<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/title> "Efficacy of Omaveloxolone in Friedreich's Ataxia: Delayed-Start Analysis of the MOXIe Extension"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: MOXIe was a two-part study evaluating the safety and efficacy of omaveloxolone in patients with Friedreich's ataxia, a rare, progressive neurological disease with no proven therapy. MOXIe part 2, a randomized double-blind placebo-controlled trial, showed omaveloxolone significantly improved modified Friedreich's Ataxia Rating Scale (mFARS) scores relative to placebo. Patients who completed part 1 or 2 were eligible to receive omaveloxolone in an open-label extension study. OBJECTIVE: The delayed-start study compared mFARS scores at the end of MOXIe part 2 with those at 72 weeks in the open-label extension period (up to 144 weeks) for patients initially randomized to omaveloxolone versus those initially randomized to placebo. METHODS: We performed a noninferiority test to compare the difference between treatment groups (placebo to omaveloxolone versus omaveloxolone to omaveloxolone) using a single mixed model repeated measures (MMRM) model. In addition, slopes of the change in mFARS scores were compared between both groups in the open-label extension. RESULTS: The noninferiority testing demonstrated that the difference in mFARS between omaveloxolone and placebo observed at the end of placebo-controlled MOXIe part 2 (-2.17 ± 1.09 points) was preserved after 72 weeks in the extension (-2.91 ± 1.44 points). In addition, patients previously randomized to omaveloxolone in MOXIe part 2 continued to show no worsening in mFARS relative to their extension baseline through 144 weeks. CONCLUSIONS: These results support the positive results of MOXIe part 2 and indicate a persistent benefit of omaveloxolone treatment on disease course in Friedreich's ataxia. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/date> "2022-11-29" .
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<https://discovery.ucl.ac.uk/id/publication/ext-08853185> <http://xmlns.com/foaf/0.1/name> "Movement Disorders"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d9b13c89bb4ddc99a333d0d487e267cf> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-d9b13c89bb4ddc99a333d0d487e267cf> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-43dba96b5bcdccd003617f17b15b8567> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-43dba96b5bcdccd003617f17b15b8567> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-34a7d22e2386abbc076858472cb56167> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d76a8e8acada9e7a81486f5c9c4d321a> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-d76a8e8acada9e7a81486f5c9c4d321a> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-deb76919633a1175d2c529bfed378fc5> .
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<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2de86ed7475d3a96c5f4a252284b17e5> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-2de86ed7475d3a96c5f4a252284b17e5> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5b01f404525754bc85115ce33097700f> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-5b01f404525754bc85115ce33097700f> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-035afbe0967d37d4485f8d427d520300> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-035afbe0967d37d4485f8d427d520300> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-be582908a2e7865ed8b37fae354dd2d5> .
<https://discovery.ucl.ac.uk/id/eprint/10161377> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10161377#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10161377#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-be582908a2e7865ed8b37fae354dd2d5> .
<https://discovery.ucl.ac.uk/id/person/ext-2886822e359756fdeda9af654065a7c7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2886822e359756fdeda9af654065a7c7> <http://xmlns.com/foaf/0.1/givenName> "J Chad"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2886822e359756fdeda9af654065a7c7> <http://xmlns.com/foaf/0.1/familyName> "Hoyle"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2886822e359756fdeda9af654065a7c7> <http://xmlns.com/foaf/0.1/name> "J Chad Hoyle"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dec6bbb62a3e9e2a61c309f783bf6e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dec6bbb62a3e9e2a61c309f783bf6e> <http://xmlns.com/foaf/0.1/givenName> "Melanie P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dec6bbb62a3e9e2a61c309f783bf6e> <http://xmlns.com/foaf/0.1/familyName> "Chin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2dec6bbb62a3e9e2a61c309f783bf6e> <http://xmlns.com/foaf/0.1/name> "Melanie P Chin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be582908a2e7865ed8b37fae354dd2d5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-be582908a2e7865ed8b37fae354dd2d5> <http://xmlns.com/foaf/0.1/givenName> "Colin J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be582908a2e7865ed8b37fae354dd2d5> <http://xmlns.com/foaf/0.1/familyName> "Meyer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be582908a2e7865ed8b37fae354dd2d5> <http://xmlns.com/foaf/0.1/name> "Colin J Meyer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-deb76919633a1175d2c529bfed378fc5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-deb76919633a1175d2c529bfed378fc5> <http://xmlns.com/foaf/0.1/givenName> "Susan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-deb76919633a1175d2c529bfed378fc5> <http://xmlns.com/foaf/0.1/familyName> "Perlman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-deb76919633a1175d2c529bfed378fc5> <http://xmlns.com/foaf/0.1/name> "Susan Perlman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a8ba6b2d56f54ba77c274b58bae7d3f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8a8ba6b2d56f54ba77c274b58bae7d3f> <http://xmlns.com/foaf/0.1/givenName> "Martin