952> .