eprintid: 10156922
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/15/69/22
datestamp: 2022-10-06 09:32:23
lastmod: 2023-09-08 06:10:05
status_changed: 2022-10-06 09:32:23
type: book_section
metadata_visibility: show
sword_depositor: 699
creators_name: Beato, Marco
creators_name: Bhumbra, Gary
title: Synaptic Projections of Motoneurons Within the Spinal Cord
ispublished: pub
divisions: C08
divisions: G02
divisions: B02
divisions: UCL
divisions: D09
keywords: Synaptic transmission, Co-release, Glutamate, Acetylcholine, Synaptic connectivity
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Motoneurons have long been considered as the final common pathway of the nervous system, transmitting the neural impulses that are transduced into action.While many studies have focussed on the inputs that motoneurons receive from local circuits within the spinal cord and from other parts of the CNS, relatively few have investigated the targets of local axonal projections from motoneurons themselves, with the notable exception of those contacting Renshaw cells or other motoneurons.Recent research has not only characterised the detailed features of the excitatory connections between motoneurons and Renshaw cells but has also established that Renshaw cells are not the only target of motoneurons axons within the spinal cord. Motoneurons also form synaptic contacts with other motoneurons as well as with a subset of ventrally located V3 interneurons. These findings indicate that motoneurons cannot be simply viewed as the last relay station delivering the command drive to muscles, but perform an active role in the generation and modulation of motor patterns.
date: 2022-09-07
date_type: published
publisher: Springer
official_url: https://doi.org/10.1007/978-3-031-07167-6_7
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1977850
doi: 10.1007/978-3-031-07167-6_7
isbn_13: 9783031071669
medium: Print
lyricists_name: Beato, Marco
lyricists_id: MBEAT12
actors_name: Beato, Marco
actors_name: Allington-Smith, Dominic
actors_id: MBEAT12
actors_id: DAALL44
actors_role: owner
actors_role: impersonator
full_text_status: public
series: Advances in Neurobiology (NEUROBIOL)
volume: 28
place_of_pub: Cham, Switzerland
pagerange: 151-168
book_title: Vertebrate Motoneurons
editors_name: O'Donovan, Michael J
editors_name: Falgairolle, Mélanie
citation:        Beato, Marco;    Bhumbra, Gary;      (2022)    Synaptic Projections of Motoneurons Within the Spinal Cord.                    In: O'Donovan, Michael J and Falgairolle, Mélanie, (eds.) Vertebrate Motoneurons. (pp. 151-168).   Springer: Cham, Switzerland.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10156922/1/Beato_mnpsts-revised.pdf