B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a8ba6b2d56f54ba77c274b58bae7d3f> <http://xmlns.com/foaf/0.1/familyName> "Delatycki"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a8ba6b2d56f54ba77c274b58bae7d3f> <http://xmlns.com/foaf/0.1/name> "Martin B Delatycki"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0775a2b7c54a633d83c3887bb3bbb6c4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0775a2b7c54a633d83c3887bb3bbb6c4> <http://xmlns.com/foaf/0.1/givenName> "David R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0775a2b7c54a633d83c3887bb3bbb6c4> <http://xmlns.com/foaf/0.1/familyName> "Lynch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0775a2b7c54a633d83c3887bb3bbb6c4> <http://xmlns.com/foaf/0.1/name> "David R Lynch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43dba96b5bcdccd003617f17b15b8567> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-43dba96b5bcdccd003617f17b15b8567> <http://xmlns.com/foaf/0.1/givenName> "Katherine D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43dba96b5bcdccd003617f17b15b8567> <http://xmlns.com/foaf/0.1/familyName> "Mathews"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43dba96b5bcdccd003617f17b15b8567> <http://xmlns.com/foaf/0.1/name> "Katherine D Mathews"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68fec6791ee0277a224bfea987c2a872> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-68fec6791ee0277a224bfea987c2a872> <http://xmlns.com/foaf/0.1/givenName> "Angie"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68fec6791ee0277a224bfea987c2a872> <http://xmlns.com/foaf/0.1/familyName> "Goldsberry"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68fec6791ee0277a224bfea987c2a872> <http://xmlns.com/foaf/0.1/name> "Angie Goldsberry"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b01f404525754bc85115ce33097700f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5b01f404525754bc85115ce33097700f> <http://xmlns.com/foaf/0.1/givenName> "George"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b01f404525754bc85115ce33097700f> <http://xmlns.com/foaf/0.1/familyName> "Wilmot"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b01f404525754bc85115ce33097700f> <http://xmlns.com/foaf/0.1/name> "George Wilmot"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be51f8f5b5331ce7342d28717b994f6e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-be51f8f5b5331ce7342d28717b994f6e> <http://xmlns.com/foaf/0.1/givenName> "Paola"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be51f8f5b5331ce7342d28717b994f6e> <http://xmlns.com/foaf/0.1/familyName> "Giunti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be51f8f5b5331ce7342d28717b994f6e> <http://xmlns.com/foaf/0.1/name> "Paola Giunti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-035afbe0967d37d4485f8d427d520300> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-035afbe0967d37d4485f8d427d520300> <http://xmlns.com/foaf/0.1/givenName> "Theresa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-035afbe0967d37d4485f8d427d520300> <http://xmlns.com/foaf/0.1/familyName> "Zesiewicz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-035afbe0967d37d4485f8d427d520300> <http://xmlns.com/foaf/0.1/name> "Theresa Zesiewicz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9b13c89bb4ddc99a333d0d487e267cf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d9b13c89bb4ddc99a333d0d487e267cf> <http://xmlns.com/foaf/0.1/givenName> "Caterina"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9b13c89bb4ddc99a333d0d487e267cf> <http://xmlns.com/foaf/0.1/familyName> "Mariotti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9b13c89bb4ddc99a333d0d487e267cf> <http://xmlns.com/foaf/0.1/name> "Caterina Mariotti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-34a7d22e2386abbc076858472cb56167> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-34a7d22e2386abbc076858472cb56167> <http://xmlns.com/foaf/0.1/givenName> "Wolfgang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-34a7d22e2386abbc076858472cb56167> <http://xmlns.com/foaf/0.1/familyName> "Nachbauer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-34a7d22e2386abbc076858472cb56167> <http://xmlns.com/foaf/0.1/name> "Wolfgang Nachbauer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d76a8e8acada9e7a81486f5c9c4d321a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d76a8e8acada9e7a81486f5c9c4d321a> <http://xmlns.com/foaf/0.1/givenName> "Megan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d76a8e8acada9e7a81486f5c9c4d321a> <http://xmlns.com/foaf/0.1/familyName> "O'Grady"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d76a8e8acada9e7a81486f5c9c4d321a> <http://xmlns.com/foaf/0.1/name> "Megan O'Grady"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2de86ed7475d3a96c5f4a252284b17e5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2de86ed7475d3a96c5f4a252284b17e5> <http://xmlns.com/foaf/0.1/givenName> "SH"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2de86ed7475d3a96c5f4a252284b17e5> <http://xmlns.com/foaf/0.1/familyName> "Subramony"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2de86ed7475d3a96c5f4a252284b17e5> <http://xmlns.com/foaf/0.1/name> "SH Subramony"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e5c8267d5ba971f1a1b4e0e68e6fa83b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e5c8267d5ba971f1a1b4e0e68e6fa83b> <http://xmlns.com/foaf/0.1/givenName> "Sylvia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e5c8267d5ba971f1a1b4e0e68e6fa83b> <http://xmlns.com/foaf/0.1/familyName> "Boesch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e5c8267d5ba971f1a1b4e0e68e6fa83b> <http://xmlns.com/foaf/0.1/name> "Sylvia Boesch"^^<http://www.w3.org/2001/XMLSchema#string> .
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