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<https://discovery.ucl.ac.uk/id/eprint/10159329> <http://purl.org/dc/terms/title> "A genome-wide association study of the frailty index highlights brain pathways in ageing"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10159329> <http://purl.org/ontology/bibo/abstract> "Frailty is a common geriatric syndrome and strongly associated with disability, mortality and hospitalization. Frailty is commonly measured using the frailty index (FI), based on the accumulation of a number of health deficits during the life course. The mechanisms underlying FI are multifactorial and not well understood, but a genetic basis has been suggested with heritability estimates between 30 and 45%. Understanding the genetic determinants and biological mechanisms underpinning FI may help to delay or even prevent frailty. We performed a genome-wide association study (GWAS) meta-analysis of a frailty index in European descent UK Biobank participants (n = 164,610, 60–70 years) and Swedish TwinGene participants (n = 10,616, 41–87 years). FI calculation was based on 49 or 44 self-reported items on symptoms, disabilities and diagnosed diseases for UK Biobank and TwinGene, respectively. 14 loci were associated with the FI (p < 5*10−8). Many FI-associated loci have established associations with traits such as body mass index, cardiovascular disease, smoking, HLA proteins, depression and neuroticism; however, one appears to be novel. The estimated single nucleotide polymorphism (SNP) heritability of the FI was 11% (0.11, SE 0.005). In enrichment analysis, genes expressed in the frontal cortex and hippocampus were significantly downregulated (adjusted p < 0.05). We also used Mendelian randomization to identify modifiable traits and exposures that may affect frailty risk, with a higher educational attainment genetic risk score being associated with a lower degree of frailty. Risk of frailty is influenced by many genetic factors, including well-known disease risk factors and mental health, with particular emphasis on pathways in the brain."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10159329> <http://purl.org/dc/terms/date> "2021-09" .
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<https://discovery.ucl.ac.uk/id/eprint/10159329> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10159329#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10159329> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a2d148cfbb831ec5376d4f34cdae0544> .
<https://discovery.ucl.ac.uk/id/eprint/10159329> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10159329#authors> .
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<https://discovery.ucl.ac.uk/id/person/ext-a107ed69be98408030ef29ea5e1c02c9> <http://xmlns.com/foaf/0.1/givenName> "Patrik K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a107ed69be98408030ef29ea5e1c02c9> <http://xmlns.com/foaf/0.1/familyName> "Magnusson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a107ed69be98408030ef29ea5e1c02c9> <http://xmlns.com/foaf/0.1/name> "Patrik K Magnusson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33fef58518b00c481fb0930ab313a80d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-33fef58518b00c481fb0930ab313a80d> <http://xmlns.com/foaf/0.1/givenName> "Luke C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33fef58518b00c481fb0930ab313a80d> <http://xmlns.com/foaf/0.1/familyName> "Pilling"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33fef58518b00c481fb0930ab313a80d> <http://xmlns.com/foaf/0.1/name> "Luke C Pilling"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-62420d137dfe76089e333378f871190c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-62420d137dfe76089e333378f871190c> <http://xmlns.com/foaf/0.1/givenName> "Janice L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-62420d137dfe76089e333378f871190c> <http://xmlns.com/foaf/0.1/familyName> "Atkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-62420d137dfe76089e333378f871190c> <http://xmlns.com/foaf/0.1/name> "Janice L Atkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-61ecfc7f441068834b83d89a782d5d17> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-61ecfc7f441068834b83d89a782d5d17> <http://xmlns.com/foaf/0.1/givenName> "Sara"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-61ecfc7f441068834b83d89a782d5d17> <http://xmlns.com/foaf/0.1/familyName> "Hagg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-61ecfc7f441068834b83d89a782d5d17> <http://xmlns.com/foaf/0.1/name> "Sara Hagg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998ed9db78c20c26f7219064840f12c4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-998ed9db78c20c26f7219064840f12c4> <http://xmlns.com/foaf/0.1/givenName> "David"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998ed9db78c20c26f7219064840f12c4> <http://xmlns.com/foaf/0.1/familyName> "Melzer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998ed9db78c20c26f7219064840f12c4> <http://xmlns.com/foaf/0.1/name> "David Melzer"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-3ed573a2bb2243c78be118568af5b8e2> <http://xmlns.com/foaf/0.1/givenName> "Nancy L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3ed573a2bb2243c78be118568af5b8e2> <http://xmlns.com/foaf/0.1/familyName> "Pedersen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3ed573a2bb2243c78be118568af5b8e2> <http://xmlns.com/foaf/0.1/name> "Nancy L Pedersen"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-a2d148cfbb831ec5376d4f34cdae0544> <http://xmlns.com/foaf/0.1/givenName> "Dylan M"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-8d0e785848a880400ee333dc63cd2632> <http://xmlns.com/foaf/0.1/givenName> "Yunzhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8d0e785848a880400ee333dc63cd2632> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8d0e785848a880400ee333dc63cd2632> <http://xmlns.com/foaf/0.1/name> "Yunzhang Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
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