eprintid: 10153737
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/15/37/37
datestamp: 2022-08-16 13:44:44
lastmod: 2024-11-06 15:15:58
status_changed: 2022-08-16 13:44:44
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Belitsis, Georgios
creators_name: Schievano, Silvia
creators_name: Kostolny, Martin
creators_name: Cook, andrew
title: Aortic Arch Phenotypes in Double Outlet Right Ventricle (DORV)—Implications for Surgery and Multi-Modal Imaging
ispublished: pub
subjects: GOSH
divisions: UCL
divisions: D14
divisions: B02
keywords: Aortic arch; patch aortoplasty; tubular hypoplasia; double outlet right ventricle; DORV; virtual reality; 3D printing
note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Abnormal aortic arches (AAAs) cover a spectrum of malformations, including abnormal laterality, branching patterns, and flow-limiting narrowing, which themselves vary from tubular hypoplasia, through discrete coarctation, to complete interruption of the arch. Neonatal surgery within the first days of life is necessary for most of these morphologies. Patch aortoplasty is widely used as it can offer a good haemodynamic result, being tailored to each combination of presenting pathologies. Our study hypothesis was that arch malformations are frequent in DORV and exhibit a plethora of phenotypes. We reviewed 54 post-mortem heart specimens from the UCL Cardiac Archive, analysing morphological features that would potentially influence the surgical repair, and taking relevant measurements of surgical importance. AAAs were found in half of the specimens, including 22.2% with aortic arch narrowing. In total, 70% and 30% of narrow arches had a subpulmonary and subaortic interventricular defect, respectively. Z-scores were significantly negative for all cases with tubular hypoplasia. We concluded that arch malformations are a common finding among hearts with DORV. Surgery on the neonatal aortic arch in DORV, performed in conjunction with other interventions that aim to balance pulmonary to systemic flow (Qp/Qs), should be anticipated and form an important part of multi-modal imaging.
date: 2022-08
date_type: published
official_url: https://doi.org/10.3390/jcdd9080262
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1970102
doi: 10.3390/jcdd9080262
lyricists_name: Belitsis, Georgios
lyricists_id: GBELI47
actors_name: Belitsis, Georgios
actors_id: GBELI47
actors_role: owner
funding_acknowledgements: G.B. has been supported by the British Heart Foundation (PG/16/99/32572). [University College London]
full_text_status: public
publication: Journal of Cardiovascular Development and Disease
volume: 9
number: 8
article_number: 262
citation:        Belitsis, Georgios;    Schievano, Silvia;    Kostolny, Martin;    Cook, andrew;      (2022)    Aortic Arch Phenotypes in Double Outlet Right Ventricle (DORV)—Implications for Surgery and Multi-Modal Imaging.                   Journal of Cardiovascular Development and Disease , 9  (8)    , Article 262.  10.3390/jcdd9080262 <https://doi.org/10.3390/jcdd9080262>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10153737/1/jcdd-09-00262.pdf