eprintid: 10156922 rev_number: 8 eprint_status: archive userid: 699 dir: disk0/10/15/69/22 datestamp: 2022-10-06 09:32:23 lastmod: 2023-09-08 06:10:05 status_changed: 2022-10-06 09:32:23 type: book_section metadata_visibility: show sword_depositor: 699 creators_name: Beato, Marco creators_name: Bhumbra, Gary title: Synaptic Projections of Motoneurons Within the Spinal Cord ispublished: pub divisions: C08 divisions: G02 divisions: B02 divisions: UCL divisions: D09 keywords: Synaptic transmission, Co-release, Glutamate, Acetylcholine, Synaptic connectivity note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Motoneurons have long been considered as the final common pathway of the nervous system, transmitting the neural impulses that are transduced into action.While many studies have focussed on the inputs that motoneurons receive from local circuits within the spinal cord and from other parts of the CNS, relatively few have investigated the targets of local axonal projections from motoneurons themselves, with the notable exception of those contacting Renshaw cells or other motoneurons.Recent research has not only characterised the detailed features of the excitatory connections between motoneurons and Renshaw cells but has also established that Renshaw cells are not the only target of motoneurons axons within the spinal cord. Motoneurons also form synaptic contacts with other motoneurons as well as with a subset of ventrally located V3 interneurons. These findings indicate that motoneurons cannot be simply viewed as the last relay station delivering the command drive to muscles, but perform an active role in the generation and modulation of motor patterns. date: 2022-09-07 date_type: published publisher: Springer official_url: https://doi.org/10.1007/978-3-031-07167-6_7 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1977850 doi: 10.1007/978-3-031-07167-6_7 isbn_13: 9783031071669 medium: Print lyricists_name: Beato, Marco lyricists_id: MBEAT12 actors_name: Beato, Marco actors_name: Allington-Smith, Dominic actors_id: MBEAT12 actors_id: DAALL44 actors_role: owner actors_role: impersonator full_text_status: public series: Advances in Neurobiology (NEUROBIOL) volume: 28 place_of_pub: Cham, Switzerland pagerange: 151-168 book_title: Vertebrate Motoneurons editors_name: O'Donovan, Michael J editors_name: Falgairolle, Mélanie citation: Beato, Marco; Bhumbra, Gary; (2022) Synaptic Projections of Motoneurons Within the Spinal Cord. In: O'Donovan, Michael J and Falgairolle, Mélanie, (eds.) Vertebrate Motoneurons. (pp. 151-168). Springer: Cham, Switzerland. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10156922/1/Beato_mnpsts-revised.pdf