eprintid: 10156720
rev_number: 10
eprint_status: archive
userid: 699
dir: disk0/10/15/67/20
datestamp: 2022-10-05 11:47:16
lastmod: 2023-09-28 06:10:16
status_changed: 2022-10-05 11:47:16
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Abdel-Mannan, O
creators_name: Venkatesan, TC
creators_name: Sutcliffe, AG
title: Paediatric sudden unexpected death in epilepsy (SUDEP): is it truly unexplained?
ispublished: pub
divisions: C07
divisions: F87
divisions: B02
divisions: UCL
divisions: D07
divisions: G25
divisions: D13
keywords: epidemiology, epilepsy, paediatric sudden unexplained death in epilepsy, risk factors
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Sudden unexpected death in epilepsy (SUDEP) is an increasingly recognized cause of death in children and young people with epilepsy. Although paediatric SUDEP is thought to be a rare event, it may be more common than previously thought, with incidence estimates ranging from 0.22 to 6 per 1000 person years. Limited clinician experience and knowledge about paediatric SUDEP has impaired the ability to inform children and their families about their individual risk and means to reduce it. Although many questions remain, in the past two decades our understanding of paediatric SUDEP has greatly increased. The pathophysiology of paediatric SUDEP remains poorly characterized, with distinct respiratory, cardiac, and central mechanisms all likely to be involved. Recent cohort studies have allowed major risk factors to be identified, including frequent generalized tonic-clonic seizures, nocturnal seizures, and lack of supervision. Optimizing seizure control, alongside the early detection and supervision of seizure activity, are possible risk reduction strategies. Evidenced-based discussions about paediatric SUDEP should form part of routine care for children and young people with epilepsy.
date: 2022-10-01
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.paed.2022.07.010
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1973827
doi: 10.1016/j.paed.2022.07.010
lyricists_name: Abdel-Mannan, Omar
lyricists_name: Sutcliffe, Alastair
lyricists_id: OABDE15
lyricists_id: AGSUT16
actors_name: Abdel-Mannan, Omar
actors_id: OABDE15
actors_role: owner
full_text_status: public
publication: Paediatrics and Child Health
volume: 32
number: 10
pagerange: 382-387
citation:        Abdel-Mannan, O;    Venkatesan, TC;    Sutcliffe, AG;      (2022)    Paediatric sudden unexpected death in epilepsy (SUDEP): is it truly unexplained?                   Paediatrics and Child Health , 32  (10)   pp. 382-387.    10.1016/j.paed.2022.07.010 <https://doi.org/10.1016/j.paed.2022.07.010>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10156720/2/Abdel-Mannan_Paediatric%20sudden%20unexpected%20death%20in%20epilepsy%20%28SUDEP%29_submitted.pdf