Cheng, Suk Fun; van Velzen, Twan J; Gregson, John; Richards, Toby; Jaeger, Hans Rolf; Simister, Robert; Kooi, M Eline; ... Bonati, Leo H; + view all Cheng, Suk Fun; van Velzen, Twan J; Gregson, John; Richards, Toby; Jaeger, Hans Rolf; Simister, Robert; Kooi, M Eline; de Borst, Gert J; Pizzini, Francesca B; Nederkoorn, Paul J; Brown, Martin M; Bonati, Leo H; - view fewer (2022) The 2nd European Carotid Surgery Trial (ECST-2): rationale and protocol for a randomised clinical trial comparing immediate revascularisation versus optimised medical therapy alone in patients with symptomatic and asymptomatic carotid stenosis at low to intermediate risk of stroke. Trials , 23 (1) , Article 606. 10.1186/s13063-022-06429-z.