eprintid: 10159924
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/15/99/24
datestamp: 2022-11-22 11:44:35
lastmod: 2022-11-22 11:44:35
status_changed: 2022-11-22 11:44:35
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Rook, Graham AW
title: Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D15
keywords: brain development, evolutionary biology, immune dysfunction, immune regulation, microbiota, socioeconomic status
note: © 2022 Rook. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/).
abstract: Healthy development and function of essentially all physiological systems and organs, including the brain, require exposure to the microbiota of our mothers and of the natural environment, especially in early life. We also know that some infections, if we survive them, modulate the immune system in relevant ways. If we study the evolution of the immune and metabolic systems, we can understand how these requirements developed and the nature of the organisms that we need to encounter. We can then begin to identify the mechanisms of the beneficial effects of these exposures. Against this evolutionary background, we can analyze the ways in which the modern urban lifestyle, particularly for individuals experiencing low socioeconomic status (SES), results in deficient or distorted microbial exposures and microbiomes. Thus, an evolutionary approach facilitates the identification of practical solutions to the growing scandal of health disparities linked to inequality.
date: 2022-04-26
date_type: published
publisher: AMER SOC MICROBIOLOGY
official_url: http://doi.org/10.1128/msystems.01438-21
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1945706
doi: 10.1128/msystems.01438-21
medium: Print-Electronic
lyricists_name: Rook, Graham
lyricists_id: GAWRO15
actors_name: Rook, Graham
actors_id: GAWRO15
actors_role: owner
full_text_status: public
publication: mSystems
volume: 7
number: 2
article_number: e01438-21
pages: 17
event_location: United States
citation:        Rook, Graham AW;      (2022)    Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality.                   mSystems , 7  (2)    , Article e01438-21.  10.1128/msystems.01438-21 <https://doi.org/10.1128/msystems.01438-21>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10159924/1/Rook_mSystems_SES%20health%20deficit%20microbiota_22.pdf