<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10162570> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/title> "Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson's disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/abstract> "Early identification of cognitive impairment in Parkinson’s disease (PD) has important clinical and research implications. The aim of our study was to investigate the role of plasma tau phosphorylated at amino acid 181 (p-tau181) and plasma neurofilament light chain (NfL) as biomarkers of cognition in PD. Baseline concentrations of plasma p-tau181 and NfL were measured in a cohort of 136 patients with PD and 63 healthy controls (HC). Forty-seven PD patients were followed up for up to 2 years. Cross-sectional and longitudinal associations between baseline plasma biomarkers and cognitive progression were investigated using linear regression and linear mixed effects models. At baseline, plasma p-tau181 concentration was significantly higher in PD subjects compared with HC (p = 0.026). In PD patients, higher plasma NfL was associated with lower MMSE score at baseline, after adjusting for age, sex and education (p = 0.027). Baseline plasma NfL also predicted MMSE decline over time in the PD group (p = 0.020). No significant association between plasma p-tau181 concentration and baseline or longitudinal cognitive performance was found. While the role of p-tau181 as a diagnostic biomarker for PD and its relationship with cognition need further elucidation, plasma NfL may serve as a feasible, non-invasive biomarker of cognitive progression in PD."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/date> "2022-11-12" . <https://discovery.ucl.ac.uk/id/document/1519989> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/volume> "8" . <https://discovery.ucl.ac.uk/id/org/ext-087b16d4eb8dd879f2b3db2c6f41bf76> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-087b16d4eb8dd879f2b3db2c6f41bf76> <http://xmlns.com/foaf/0.1/name> "NATURE PORTFOLIO"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-087b16d4eb8dd879f2b3db2c6f41bf76> . <https://discovery.ucl.ac.uk/id/publication/ext-23738057> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-23738057> <http://xmlns.com/foaf/0.1/name> "npj Parkinson's Disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-23738057> . <https://discovery.ucl.ac.uk/id/publication/ext-23738057> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:23738057> . <https://discovery.ucl.ac.uk/id/publication/ext-23738057> <http://purl.org/ontology/bibo/issn> "23738057" . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10162570> 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<http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-85b114b71bd3a9ea278bfdffc6bbd91b> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-85b114b71bd3a9ea278bfdffc6bbd91b> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-083a49fcf0cae820d0f4474b809351a3> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-083a49fcf0cae820d0f4474b809351a3> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cdcf578148fc08a4fac9bcf2d34835f0> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-cdcf578148fc08a4fac9bcf2d34835f0> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a6dd43518118e37d7a2ba4153884f997> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-a6dd43518118e37d7a2ba4153884f997> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6fbef873d8f15fe13de8103644caee09> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-6fbef873d8f15fe13de8103644caee09> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cfd8e5e0e1757087535160d4107cfea4> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-cfd8e5e0e1757087535160d4107cfea4> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-180cf3b4babffb1d498f2f84ea77dae8> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-180cf3b4babffb1d498f2f84ea77dae8> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d92be5afdc5affaa8acffdf7d31ebbb8> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d92be5afdc5affaa8acffdf7d31ebbb8> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5138d07fb796a20817992965709b2da4> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-5138d07fb796a20817992965709b2da4> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-357f998fb620fb72e70512886b81567e> . <https://discovery.ucl.ac.uk/id/eprint/10162570> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> . <https://discovery.ucl.ac.uk/id/eprint/10162570#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-357f998fb620fb72e70512886b81567e> . <https://discovery.ucl.ac.uk/id/person/ext-083a49fcf0cae820d0f4474b809351a3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