eprintid: 10163651
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/16/36/51
datestamp: 2023-01-24 12:11:06
lastmod: 2023-01-24 12:11:06
status_changed: 2023-01-24 12:11:06
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Cullinane, Patrick W
creators_name: Sidle, Katie
creators_name: Bhatia, Kailash P
creators_name: Revesz, Tamas
creators_name: Warner, Thomas T
title: Globular glial tauopathy type II
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
divisions: F84
keywords: NEUROPATHOLOGY
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: The globular glial tauopathies (GGTs) are a rare group of neurodegenerative diseases with fewer than 90 autopsy-confirmed cases reported in the literature. Although there has been some uncertainty about whether GGT is entirely distinct from progressive supranuclear palsy, a recent study of tau filament structures supports the definition of GGT as a separate neuropathological entity. We present a sporadic case of GGT type II presenting with a progressive corticobasal-primary lateral sclerosis overlap syndrome in a 74-year-old woman. Neuropathological examination identified neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial inclusions. We also discuss the clinical features and molecular pathophysiology of GGT. Increased awareness of this condition could become more important as patients with GGT may be candidates for anti-tau therapies currently undergoing clinical evaluation in patients with other tauopathies.
date: 2022-11-21
date_type: published
publisher: BMJ Publishing Group
official_url: https://doi.org/10.1136/pn-2022-003549
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1992240
doi: 10.1136/pn-2022-003549
medium: Print-Electronic
pii: pn-2022-003549
lyricists_name: Bhatia, Kailash
lyricists_name: Revesz, Tamas
lyricists_name: Warner, Thomas
lyricists_id: KPBHA96
lyricists_id: TREVE26
lyricists_id: TTWAR25
actors_name: Warner, Thomas
actors_id: TTWAR25
actors_role: owner
funding_acknowledgements: [PWC is supported by funding from the Reta Lila Weston Trust for Medical Research]
full_text_status: public
publication: Practical Neurology
event_location: England
issn: 1474-7766
citation:        Cullinane, Patrick W;    Sidle, Katie;    Bhatia, Kailash P;    Revesz, Tamas;    Warner, Thomas T;      (2022)    Globular glial tauopathy type II.                   Practical Neurology        10.1136/pn-2022-003549 <https://doi.org/10.1136/pn-2022-003549>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10163651/1/Warner_GGTII_2_docx.pdf