<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10161492> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/title> "Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Hepatitis C virus (HCV) infection is responsible for a chronic liver inflammation, which may cause end-stage liver disease and hepatocellular carcinoma. Apolipoprotein E (protein: ApoE, gene: APOE), a key player in cholesterol metabolism, is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage. AIM: To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation (OLT). METHODS: This was a cohort study in which 179 patients, both genders and aged 34-70 years, were included before or after (up to 10 years follow-up) OLT. Liver injury severity was assessed using different criteria, including METAVIR and models for end-stage liver disease. APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction. RESULTS: The APOE3 allele was the most common (67.3%). In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant, the degree of severe inflammation (A3F4, 0.0%) was significantly less frequent than in patients with minimal and moderate degree of inflammation (≤ A2F4, 16.2%) P = 0.048, in patients carrying the APOE4 allele when compared to non-APOE4. In addition, a significant difference was also found (≤ A2F4, 64.4% vs A3F4, 0.0%; P = 0.043) and (A1F4, 57.4% vs A3F4, 0.0%; P = 0.024) in APOE4 patients when compared to APOE3 carriers. The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis (F2) (P = 0.006). CONCLUSION: Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/date> "2021-03-21" . <https://discovery.ucl.ac.uk/id/document/1518669> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/volume> "27" . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/issue> "11" . <https://discovery.ucl.ac.uk/id/org/ext-6a75bbf8012db9fa44dc0368a4d0020b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-6a75bbf8012db9fa44dc0368a4d0020b> <http://xmlns.com/foaf/0.1/name> "BAISHIDENG PUBLISHING GROUP INC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-6a75bbf8012db9fa44dc0368a4d0020b> . <https://discovery.ucl.ac.uk/id/publication/ext-b18b24cc5e51e9c76478d926490d0bc0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-b18b24cc5e51e9c76478d926490d0bc0> <http://xmlns.com/foaf/0.1/name> "World Journal of Gastroenterology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-b18b24cc5e51e9c76478d926490d0bc0> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a4e677e33944c6c75699ab954d074e86> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-a4e677e33944c6c75699ab954d074e86> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ceed729747842ee4ecd59c209a954c50> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-ceed729747842ee4ecd59c209a954c50> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f881aeedb216ce36ef134cffdc48275d> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-f881aeedb216ce36ef134cffdc48275d> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9dad11a7942265c19d7feafba01464b8> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-9dad11a7942265c19d7feafba01464b8> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f55c2c6927c31fccce552c3ccc1a1e14> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-f55c2c6927c31fccce552c3ccc1a1e14> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-53dbee7ef9868eb500b11531115b54a1> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-53dbee7ef9868eb500b11531115b54a1> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-be939d18f1d4f8efcb7184cc43fb7874> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-be939d18f1d4f8efcb7184cc43fb7874> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f7e9e43e7bcde7032d88f17e0a686bcd> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-f7e9e43e7bcde7032d88f17e0a686bcd> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b82bb3e482126f47f6d75d571fbae275> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-b82bb3e482126f47f6d75d571fbae275> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-40c4449adc1b646c04ed0c6c749f6917> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-40c4449adc1b646c04ed0c6c749f6917> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6bc99ebfe9429a0f744a7370ed8d3db5> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-6bc99ebfe9429a0f744a7370ed8d3db5> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8dc664f396612c51b80c333d243da278> . <https://discovery.ucl.ac.uk/id/eprint/10161492> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> . <https://discovery.ucl.ac.uk/id/eprint/10161492#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-8dc664f396612c51b80c333d243da278> . <https://discovery.ucl.ac.uk/id/person/ext-be939d18f1d4f8efcb7184cc43fb7874> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-be939d18f1d4f8efcb7184cc43fb7874> <http://xmlns.com/foaf/0.1/givenName> "Gustavo R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-be939d18f1d4f8efcb7184cc43fb7874> <http://xmlns.com/foaf/0.1/familyName> "Coelho"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-be939d18f1d4f8efcb7184cc43fb7874> <http://xmlns.com/foaf/0.1/name> "Gustavo R Coelho"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f55c2c6927c31fccce552c3ccc1a1e14> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f55c2c6927c31fccce552c3ccc1a1e14> <http://xmlns.com/foaf/0.1/givenName> "Paulo Goberlanio B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f55c2c6927c31fccce552c3ccc1a1e14> <http://xmlns.com/foaf/0.1/familyName> "Silva"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f55c2c6927c31fccce552c3ccc1a1e14> <http://xmlns.com/foaf/0.1/name> "Paulo Goberlanio B Silva"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8dc664f396612c51b80c333d243da278> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8dc664f396612c51b80c333d243da278> <http://xmlns.com/foaf/0.1/givenName> "Reinaldo B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8dc664f396612c51b80c333d243da278> <http://xmlns.com/foaf/0.1/familyName> "Oria"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8dc664f396612c51b80c333d243da278> <http://xmlns.com/foaf/0.1/name> "Reinaldo B Oria"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a4e677e33944c6c75699ab954d074e86> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a4e677e33944c6c75699ab954d074e86> <http://xmlns.com/foaf/0.1/givenName> "Jose Carlos Rodrigues"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a4e677e33944c6c75699ab954d074e86> <http://xmlns.com/foaf/0.1/familyName> "Nascimento"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a4e677e33944c6c75699ab954d074e86> <http://xmlns.com/foaf/0.1/name> "Jose Carlos Rodrigues Nascimento"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ceed729747842ee4ecd59c209a954c50> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ceed729747842ee4ecd59c209a954c50> <http://xmlns.com/foaf/0.1/givenName> "Lianna C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ceed729747842ee4ecd59c209a954c50> <http://xmlns.com/foaf/0.1/familyName> "Pereira"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ceed729747842ee4ecd59c209a954c50> <http://xmlns.com/foaf/0.1/name> "Lianna C Pereira"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-40c4449adc1b646c04ed0c6c749f6917> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-40c4449adc1b646c04ed0c6c749f6917> <http://xmlns.com/foaf/0.1/givenName> "James S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-40c4449adc1b646c04ed0c6c749f6917> <http://xmlns.com/foaf/0.1/familyName> "Owen"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-40c4449adc1b646c04ed0c6c749f6917> <http://xmlns.com/foaf/0.1/name> "James S Owen"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b82bb3e482126f47f6d75d571fbae275> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b82bb3e482126f47f6d75d571fbae275> <http://xmlns.com/foaf/0.1/givenName> "Edmilson F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b82bb3e482126f47f6d75d571fbae275> <http://xmlns.com/foaf/0.1/familyName> "Oliveira-Filho"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b82bb3e482126f47f6d75d571fbae275> <http://xmlns.com/foaf/0.1/name> "Edmilson F Oliveira-Filho"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f881aeedb216ce36ef134cffdc48275d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f881aeedb216ce36ef134cffdc48275d> <http://xmlns.com/foaf/0.1/givenName> "Juliana Magalhaes C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f881aeedb216ce36ef134cffdc48275d> <http://xmlns.com/foaf/0.1/familyName> "Rego"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f881aeedb216ce36ef134cffdc48275d> <http://xmlns.com/foaf/0.1/name> "Juliana Magalhaes C Rego"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-53dbee7ef9868eb500b11531115b54a1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-53dbee7ef9868eb500b11531115b54a1> <http://xmlns.com/foaf/0.1/givenName> "Silvio Alencar C"^^<http://www.w3.org/2001/XMLSchema#string> . 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