<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10157670> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/title> "Effect of vitamin D supplementation in patients with chronic hepatitis C after direct-Acting antiviral treatment a randomized, double-blind, placebo-controlled trial"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/abstract> "Background Replacement of vitamin D (VD) among patients with chronic hepatitis C (CHC) before viral eradication has demonstrated a protective effect on serum markers associated with hepatic fibrogenesis. We therefore hypothesized that VD may facilitate further fibrosis amelioration following curative treatment with direct-Acting antivirals (DAA). Methods. This study was a randomized, double-blind, placebo-controlled trial con-ducted between February 2018 and August 2018. Patients with CHC and VD deficiency were randomized in a 1:1 ratio to either receive ergicalciferol or placebo over 6 weeks. Biochemical analysis indicators, including 25-hydroxyvitamin D (25(OH)D), fibrogenic markers [(transforming growth factor beta 1 (TGF-1) and tissue in-hibitors of matrix metalloproteinases 1 (TIMP-1)], and fibrolytic markers [matrix metalloproteinase 9 (MMP-9) and amino terminal type III procollagen peptide (P3NP)], were assessed at baseline and at 6 weeks. Serum 25(OH)D was analyzed by a chemiluminescence immunoassay. Serum hepatic fibrogenesis markers were measured using a quantitative sandwich enzyme-linked immunosorbent assay. Results. Seventy-five patients with CHC and VD deficiency were randomly assigned to VD (nD37) and placebo (nD38) groups. At the end of the study, the mean serum 25(OH)D level had risen to a normal level in the VD group, but was still deficient in the placebo group (41.8 9.1 vs. 18.1 4.6 ng/mL, p 0.001). Upon restoration of the VD level, there were no significant mean differences in the change from baseline for TGF-1 (0.6 ng/mL (95% confidence interval (95% CI) [2.81.7]), pD0:63), TIMP-1 (5.5 ng/mL (95% CI [26.4 15.3]), pD0:60), MMP-9 (122.9 ng/mL (95% CI [69.0 314.8]), pD0:21), and P3NP (0.1 ng/mL (95% CI [2.4 2.2]), pD0:92) between the VD and placebo groups. Conclusion. Short-Term VD supplementation after DAA treatment in patients with CHC does not improve serum fibrogenesis markers and may not expedite the residual liver fibrosis healing process. Future studies are warranted to evaluate the long-Term effect of VD supplementation on hepatic fibrosis regression."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/date> "2021-02-09" .
<https://discovery.ucl.ac.uk/id/document/1514218> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/volume> "9" .
<https://discovery.ucl.ac.uk/id/org/ext-aeefe6f008630d9d389ba4c4af6528f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-aeefe6f008630d9d389ba4c4af6528f5> <http://xmlns.com/foaf/0.1/name> "PeerJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-aeefe6f008630d9d389ba4c4af6528f5> .
<https://discovery.ucl.ac.uk/id/publication/ext-21678359> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-21678359> <http://xmlns.com/foaf/0.1/name> "PeerJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-21678359> .
<https://discovery.ucl.ac.uk/id/publication/ext-21678359> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:21678359> .
<https://discovery.ucl.ac.uk/id/publication/ext-21678359> <http://purl.org/ontology/bibo/issn> "21678359" .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-42f01bedf874c6ca9d1726e36e6ab8e3> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-42f01bedf874c6ca9d1726e36e6ab8e3> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6bae776895bb8022d2009591f3b37be7> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-6bae776895bb8022d2009591f3b37be7> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1456432fea35f157c0187a9f092ed131> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-1456432fea35f157c0187a9f092ed131> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-781fb7003288e33078c4628f8da0d9f6> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-781fb7003288e33078c4628f8da0d9f6> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bdcac1f8fb27ec70c12427fd44907efd> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-bdcac1f8fb27ec70c12427fd44907efd> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d47179181cda2c6345a3d8ccf7255457> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-d47179181cda2c6345a3d8ccf7255457> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e055309b384f33e00834ac4b3bbf05d5> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-e055309b384f33e00834ac4b3bbf05d5> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fad86884e09b0dd146e90c125f3c6421> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-fad86884e09b0dd146e90c125f3c6421> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f5587fde4e36ed526be3d69b6cf8a95b> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-f5587fde4e36ed526be3d69b6cf8a95b> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4f3cb282b87af93a93781a223c7e1d89> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-4f3cb282b87af93a93781a223c7e1d89> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e1bcaea24616d442e6d24577dd02837e> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e1bcaea24616d442e6d24577dd02837e> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3879f0ce5317f8f882a08ee09a509468> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-3879f0ce5317f8f882a08ee09a509468> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7cf0674c7946ff64cc9f3dc6ca37bed0> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-7cf0674c7946ff64cc9f3dc6ca37bed0> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-79ef69bce0193e2194f04cb1171c470c> .
