TY  - JOUR
UR  - https://doi.org/10.1007/s10689-021-00275-9
SP  - 363
KW  - PTEN
KW  -  Cowden syndrome
KW  -  Vulval fibroadenoma
KW  -  Ectopic breast tissue
KW  -  PTEN hamartoma tumour syndrome
TI  - Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SN  - 1389-9600
ID  - discovery10158482
AV  - public
EP  - 368
JF  - Familial Cancer
N2  - PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes.
VL  - 21
A1  - Dawson, Hannah
A1  - Smrke, Alannah
A1  - Ellery, Peter M
A1  - Wilkinson, Nafisa
A1  - Rosenthal, Adam N
A1  - McVeigh, Terri P
Y1  - 2022/07//
PB  - SPRINGER
ER  -