<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10158025> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/title> "Investigation of MicroRNA-134 as a Target against Seizures and SUDEP in a Mouse Model of Dravet Syndrome"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/abstract> "Dravet syndrome (DS) is a catastrophic form of pediatric epilepsy mainly caused by noninherited mutations in the SCN1A gene. DS patients suffer severe and life-threatening focal and generalized seizures which are often refractory to available anti-seizure medication. Antisense oligonucleotides (ASOs) based approaches may offer treatment opportunities in DS. MicroRNAs are short noncoding RNAs that play a key role in brain structure and function by post-transcriptionally regulating gene expression, including ion channels. Inhibiting miRNA-134 (miR-134) using an antimiR ASO (Ant-134) has been shown to reduce evoked seizures in juvenile and adult mice and reduce epilepsy development in models of focal epilepsy. The present study investigated the levels of miR-134 and whether Ant-134 could protect against hyperthermia-induced seizures, spontaneous seizures and mortality (SUDEP) in F1.Scn1a(1/)tm1kea mice. At P17, animals were intracerebroventricular in-jected with 0.1–1 nmol of Ant-134 and subject to a hyperthermia challenge at postnatal day (P)18. A second cohort of P21 F1.Scn1a(1/)tm1kea mice received Ant-134 and were followed by video and EEG monitoring until P28 to track the incidence of spontaneous seizures and SUDEP. Hippocampal and cortical levels of miR-134 were similar between wild-type (WT) and F1.Scn1a(1/)tm1kea mice. Moreover, Ant-134 had no effect on hyperthermia-induced seizures, spontaneous seizures and SUDEP incidence were unchanged in Ant-134-treated DS mice. These findings suggest that targeting miR-134 does not have therapeutic applications in DS."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/date> "2022-10" . <https://discovery.ucl.ac.uk/id/document/1514651> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/volume> "9" . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/issue> "5" . <https://discovery.ucl.ac.uk/id/org/ext-9e5691510dd79225e14a7a9179f0e58a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-9e5691510dd79225e14a7a9179f0e58a> <http://xmlns.com/foaf/0.1/name> "Society for Neuroscience"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/publisher> 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<https://discovery.ucl.ac.uk/id/eprint/10158025#authors> . <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-2fde863ada2c09878f5ba730db0bed36> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-73b14109877e33f3ded79a4732bc3791> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> . <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-73b14109877e33f3ded79a4732bc3791> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4eed61df5ce46c4e204cd486873069e5> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> . <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-4eed61df5ce46c4e204cd486873069e5> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-342500b679e18ed1895d30578c8a0b84> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> . <https://discovery.ucl.ac.uk/id/eprint/10158025#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-342500b679e18ed1895d30578c8a0b84> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4b8aa429e56c8aef92172a068eeb43f3> . <https://discovery.ucl.ac.uk/id/eprint/10158025> <http://purl.org/ontology/bibo/authorList> 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<http://xmlns.com/foaf/0.1/givenName> "DC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d6e11731cc3ff300b9475981601009ef> <http://xmlns.com/foaf/0.1/familyName> "Henshall"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d6e11731cc3ff300b9475981601009ef> <http://xmlns.com/foaf/0.1/name> "DC Henshall"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2fde863ada2c09878f5ba730db0bed36> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2fde863ada2c09878f5ba730db0bed36> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2fde863ada2c09878f5ba730db0bed36> <http://xmlns.com/foaf/0.1/familyName> "Morris"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2fde863ada2c09878f5ba730db0bed36> <http://xmlns.com/foaf/0.1/name> "G Morris"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73b14109877e33f3ded79a4732bc3791> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-73b14109877e33f3ded79a4732bc3791> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73b14109877e33f3ded79a4732bc3791> <http://xmlns.com/foaf/0.1/familyName> "Campbell"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73b14109877e33f3ded79a4732bc3791> <http://xmlns.com/foaf/0.1/name> "A Campbell"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-342500b679e18ed1895d30578c8a0b84> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-342500b679e18ed1895d30578c8a0b84> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-342500b679e18ed1895d30578c8a0b84> <http://xmlns.com/foaf/0.1/familyName> "Langa"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-342500b679e18ed1895d30578c8a0b84> <http://xmlns.com/foaf/0.1/name> "E Langa"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4eed61df5ce46c4e204cd486873069e5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4eed61df5ce46c4e204cd486873069e5> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4eed61df5ce46c4e204cd486873069e5> <http://xmlns.com/foaf/0.1/familyName> "Worm"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4eed61df5ce46c4e204cd486873069e5> <http://xmlns.com/foaf/0.1/name> "J Worm"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-068f638200a5ad7a39a3eceb96f1ca60> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-068f638200a5ad7a39a3eceb96f1ca60> <http://xmlns.com/foaf/0.1/givenName> "RR"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-068f638200a5ad7a39a3eceb96f1ca60> <http://xmlns.com/foaf/0.1/familyName> "Gerbatin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-068f638200a5ad7a39a3eceb96f1ca60> <http://xmlns.com/foaf/0.1/name> "RR Gerbatin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7ca015ca599142c55d0cf015656e06cf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7ca015ca599142c55d0cf015656e06cf> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7ca015ca599142c55d0cf015656e06cf> <http://xmlns.com/foaf/0.1/familyName> "Augusto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7ca015ca599142c55d0cf015656e06cf> <http://xmlns.com/foaf/0.1/name> "J Augusto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4b8aa429e56c8aef92172a068eeb43f3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4b8aa429e56c8aef92172a068eeb43f3> <http://xmlns.com/foaf/0.1/givenName> "CR"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4b8aa429e56c8aef92172a068eeb43f3> <http://xmlns.com/foaf/0.1/familyName> "Reschke"^^<http://www.w3.org/2001/XMLSchema#string> 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