TY  - INPR
UR  - https://doi.org/10.1136/pn-2022-003549
TI  - Globular glial tauopathy type II
KW  - NEUROPATHOLOGY
N2  - The globular glial tauopathies (GGTs) are a rare group of neurodegenerative diseases with fewer than 90 autopsy-confirmed cases reported in the literature. Although there has been some uncertainty about whether GGT is entirely distinct from progressive supranuclear palsy, a recent study of tau filament structures supports the definition of GGT as a separate neuropathological entity. We present a sporadic case of GGT type II presenting with a progressive corticobasal-primary lateral sclerosis overlap syndrome in a 74-year-old woman. Neuropathological examination identified neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial inclusions. We also discuss the clinical features and molecular pathophysiology of GGT. Increased awareness of this condition could become more important as patients with GGT may be candidates for anti-tau therapies currently undergoing clinical evaluation in patients with other tauopathies.
Y1  - 2022/11/21/
PB  - BMJ Publishing Group
A1  - Cullinane, Patrick W
A1  - Sidle, Katie
A1  - Bhatia, Kailash P
A1  - Revesz, Tamas
A1  - Warner, Thomas T
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SN  - 1474-7766
ID  - discovery10163651
AV  - public
JF  - Practical Neurology
ER  -