TY  - INPR
UR  - https://doi.org/10.1016/j.lanepe.2022.100554
A1  - Pinto Pereira, Snehal M
A1  - Shafran, Roz
A1  - Nugawela, Manjula D
A1  - Panagi, Laura
A1  - Hargreaves, Dougal
A1  - Ladhani, Shamez N
A1  - Bennett, Sophie D
A1  - Chalder, Trudie
A1  - Dalrymple, Emma
A1  - Ford, Tamsin
A1  - Heyman, Isobel
A1  - McOwat, Kelsey
A1  - Rojas, Natalia K
A1  - Sharma, Kishan
A1  - Simmons, Ruth
A1  - White, Simon R
A1  - Stephenson, Terence
N2  - BACKGROUND: Despite high numbers of children and young people (CYP) having acute COVID, there has been no prospective follow-up of CYP to establish the pattern of health and well-being over a year following infection. METHODS: A non-hospitalised, national sample of 5086 (2909 SARS-COV-2 Positive; 2177 SARS-COV-2 Negative at baseline) CYP aged 11-17 completed questionnaires 6- and 12-months after PCR-tests between October 2020 and March 2021 confirming SARS-CoV-2 infection (excluding CYP with subsequent (re)infections). SARS-COV-2 Positive CYP was compared to age, sex and geographically-matched test-negative CYP. FINDINGS: Ten of 21 symptoms had a prevalence less than 10% at baseline, 6- and 12-months post-test in both test-positives and test-negatives. Of the other 11 symptoms, in test-positives who had these at baseline, the prevalence of all symptoms declined greatly by 12-months. For CYP first describing one of these at 6-months, there was a decline in prevalence by 12-months. The overall prevalence of 9 of 11 symptoms declined by 12-months. As many CYP first described shortness of breath and tiredness at either 6- or 12-months, the overall prevalence of these two symptoms in test-positives appeared to increase by 6-months and increase further by 12-months. However, within-individual examination demonstrated that the prevalence of shortness of breath and tiredness actually declined in those first describing these two symptoms at either baseline or 6-months. This pattern was also evident for these two symptoms in test-negatives. Similar patterns were observed for validated measures of poor quality of life, emotional and behavioural difficulties, poor well-being and fatigue. Moreover, broadly similar patterns and results were noted for the sub-sample (N = 1808) that had data at baseline, 3-, 6- and 12-months post-test. INTERPRETATION: In CYP, the prevalence of adverse symptoms reported at the time of a positive PCR-test declined over 12-months. Some test-positives and test-negatives reported adverse symptoms for the first time at six- and 12-months post-test, particularly tiredness, shortness of breath, poor quality of life, poor well-being and fatigue suggesting they are likely to be caused by multiple factors. FUNDING: NIHR/UKRI (ref: COVLT0022).
AV  - public
JF  - The Lancet Regional Health - Europe
KW  - CYP
KW  -  Children and young people
KW  -  Children and young people
KW  -  IQR
KW  -  Interquartile range
KW  -  Long COVID
KW  -  Longitudinal
KW  -  Symptoms
KW  -  UKHSA
KW  -  United Kingdom Health Security Agency
KW  -  Well-being
ID  - discovery10161811
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
PB  - Elsevier BV
TI  - Natural course of health and well-being in non-hospitalised children and young people after testing for SARS-CoV-2: A prospective follow-up study over 12 months
Y1  - 2022/12/05/
ER  -