eprintid: 10156720 rev_number: 10 eprint_status: archive userid: 699 dir: disk0/10/15/67/20 datestamp: 2022-10-05 11:47:16 lastmod: 2023-09-28 06:10:16 status_changed: 2022-10-05 11:47:16 type: article metadata_visibility: show sword_depositor: 699 creators_name: Abdel-Mannan, O creators_name: Venkatesan, TC creators_name: Sutcliffe, AG title: Paediatric sudden unexpected death in epilepsy (SUDEP): is it truly unexplained? ispublished: pub divisions: C07 divisions: F87 divisions: B02 divisions: UCL divisions: D07 divisions: G25 divisions: D13 keywords: epidemiology, epilepsy, paediatric sudden unexplained death in epilepsy, risk factors note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Sudden unexpected death in epilepsy (SUDEP) is an increasingly recognized cause of death in children and young people with epilepsy. Although paediatric SUDEP is thought to be a rare event, it may be more common than previously thought, with incidence estimates ranging from 0.22 to 6 per 1000 person years. Limited clinician experience and knowledge about paediatric SUDEP has impaired the ability to inform children and their families about their individual risk and means to reduce it. Although many questions remain, in the past two decades our understanding of paediatric SUDEP has greatly increased. The pathophysiology of paediatric SUDEP remains poorly characterized, with distinct respiratory, cardiac, and central mechanisms all likely to be involved. Recent cohort studies have allowed major risk factors to be identified, including frequent generalized tonic-clonic seizures, nocturnal seizures, and lack of supervision. Optimizing seizure control, alongside the early detection and supervision of seizure activity, are possible risk reduction strategies. Evidenced-based discussions about paediatric SUDEP should form part of routine care for children and young people with epilepsy. date: 2022-10-01 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.paed.2022.07.010 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1973827 doi: 10.1016/j.paed.2022.07.010 lyricists_name: Abdel-Mannan, Omar lyricists_name: Sutcliffe, Alastair lyricists_id: OABDE15 lyricists_id: AGSUT16 actors_name: Abdel-Mannan, Omar actors_id: OABDE15 actors_role: owner full_text_status: public publication: Paediatrics and Child Health volume: 32 number: 10 pagerange: 382-387 citation: Abdel-Mannan, O; Venkatesan, TC; Sutcliffe, AG; (2022) Paediatric sudden unexpected death in epilepsy (SUDEP): is it truly unexplained? Paediatrics and Child Health , 32 (10) pp. 382-387. 10.1016/j.paed.2022.07.010 <https://doi.org/10.1016/j.paed.2022.07.010>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10156720/2/Abdel-Mannan_Paediatric%20sudden%20unexpected%20death%20in%20epilepsy%20%28SUDEP%29_submitted.pdf