TY - JOUR N1 - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions. ID - discovery10161862 UR - https://doi.org/10.1523/JNEUROSCI.1136-22.2022 PB - Society for Neuroscience JF - The Journal of Neuroscience SP - 8468 N2 - Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal neuron firing, coordinate neural ensemble interactions, and gate local and long-range neural communication to support adaptive cognition and contextually tuned behavior. Accordingly, perturbations of PFC inhibitory microcircuits are thought to underlie dysregulated cognition and behavior in numerous psychiatric diseases and relevant animal models. This review, based on a Mini-Symposium presented at the 2022 Society for Neuroscience Meeting, highlights recent studies providing novel insights into: (1) discrete medial PFC (mPFC) interneuron populations in the mouse brain; (2) mPFC interneuron connections with, and regulation of, long-range mPFC afferents; and (3) circuit-specific plasticity of mPFC interneurons. The contributions of such populations, pathways, and plasticity to rodent cognition are discussed in the context of stress, reward, motivational conflict, and genetic mutations relevant to psychiatric disease. AV - public TI - Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models Y1 - 2022/11/09/ VL - 42 EP - 8476 A1 - Kupferschmidt, David A A1 - Cummings, Kirstie A A1 - Joffe, Max E A1 - MacAskill, Andrew A1 - Malik, Ruchi A1 - Sanchez-Bellot, Candela A1 - Tejeda, Hugo A A1 - Castillo, Hector Yarur KW - BASOLATERAL AMYGDALA KW - cognition KW - CORTICAL INTERNEURONS KW - EXCITATORY SYNAPSES KW - FAST-SPIKING INTERNEURON KW - FEEDFORWARD INHIBITION KW - GABAERGIC INTERNEURONS KW - inhibitory neurons KW - Life Sciences & Biomedicine KW - LONG-TERM POTENTIATION KW - microcircuits KW - MOUSE MODEL KW - Neurosciences KW - Neurosciences & Neurology KW - PARVALBUMIN INTERNEURONS KW - plasticity KW - prefrontal cortex KW - Science & Technology KW - TRANSCRIPTOMIC CELL-TYPES IS - 45 ER -