eprintid: 10161862
rev_number: 12
eprint_status: archive
userid: 699
dir: disk0/10/16/18/62
datestamp: 2022-12-16 10:53:37
lastmod: 2023-05-10 06:10:08
status_changed: 2022-12-16 10:56:09
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Kupferschmidt, David A
creators_name: Cummings, Kirstie A
creators_name: Joffe, Max E
creators_name: MacAskill, Andrew
creators_name: Malik, Ruchi
creators_name: Sanchez-Bellot, Candela
creators_name: Tejeda, Hugo A
creators_name: Castillo, Hector Yarur
title: Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G02
keywords: BASOLATERAL AMYGDALA, cognition, CORTICAL INTERNEURONS, EXCITATORY SYNAPSES, FAST-SPIKING INTERNEURON, FEEDFORWARD INHIBITION, GABAERGIC INTERNEURONS, inhibitory neurons, Life Sciences & Biomedicine, LONG-TERM POTENTIATION, microcircuits, MOUSE MODEL, Neurosciences, Neurosciences & Neurology, PARVALBUMIN INTERNEURONS, plasticity, prefrontal cortex, Science & Technology, TRANSCRIPTOMIC CELL-TYPES
note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural communication to support adaptive cognition and contextually tuned behavior. Accordingly, perturbations of PFC inhibitory microcircuits are thought to underlie dysregulated cognition and behavior in numerous psychiatric diseases and relevant animal models. This review, based on a Mini-Symposium presented at the 2022 Society for Neuroscience Meeting, highlights recent studies providing novel insights into: (1) discrete medial PFC (mPFC) interneuron populations in the mouse brain; (2) mPFC interneuron connections with, and regulation of, long-range mPFC afferents; and (3) circuit-specific plasticity of mPFC interneurons. The contributions of such populations, pathways, and plasticity to rodent cognition are discussed in the context of stress, reward, motivational conflict, and genetic mutations relevant to psychiatric disease.
date: 2022-11-09
date_type: published
publisher: Society for Neuroscience
official_url: https://doi.org/10.1523/JNEUROSCI.1136-22.2022
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1990229
doi: 10.1523/JNEUROSCI.1136-22.2022
medium: Print
pii: 42/45/8468
lyricists_name: Macaskill, Andrew
lyricists_id: AFMAC80
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: ZIANS003168 [National Institute of Neurological Disorders and Stroke Intramural Research Program]; R00 MH122228 [National Institute of Mental Health]; R01 MH062646 [National Institute of Mental Health]; K99/R00 AA027806 [National Institute on Alcohol Abuse and Alcoholism]; R37 NS031373 [National Institute of Neurological Disorders and Stroke]; 109360/Z/15/Z [Wellcome Trust Sir Henry Dale Fellowship]; [Brain and Behavior Research Foundation National Alliance for Research on Schizophrenia and Depression Young Investigator Grant]; TSCRP 127574A [Department of Defense]; 206074/Z/17/Z [Wellcome Trust]; ZIAMH002970 [National Institute of Mental Health Intramural Research Program]; [NIH Center for Compulsive Behaviors Fellowship]
full_text_status: public
publication: The Journal of Neuroscience
volume: 42
number: 45
pagerange: 8468-8476
pages: 9
event_location: United States
citation:        Kupferschmidt, David A;    Cummings, Kirstie A;    Joffe, Max E;    MacAskill, Andrew;    Malik, Ruchi;    Sanchez-Bellot, Candela;    Tejeda, Hugo A;           Kupferschmidt, David A;  Cummings, Kirstie A;  Joffe, Max E;  MacAskill, Andrew;  Malik, Ruchi;  Sanchez-Bellot, Candela;  Tejeda, Hugo A;  Castillo, Hector Yarur;   - view fewer <#>    (2022)    Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.                   The Journal of Neuroscience , 42  (45)   pp. 8468-8476.    10.1523/JNEUROSCI.1136-22.2022 <https://doi.org/10.1523/JNEUROSCI.1136-22.2022>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10161862/1/8468.full.pdf