TY - JOUR N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. Y1 - 2023/06// TI - Longitudinal Assessment of the Enhanced Liver Fibrosis Score in the Era of Contemporary HIV and Hepatitis C Virus Treatment IS - 11 N2 - BACKGROUND: The trajectory of liver fibrosis is not well understood in the contemporary era of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) therapy. METHODS: We assessed the Enhanced Liver Fibrosis (ELF) score, aspartate transaminase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) in 116 women with HIV/HCV coinfection over a 4-year period. Random-effects linear regression models examined the rate of fibrosis change 1-2 years before starting HCV treatment, within 1 year before starting (peri-HCV treatment), within 1 year after and 1-2 years post-HCV treatment in unadjusted and adjusted models including age, race, and changes from pretreatment of factors that might affect fibrosis (eg, alcohol, integrase strand inhibitor [INSTI] use, waist circumference, CD4 count). RESULTS: INSTI use nearly doubled from pre- to peri-HCV treatment. In unadjusted analysis, there was a 3.3% rate of rise in ELF pre-HCV treatment, 2.2% and 3.6% rate of decline during the peri- and 1-year post-HCV treatment period, respectively, followed by a 0.3% rise. Similar findings were observed for APRI and FIB-4. There was little effect on the estimated fibrosis trajectories after adjustment. CONCLUSIONS: The apparent lack of decline in biomarkers of liver fibrosis beyond 1 year after HCV cure suggests that continued monitoring of liver fibrosis and interventions to mitigate progression in people with HIV after HCV cure remains essential. VL - 227 SN - 0022-1899 EP - 1281 SP - 1274 ID - discovery10157002 PB - Oxford University Press (OUP) JF - Journal of Infectious Diseases KW - APRI KW - ELF KW - FIB-4 KW - HIV KW - direct-acting antiviral therapy KW - enhanced liver fibrosis score KW - hepatitis C UR - https://doi.org/10.1093/infdis/jiac315 A1 - Gardner, Annelys Roque A1 - Ma, Yifei A1 - Bacchetti, Peter A1 - Price, Jennifer C A1 - Kuniholm, Mark H A1 - French, Audrey L A1 - Gange, Stephen A1 - Adimora, Adaora A A1 - Minkoff, Howard A1 - Kassaye, Seble A1 - Ofotokun, Igho A1 - Rosenberg, William A1 - Kovacs, Andrea AZ A1 - Tien, Phyllis C AV - public ER -