TY  - JOUR
AV  - public
EP  - 1075
IS  - 11
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Gastroenterology & Hepatology
KW  -  Apolipoprotein E
KW  -  Polymorphism
KW  -  Liver cirrhosis
KW  -  Hepatitis C virus
KW  -  Hepatocellular carcinoma
KW  -  Liver transplantation
KW  -  DISEASE
KW  -  FIBROSIS
KW  -  ASSOCIATION
KW  -  PROGRESSION
KW  -  PROTEIN
KW  -  ALLELE
KW  -  APOE4
A1  - Nascimento, Jose Carlos Rodrigues
A1  - Pereira, Lianna C
A1  - Rego, Juliana Magalhaes C
A1  - Dias, Ronaldo P
A1  - Silva, Paulo Goberlanio B
A1  - Sobrinho, Silvio Alencar C
A1  - Coelho, Gustavo R
A1  - Brasil, Ivelise Regina C
A1  - Oliveira-Filho, Edmilson F
A1  - Owen, James S
A1  - Toniutto, Pierluigi
A1  - Oria, Reinaldo B
SP  - 1064
PB  - BAISHIDENG PUBLISHING GROUP INC
UR  - http://dx.doi.org/10.3748/wjg.v27.i11.1064
TI  - Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis
ID  - discovery10161492
VL  - 27
N2  - BACKGROUND: Hepatitis C virus (HCV) infection is responsible for a chronic liver inflammation, which may cause end-stage liver disease and hepatocellular carcinoma. Apolipoprotein E (protein: ApoE, gene: APOE), a key player in cholesterol metabolism, is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage. AIM: To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation (OLT). METHODS: This was a cohort study in which 179 patients, both genders and aged 34-70 years, were included before or after (up to 10 years follow-up) OLT. Liver injury severity was assessed using different criteria, including METAVIR and models for end-stage liver disease. APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction. RESULTS: The APOE3 allele was the most common (67.3%). In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant, the degree of severe inflammation (A3F4, 0.0%) was significantly less frequent than in patients with minimal and moderate degree of inflammation (? A2F4, 16.2%) P = 0.048, in patients carrying the APOE4 allele when compared to non-APOE4. In addition, a significant difference was also found (? A2F4, 64.4% vs A3F4, 0.0%; P = 0.043) and (A1F4, 57.4% vs A3F4, 0.0%; P = 0.024) in APOE4 patients when compared to APOE3 carriers. The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis (F2) (P = 0.006). CONCLUSION: Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.
Y1  - 2021/03/21/
JF  - World Journal of Gastroenterology
N1  - Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Nascimento JCR, Pereira LC, Rêgo JMC, Dias RP, Silva PGB, Sobrinho SAC, Coelho GR, Brasil IRC, Oliveira-Filho EF, Owen JS, Toniutto P, Oriá RB. Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis. World J Gastroenterol 2021; 27(11): 1064-1075 [PMID: 33776373 DOI: 10.3748/wjg.v27.i11.1064]
ER  -