TY  - JOUR
VL  - 22
PB  - Springer Science and Business Media LLC
A1  - Da Silva, K
A1  - Guilly, S
A1  - Thirion, F
A1  - Le Chatelier, E
A1  - Pons, N
A1  - Roume, H
A1  - Quinquis, B
A1  - Ehrlich, SD
A1  - Bekkat, N
A1  - Mathiex-Fortunet, H
A1  - Sokol, H
A1  - Doré, J
Y1  - 2022/12/01/
IS  - 1
N2  - Background: Diosmectite, a natural colloidal clay, has been used worldwide for a number of approved indications, including the treatment of chronic functional diarrhea. Here, we used high-resolution whole metagenome shotgun sequencing to assess the impact of a 5 weeks administration of diosmectite (3 g/sachet, 3 sachets/day) on the fecal microbiota of 35 adults with functional chronic diarrhea. Results: Gut microbiota was not impacted by diosmectite administration. In particular, richness remained stable and no microbial species displayed a significant evolution. Segregating patients either by diosmectite response (non responder, early responder, late responder) or by nationality (Great-Britain or Netherlands) yielded the same results. Conclusion: We concluded that no microbiota-related physiological alterations are expected upon long-term treatment with diosmectite. Trial registration: Clinicaltrials.gov NCT03045926.
AV  - public
JF  - BMC Microbiology
N1  - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
ID  - discovery10163252
TI  - Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea
KW  - Chronic diarrhea
KW  -  Diosmectite
KW  -  Gut microbiota
KW  -  Long-term diosmectite use
KW  -  Loose stools
KW  -  Microbiota composition
KW  -  Shotgun metagenomics
KW  -  Smecta®
KW  -  Watery stools
KW  -  Adolescent
KW  -  Adult
KW  -  Bacteria
KW  -  Chronic Disease
KW  -  Diarrhea
KW  -  Feces
KW  -  Female
KW  -  Gastrointestinal Microbiome
KW  -  Humans
KW  -  Male
KW  -  Metagenome
KW  -  Middle Aged
KW  -  Silicates
KW  -  Young Adult
UR  - https://doi.org/10.1186/s12866-022-02464-7
ER  -