eprintid: 10154873
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/48/73
datestamp: 2022-09-01 13:46:14
lastmod: 2022-09-01 13:46:14
status_changed: 2022-09-01 13:46:14
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Howard, Rachel
creators_name: Li, Runci
creators_name: Harvey-Jones, Kelly
creators_name: Verma, Vinita
creators_name: Lange, Frédéric
creators_name: Boylan, Geraldine
creators_name: Tachtsidis, Ilias
creators_name: Mitra, Subhabrata
title: Optical Monitoring in Neonatal Seizures
ispublished: pub
divisions: C05
divisions: F42
divisions: B04
divisions: UCL
divisions: G14
divisions: D11
divisions: B02
keywords: neonatal seizures; near infrared spectroscopy; cerebral oxygenation; cerebral haemodynamics; cerebral metabolism
note: This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: BACKGROUND: Neonatal seizures remain a significant cause of morbidity and mortality worldwide. The past decade has resulted in substantial progress in seizure detection and understanding the impact seizures have on the developing brain. Optical monitoring such as cerebral near-infrared spectroscopy (NIRS) and broadband NIRS can provide non-invasive continuous real-time monitoring of the changes in brain metabolism and haemodynamics. AIM: To perform a systematic review of optical biomarkers to identify changes in cerebral haemodynamics and metabolism during the pre-ictal, ictal, and post-ictal phases of neonatal seizures. METHOD: A systematic search was performed in eight databases. The search combined the three broad categories: (neonates) AND (NIRS) AND (seizures) using the stepwise approach following PRISMA guidance. RESULTS: Fifteen papers described the haemodynamic and/or metabolic changes observed with NIRS during neonatal seizures. No randomised controlled trials were identified during the search. Studies reported various changes occurring in the pre-ictal, ictal, and post-ictal phases of seizures. CONCLUSION: Clear changes in cerebral haemodynamics and metabolism were noted during the pre-ictal, ictal, and post-ictal phases of seizures in neonates. Further studies are necessary to determine whether NIRS-based methods can be used at the cot-side to provide clear pathophysiological data in real-time during neonatal seizures.
date: 2022-08-02
date_type: published
publisher: MDPI AG
official_url: https://doi.org/10.3390/cells11162602
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1973487
doi: 10.3390/cells11162602
pii: cells11162602
lyricists_name: Tachtsidis, Ilias
lyricists_name: Mitra, Subhabrata
lyricists_id: ITACH19
lyricists_id: MITRA07
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: 219610/Z/19/Z [The Wellcome Trust]; MR/S003134/1 [Medical Research Council]; [National Institute for Health Research University College London Hospitals Biomedical Research Center]
full_text_status: public
publication: Cells
volume: 11
number: 16
article_number: 2602
event_location: Switzerland
citation:        Howard, Rachel;    Li, Runci;    Harvey-Jones, Kelly;    Verma, Vinita;    Lange, Frédéric;    Boylan, Geraldine;    Tachtsidis, Ilias;           Howard, Rachel;  Li, Runci;  Harvey-Jones, Kelly;  Verma, Vinita;  Lange, Frédéric;  Boylan, Geraldine;  Tachtsidis, Ilias;  Mitra, Subhabrata;   - view fewer <#>    (2022)    Optical Monitoring in Neonatal Seizures.                   Cells , 11  (16)    , Article 2602.  10.3390/cells11162602 <https://doi.org/10.3390/cells11162602>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10154873/1/cells-11-02602-v2.pdf