eprintid: 10158112
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/15/81/12
datestamp: 2022-10-27 11:23:14
lastmod: 2022-10-27 11:23:14
status_changed: 2022-10-27 11:23:14
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Ramadhan, Mouhammed
creators_name: Schrag, Anette
creators_name: and the CLaSP Consortium, 
title: The Validity of Health-Related Quality of Life Instruments in Patients With Late-Stage Parkinson's Disease
ispublished: inpress
divisions: C07
divisions: F84
divisions: B02
divisions: UCL
divisions: D07
keywords: Brain, dementia, demqol, neurodegeneration, parkinson’s disease, scale
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abstract: OBJECTIVE: To examine the validity of health-related quality of life (Hr-QoL) measures in patients with late-stage Parkinson's disease (PD). METHODS: We analysed data from patients with late-stage PD and their carers who were assessed with a range of clinical measures and the EQ-5D-3 L. The DEMQOL-Proxy was completed for 157 patients with a diagnosis of dementia and the PDQ-8 by 401 patients without dementia. Convergent validity was assessed using correlations with measures of Parkinson's severity, independence and cognitive function, and construct validity using correlations with patients' own EQ-5D-3 L scores. In addition, we assessed divergent validity using correlations with carers' own EQ-5D index, EQ-VAS and Zarit caregiver burden scores. RESULTS: In patients without dementia, both the PDQ-8 and EQ-5D-3 L correlated with measures of disease severity, dependence and carer burden scores, and PDQ-8 scores moderately with EQ-5D-3 L and EQ-5D-3 L VAS scores. In patients with dementia, EQ-5D-3 L scores correlated with disease severity, cognition and dependence scores, but DEMQOL-Proxy scores were moderately associated only with patients' dependence and carers' own EQ-5D-3 L scores but not patients' disease severity, EQ-5D-3 L or cognitive scores. CONCLUSIONS: The PDQ-8 and EQ-5D-3 L have adequate validity in late stage PD without dementia, but in those with PD and dementia the EQ-5D-3 L may be preferable to the DEMQOL-Proxy.
date: 2022-10-20
date_type: published
publisher: SAGE Publications
official_url: https://doi.org/10.1177/08919887221119963
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1983730
doi: 10.1177/08919887221119963
medium: Print-Electronic
lyricists_name: Schrag, Anette
lyricists_id: AESCH71
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of Geriatric Psychiatry and Neurology
event_location: United States
citation:        Ramadhan, Mouhammed;    Schrag, Anette;    and the CLaSP Consortium;      (2022)    The Validity of Health-Related Quality of Life Instruments in Patients With Late-Stage Parkinson's Disease.                   Journal of Geriatric Psychiatry and Neurology        10.1177/08919887221119963 <https://doi.org/10.1177/08919887221119963>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10158112/1/08919887221119963.pdf