eprintid: 10162404
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/16/24/04
datestamp: 2023-01-04 10:02:22
lastmod: 2023-01-04 10:02:22
status_changed: 2023-01-04 10:02:22
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Hernández-Bejarano, M
creators_name: Gestri, G
creators_name: Monfries, C
creators_name: Tucker, L
creators_name: Dragomir, EI
creators_name: Bianco, IH
creators_name: Bovolenta, P
creators_name: Wilson, SW
creators_name: Cavodeassi, F
title: Foxd1-dependent induction of a temporal retinal character is required for visual function
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
divisions: G02
keywords: Foxd1, Rx3, Retinal patterning, Fovea,
Area temporalis, OKR, OMR, Zebrafish
note: © 2022. Published by The Company of Biologists Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
abstract: Appropriate patterning of the retina during embryonic development is assumed to underlie the establishment of spatially localised specialisations that mediate the perception of specific visual features. For example, in zebrafish, an area involved in high acuity vision (HAA) is thought to be present in the ventro-temporal retina. Here, we show that the interplay of the transcription factor Rx3 with Fibroblast Growth Factor and Hedgehog signals initiates and restricts foxd1 expression to the prospective temporal retina, initiating naso-temporal regionalisation of the retina. Abrogation of Foxd1 results in the loss of temporal and expansion of nasal retinal character, and consequent absence of the HAA. These structural defects correlate with severe visual defects, as assessed in optokinetic and optomotor response assays. In contrast, optokinetic responses are unaffected in the opposite condition, in which nasal retinal character is lost at the expense of expanded temporal character. Our study indicates that the establishment of temporal retinal character during early retinal development is required for the specification of the HAA, and suggests a prominent role of the temporal retina in controlling specific visual functions.
date: 2022-12-15
date_type: published
publisher: The Company of Biologists
official_url: https://doi.org/10.1242/dev.200938
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1997217
doi: 10.1242/dev.200938
medium: Print-Electronic
pii: 285946
lyricists_name: Wilson, Stephen
lyricists_name: Gestri, Gaia
lyricists_name: Bianco, Isaac
lyricists_id: SWILS65
lyricists_id: GGEST91
lyricists_id: IHBIA26
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: 213928/Z/18/Z [Wellcome Trust]; MR/L003775/1 [Medical Research Council]
full_text_status: public
publication: Development
volume: 149
number: 24
article_number: dev200938
event_location: England
citation:        Hernández-Bejarano, M;    Gestri, G;    Monfries, C;    Tucker, L;    Dragomir, EI;    Bianco, IH;    Bovolenta, P;         ... Cavodeassi, F; + view all <#>        Hernández-Bejarano, M;  Gestri, G;  Monfries, C;  Tucker, L;  Dragomir, EI;  Bianco, IH;  Bovolenta, P;  Wilson, SW;  Cavodeassi, F;   - view fewer <#>    (2022)    Foxd1-dependent induction of a temporal retinal character is required for visual function.                   Development , 149  (24)    , Article dev200938.  10.1242/dev.200938 <https://doi.org/10.1242/dev.200938>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10162404/1/DownloadCombinedArticleAndSupplmentPdf.pdf