-083a49fcf0cae820d0f4474b809351a3> <http://xmlns.com/foaf/0.1/givenName> "Amanda"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-083a49fcf0cae820d0f4474b809351a3> <http://xmlns.com/foaf/0.1/familyName> "Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-083a49fcf0cae820d0f4474b809351a3> <http://xmlns.com/foaf/0.1/name> "Amanda Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cdcf578148fc08a4fac9bcf2d34835f0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-cdcf578148fc08a4fac9bcf2d34835f0> <http://xmlns.com/foaf/0.1/givenName> "Dhaval"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cdcf578148fc08a4fac9bcf2d34835f0> <http://xmlns.com/foaf/0.1/familyName> "Trivedi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cdcf578148fc08a4fac9bcf2d34835f0> <http://xmlns.com/foaf/0.1/name> "Dhaval Trivedi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-180cf3b4babffb1d498f2f84ea77dae8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-180cf3b4babffb1d498f2f84ea77dae8> <http://xmlns.com/foaf/0.1/givenName> "Alexandra"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-180cf3b4babffb1d498f2f84ea77dae8> <http://xmlns.com/foaf/0.1/familyName> "Rizos"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-180cf3b4babffb1d498f2f84ea77dae8> <http://xmlns.com/foaf/0.1/name> "Alexandra Rizos"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5138d07fb796a20817992965709b2da4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5138d07fb796a20817992965709b2da4> <http://xmlns.com/foaf/0.1/givenName> "K Ray"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5138d07fb796a20817992965709b2da4> <http://xmlns.com/foaf/0.1/familyName> "Chaudhuri"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5138d07fb796a20817992965709b2da4> <http://xmlns.com/foaf/0.1/name> "K Ray Chaudhuri"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed3a3752a08de686781a4a73c1c85c86> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ed3a3752a08de686781a4a73c1c85c86> <http://xmlns.com/foaf/0.1/givenName> "Silvia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed3a3752a08de686781a4a73c1c85c86> <http://xmlns.com/foaf/0.1/familyName> "Rota"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed3a3752a08de686781a4a73c1c85c86> <http://xmlns.com/foaf/0.1/name> "Silvia Rota"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d14405a82d9fcf95ecf1dc6ed772359d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d14405a82d9fcf95ecf1dc6ed772359d> <http://xmlns.com/foaf/0.1/givenName> "Lucia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d14405a82d9fcf95ecf1dc6ed772359d> <http://xmlns.com/foaf/0.1/familyName> "Batzu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d14405a82d9fcf95ecf1dc6ed772359d> <http://xmlns.com/foaf/0.1/name> "Lucia Batzu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6fbef873d8f15fe13de8103644caee09> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6fbef873d8f15fe13de8103644caee09> <http://xmlns.com/foaf/0.1/givenName> "Chloe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6fbef873d8f15fe13de8103644caee09> <http://xmlns.com/foaf/0.1/familyName> "Farrell"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6fbef873d8f15fe13de8103644caee09> <http://xmlns.com/foaf/0.1/name> "Chloe Farrell"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a6dd43518118e37d7a2ba4153884f997> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a6dd43518118e37d7a2ba4153884f997> <http://xmlns.com/foaf/0.1/givenName> "Lucy L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a6dd43518118e37d7a2ba4153884f997> <http://xmlns.com/foaf/0.1/familyName> "Gibson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a6dd43518118e37d7a2ba4153884f997> <http://xmlns.com/foaf/0.1/name> "Lucy L Gibson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-85b114b71bd3a9ea278bfdffc6bbd91b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-85b114b71bd3a9ea278bfdffc6bbd91b> <http://xmlns.com/foaf/0.1/givenName> "Abdul"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-85b114b71bd3a9ea278bfdffc6bbd91b> <http://xmlns.com/foaf/0.1/familyName> "Hye"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-85b114b71bd3a9ea278bfdffc6bbd91b> <http://xmlns.com/foaf/0.1/name> "Abdul Hye"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d92be5afdc5affaa8acffdf7d31ebbb8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d92be5afdc5affaa8acffdf7d31ebbb8> <http://xmlns.com/foaf/0.1/givenName> "Henrik"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d92be5afdc5affaa8acffdf7d31ebbb8> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d92be5afdc5affaa8acffdf7d31ebbb8> <http://xmlns.com/foaf/0.1/name> "Henrik 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