<https://discovery.ucl.ac.uk/id/eprint/10157670> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10157670#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10157670#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-79ef69bce0193e2194f04cb1171c470c> .
<https://discovery.ucl.ac.uk/id/person/ext-bdcac1f8fb27ec70c12427fd44907efd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-bdcac1f8fb27ec70c12427fd44907efd> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bdcac1f8fb27ec70c12427fd44907efd> <http://xmlns.com/foaf/0.1/familyName> "Thaimai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bdcac1f8fb27ec70c12427fd44907efd> <http://xmlns.com/foaf/0.1/name> "P Thaimai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3879f0ce5317f8f882a08ee09a509468> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3879f0ce5317f8f882a08ee09a509468> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3879f0ce5317f8f882a08ee09a509468> <http://xmlns.com/foaf/0.1/familyName> "Treeprasertsuk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3879f0ce5317f8f882a08ee09a509468> <http://xmlns.com/foaf/0.1/name> "S Treeprasertsuk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e1bcaea24616d442e6d24577dd02837e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e1bcaea24616d442e6d24577dd02837e> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e1bcaea24616d442e6d24577dd02837e> <http://xmlns.com/foaf/0.1/familyName> "Chaopathomkul"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e1bcaea24616d442e6d24577dd02837e> <http://xmlns.com/foaf/0.1/name> "B Chaopathomkul"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e055309b384f33e00834ac4b3bbf05d5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e055309b384f33e00834ac4b3bbf05d5> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e055309b384f33e00834ac4b3bbf05d5> <http://xmlns.com/foaf/0.1/familyName> "Sonsiri"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e055309b384f33e00834ac4b3bbf05d5> <http://xmlns.com/foaf/0.1/name> "K Sonsiri"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fad86884e09b0dd146e90c125f3c6421> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fad86884e09b0dd146e90c125f3c6421> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fad86884e09b0dd146e90c125f3c6421> <http://xmlns.com/foaf/0.1/familyName> "Srisoonthorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fad86884e09b0dd146e90c125f3c6421> <http://xmlns.com/foaf/0.1/name> "N Srisoonthorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-42f01bedf874c6ca9d1726e36e6ab8e3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-42f01bedf874c6ca9d1726e36e6ab8e3> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-42f01bedf874c6ca9d1726e36e6ab8e3> <http://xmlns.com/foaf/0.1/familyName> "Sriphoosanaphan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-42f01bedf874c6ca9d1726e36e6ab8e3> <http://xmlns.com/foaf/0.1/name> "S Sriphoosanaphan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4f3cb282b87af93a93781a223c7e1d89> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4f3cb282b87af93a93781a223c7e1d89> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4f3cb282b87af93a93781a223c7e1d89> <http://xmlns.com/foaf/0.1/familyName> "Tanpowpong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4f3cb282b87af93a93781a223c7e1d89> <http://xmlns.com/foaf/0.1/name> "N Tanpowpong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5587fde4e36ed526be3d69b6cf8a95b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f5587fde4e36ed526be3d69b6cf8a95b> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5587fde4e36ed526be3d69b6cf8a95b> <http://xmlns.com/foaf/0.1/familyName> "Teeratorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5587fde4e36ed526be3d69b6cf8a95b> <http://xmlns.com/foaf/0.1/name> "N Teeratorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf0674c7946ff64cc9f3dc6ca37bed0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf0674c7946ff64cc9f3dc6ca37bed0> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf0674c7946ff64cc9f3dc6ca37bed0> <http://xmlns.com/foaf/0.1/familyName> "Poovorawan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7cf0674c7946ff64cc9f3dc6ca37bed0> <http://xmlns.com/foaf/0.1/name> "Y Poovorawan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1456432fea35f157c0187a9f092ed131> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1456432fea35f157c0187a9f092ed131> <http://xmlns.com/foaf/0.1/givenName> "SJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1456432fea35f157c0187a9f092ed131> <http://xmlns.com/foaf/0.1/familyName> "Kerr"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1456432fea35f157c0187a9f092ed131> <http://xmlns.com/foaf/0.1/name> "SJ Kerr"^^<http://www.w3.org/2001/XMLSchema#string> .
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