eprintid: 10161862 rev_number: 12 eprint_status: archive userid: 699 dir: disk0/10/16/18/62 datestamp: 2022-12-16 10:53:37 lastmod: 2023-05-10 06:10:08 status_changed: 2022-12-16 10:56:09 type: article metadata_visibility: show sword_depositor: 699 creators_name: Kupferschmidt, David A creators_name: Cummings, Kirstie A creators_name: Joffe, Max E creators_name: MacAskill, Andrew creators_name: Malik, Ruchi creators_name: Sanchez-Bellot, Candela creators_name: Tejeda, Hugo A creators_name: Castillo, Hector Yarur title: Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: G02 keywords: BASOLATERAL AMYGDALA, cognition, CORTICAL INTERNEURONS, EXCITATORY SYNAPSES, FAST-SPIKING INTERNEURON, FEEDFORWARD INHIBITION, GABAERGIC INTERNEURONS, inhibitory neurons, Life Sciences & Biomedicine, LONG-TERM POTENTIATION, microcircuits, MOUSE MODEL, Neurosciences, Neurosciences & Neurology, PARVALBUMIN INTERNEURONS, plasticity, prefrontal cortex, Science & Technology, TRANSCRIPTOMIC CELL-TYPES note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural communication to support adaptive cognition and contextually tuned behavior. Accordingly, perturbations of PFC inhibitory microcircuits are thought to underlie dysregulated cognition and behavior in numerous psychiatric diseases and relevant animal models. This review, based on a Mini-Symposium presented at the 2022 Society for Neuroscience Meeting, highlights recent studies providing novel insights into: (1) discrete medial PFC (mPFC) interneuron populations in the mouse brain; (2) mPFC interneuron connections with, and regulation of, long-range mPFC afferents; and (3) circuit-specific plasticity of mPFC interneurons. The contributions of such populations, pathways, and plasticity to rodent cognition are discussed in the context of stress, reward, motivational conflict, and genetic mutations relevant to psychiatric disease. date: 2022-11-09 date_type: published publisher: Society for Neuroscience official_url: https://doi.org/10.1523/JNEUROSCI.1136-22.2022 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1990229 doi: 10.1523/JNEUROSCI.1136-22.2022 medium: Print pii: 42/45/8468 lyricists_name: Macaskill, Andrew lyricists_id: AFMAC80 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner funding_acknowledgements: ZIANS003168 [National Institute of Neurological Disorders and Stroke Intramural Research Program]; R00 MH122228 [National Institute of Mental Health]; R01 MH062646 [National Institute of Mental Health]; K99/R00 AA027806 [National Institute on Alcohol Abuse and Alcoholism]; R37 NS031373 [National Institute of Neurological Disorders and Stroke]; 109360/Z/15/Z [Wellcome Trust Sir Henry Dale Fellowship]; [Brain and Behavior Research Foundation National Alliance for Research on Schizophrenia and Depression Young Investigator Grant]; TSCRP 127574A [Department of Defense]; 206074/Z/17/Z [Wellcome Trust]; ZIAMH002970 [National Institute of Mental Health Intramural Research Program]; [NIH Center for Compulsive Behaviors Fellowship] full_text_status: public publication: The Journal of Neuroscience volume: 42 number: 45 pagerange: 8468-8476 pages: 9 event_location: United States citation: Kupferschmidt, David A; Cummings, Kirstie A; Joffe, Max E; MacAskill, Andrew; Malik, Ruchi; Sanchez-Bellot, Candela; Tejeda, Hugo A; Kupferschmidt, David A; Cummings, Kirstie A; Joffe, Max E; MacAskill, Andrew; Malik, Ruchi; Sanchez-Bellot, Candela; Tejeda, Hugo A; Castillo, Hector Yarur; - view fewer <#> (2022) Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models. The Journal of Neuroscience , 42 (45) pp. 8468-8476. 10.1523/JNEUROSCI.1136-22.2022 <https://doi.org/10.1523/JNEUROSCI.1136-22.2022>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10161862/1/8468.full.pdf