eprintid: 10159807
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/98/07
datestamp: 2022-11-18 15:36:45
lastmod: 2022-11-18 15:36:45
status_changed: 2022-11-18 15:36:45
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Wright, Isaac Hempstead
creators_name: Sekar, Akila
creators_name: Jensen, Marte Theilmann
creators_name: Hodgson, Megan
creators_name: Bancroft, Matthew J
creators_name: Koohi, Nehzat
creators_name: Lees, Andrew J
creators_name: Morris, Huw R
creators_name: Kaski, Diego
title: Reflexive and volitional saccadic eye movements and their changes in age and progressive supranuclear palsy
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Eye movements, PSP, Reflexive, Saccades, Volitional
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abstract: BACKGROUND AND OBJECTIVES: Saccades, rapid movements of the eyes towards a visual or remembered target, are useful in understanding the healthy brain and the pathology of neurological conditions such as progressive supranuclear palsy (PSP). We set out to investigate the parameters of horizontal reflexive and volitional saccades, both visually guided and memory-guided, over a 1 min epoch in healthy individuals and PSP patients. METHODS: An experimental paradigm tested reflexive, volitional visually guided, and volitional memory-guided saccades in young healthy controls (n = 14; 20-31 years), PSP patients (n = 11; 46-75 years) and older age-matched healthy controls (n = 6; 56-71 years). The accuracy and velocity of saccades was recorded using an EyeBrain T2® video eye tracker and analyses performed using the MyEyeAnalysis® software. Two-way analysis of variance (ANOVA) was used to identify significant effects (p < 0.01) between young and older controls to investigate the effects of ageing upon saccades, and between PSP patients and age-matched controls to study the effects of PSP upon saccades. RESULTS: In both healthy individuals and PSP patients, volitional saccades are slower and less accurate than reflexive saccades. In PSP patients, accuracy is lower across all saccade types compared to age-matched controls, but velocity is lower only for reflexive saccades. Crucially, there is no change in accuracy or velocity of consecutive saccades over short (one-minute) timescales in controls or PSP patients. CONCLUSIONS: Velocity and accuracy of saccades in PSP does not decrease over one-minute timescales, contrary to that previously observed in Parkinson's Disease (PD), suggesting a potential clinical biomarker for the distinction of PSP from PD.
date: 2022-10-28
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.jns.2022.120482
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1988072
doi: 10.1016/j.jns.2022.120482
medium: Print-Electronic
pii: S0022-510X(22)00344-6
lyricists_name: Lees, Andrew
lyricists_name: Kaski, Diego
lyricists_name: Morris, Huw
lyricists_id: AJLEE60
lyricists_id: DKASK15
lyricists_id: HRMOR79
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of the Neurological Sciences
volume: 443
article_number: 120482
event_location: Netherlands
citation:        Wright, Isaac Hempstead;    Sekar, Akila;    Jensen, Marte Theilmann;    Hodgson, Megan;    Bancroft, Matthew J;    Koohi, Nehzat;    Lees, Andrew J;         ... Kaski, Diego; + view all <#>        Wright, Isaac Hempstead;  Sekar, Akila;  Jensen, Marte Theilmann;  Hodgson, Megan;  Bancroft, Matthew J;  Koohi, Nehzat;  Lees, Andrew J;  Morris, Huw R;  Kaski, Diego;   - view fewer <#>    (2022)    Reflexive and volitional saccadic eye movements and their changes in age and progressive supranuclear palsy.                   Journal of the Neurological Sciences , 443     , Article 120482.  10.1016/j.jns.2022.120482 <https://doi.org/10.1016/j.jns.2022.120482>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10159807/1/1-s2.0-S0022510X22003446-main.pdf