eprintid: 10156980
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/69/80
datestamp: 2022-10-10 07:40:46
lastmod: 2022-10-10 07:40:46
status_changed: 2022-10-10 07:40:46
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Kennedy, DO
creators_name: Bonnländer, B
creators_name: Lang, SC
creators_name: Pischel, I
creators_name: Forster, J
creators_name: Khan, J
creators_name: Jackson, PA
creators_name: Wightman, EL
title: Acute and chronic effects of green oat (Avena sativa) extract on cognitive function and mood during a laboratory stressor in healthy adults: A randomised, double-blind, placebo-controlled study in healthy humans
ispublished: pub
divisions: C08
divisions: D10
divisions: B02
divisions: UCL
keywords: Avena sativa, brain, cognition, green oat extract, phytochemicals, polyphenols, stress, triterpenes, working memory, Adult, Affect, Aged, Avena, Cognition, Dietary Supplements, Dose-Response Relationship, Drug, Double-Blind Method, Healthy Volunteers, Humans, Male, Memory, Middle Aged, Phytochemicals, Plant Extracts, Psychomotor Performance, Saponins, Stress, Psychological, Time Factors, Triterpenes
note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Green oat (Avena sativa) extracts contain several groups of potentially psychoactive phytochemicals. Previous research has demonstrated improvements in cognitive function following a single dose of these extracts, but not following chronic supplementation. Additionally, whilst green oat extracts contain phytochemicals that may improve mood or protect against stress, for instance species-specific triterpene saponins, to date this possibility has not been examined. The current study investigated the effects of a single dose and four weeks of administration of a novel, Avena sativa herbal extract (cognitaven®) on cognitive function and mood, and changes in psychological state during a laboratory stressor. The study adopted a dose-ranging, double-blind, randomised, parallel groups design in which 132 healthy males and females (35 to 65 years) received either 430 mg, 860 mg, 1290 mg green oat extract or placebo for 29 days. Assessments of cognitive function, mood and changes in psychological state during a laboratory stressor (Observed Multitasking Stressor) were undertaken pre-dose and at 2 h and 4 h post-dose on the first (Day 1) and last days (Day 29) of supplementation. The results showed that both a single dose of 1290 mg and, to a greater extent, supplementation for four weeks with both 430 mg and 1290 mg green oat extract resulted in significantly improved performance on a computerised version of the Corsi Blocks working memory task and a multitasking task (verbal serial subtractions and computerised tracking) in comparison to placebo. After four weeks, the highest dose also decreased the physiological response to the stressor in terms of electrodermal activity. There were no treatment-related effects on mood. These results confirm the acute cognitive effects of Avena sativa extracts and are the first to demonstrate that chronic supplementation can benefit cognitive function and modulate the physiological response to a stressor.
date: 2020-06-01
date_type: published
publisher: MDPI AG
official_url: http://dx.doi.org/10.3390/nu12061598
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1981047
doi: 10.3390/nu12061598
medium: Electronic
pii: nu12061598
lyricists_name: Pischel, Ivo
lyricists_id: IPISC81
actors_name: Pischel, Ivo
actors_name: Harris, Jean
actors_id: IPISC81
actors_id: JAHAR68
actors_role: owner
actors_role: impersonator
funding_acknowledgements: na [Anklam Extrakt GmbH]
full_text_status: public
publication: Nutrients
volume: 12
number: 6
article_number: e1598
event_location: Switzerland
citation:        Kennedy, DO;    Bonnländer, B;    Lang, SC;    Pischel, I;    Forster, J;    Khan, J;    Jackson, PA;           Kennedy, DO;  Bonnländer, B;  Lang, SC;  Pischel, I;  Forster, J;  Khan, J;  Jackson, PA;  Wightman, EL;   - view fewer <#>    (2020)    Acute and chronic effects of green oat (Avena sativa) extract on cognitive function and mood during a laboratory stressor in healthy adults: A randomised, double-blind, placebo-controlled study in healthy humans.                   Nutrients , 12  (6)    , Article e1598.  10.3390/nu12061598 <https://doi.org/10.3390/nu12061598>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10156980/1/Acute%20and%20Chronic%20Effects%20of%20Green%20Oat%20%28Avena%20sativa%29%20Extract%20on%20Cognitive%20Function%20and%20Mood%20during%20a%20Laboratory%20Stressor%20in.pdf