TY  - JOUR
N1  - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions.
ID  - discovery10161862
UR  - https://doi.org/10.1523/JNEUROSCI.1136-22.2022
PB  - Society for Neuroscience
JF  - The Journal of Neuroscience
SP  - 8468
N2  - Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural communication to support adaptive cognition and contextually tuned behavior. Accordingly, perturbations of PFC inhibitory microcircuits are thought to underlie dysregulated cognition and behavior in numerous psychiatric diseases and relevant animal models. This review, based on a Mini-Symposium presented at the 2022 Society for Neuroscience Meeting, highlights recent studies providing novel insights into: (1) discrete medial PFC (mPFC) interneuron populations in the mouse brain; (2) mPFC interneuron connections with, and regulation of, long-range mPFC afferents; and (3) circuit-specific plasticity of mPFC interneurons. The contributions of such populations, pathways, and plasticity to rodent cognition are discussed in the context of stress, reward, motivational conflict, and genetic mutations relevant to psychiatric disease.
AV  - public
TI  - Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models
Y1  - 2022/11/09/
VL  - 42
EP  - 8476
A1  - Kupferschmidt, David A
A1  - Cummings, Kirstie A
A1  - Joffe, Max E
A1  - MacAskill, Andrew
A1  - Malik, Ruchi
A1  - Sanchez-Bellot, Candela
A1  - Tejeda, Hugo A
A1  - Castillo, Hector Yarur
KW  - BASOLATERAL AMYGDALA
KW  -  cognition
KW  -  CORTICAL INTERNEURONS
KW  -  EXCITATORY SYNAPSES
KW  -  FAST-SPIKING INTERNEURON
KW  -  FEEDFORWARD INHIBITION
KW  -  GABAERGIC INTERNEURONS
KW  -  inhibitory neurons
KW  -  Life Sciences & Biomedicine
KW  -  LONG-TERM POTENTIATION
KW  -  microcircuits
KW  -  MOUSE MODEL
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  PARVALBUMIN INTERNEURONS
KW  -  plasticity
KW  -  prefrontal cortex
KW  -  Science & Technology
KW  -  TRANSCRIPTOMIC CELL-TYPES
IS  - 45
ER  -