eprintid: 10153472
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/15/34/72
datestamp: 2022-08-09 10:07:36
lastmod: 2022-08-09 10:07:36
status_changed: 2022-08-09 10:07:36
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Maynou, Laia
creators_name: Owen, Rhiannon
creators_name: Konstant-Hambling, Rob
creators_name: Imam, Towhid
creators_name: Arkill, Suzanne
creators_name: Bertfield, Deborah
creators_name: Street, Andrew
creators_name: Abrams, Keith R
creators_name: Conroy, Simon
title: The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people: a national cohort study
ispublished: inpress
divisions: UCL
divisions: D14
divisions: B02
keywords: COVID-19, Frailty, Acute hospital outcomes
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abstract: Introduction: Frailty has emerged as an important construct to support clinical decision-making during the COVID-19 pandemic. However, doubts remain related to methodological limitations of published studies. /

Methods: Retrospective cohort study of all people aged 75 + admitted to hospital in England between 1 March 2020 and 31 July 2021. COVID-19 and frailty risk were captured using International Classification of Disease-10 (ICD-10) diagnostic codes. We used the generalised gamma model to estimate accelerated failure time, reporting unadjusted and adjusted results. /

Results: The cohort comprised 103,561 individuals, mean age 84.1, around half female, 82% were White British with a median of two comorbidities. Frailty risk was distributed approximately 20% low risk and 40% each at intermediate or high risk. In the unadjusted survival plots, 28-day mortality was almost 50% for those with an ICD-10 code of U071 (COVID-19 virus identified), and 25–35% for those with U072 (COVID-19 virus not identified). In the adjusted analysis, the accelerated failure time estimates for those with intermediate and high frailty risk were 0.63 (95% CI 0.58–0.68) and 0.67 (95% CI 0.62–0.72) fewer days alive respectively compared to those with low frailty risk with an ICD-10 diagnosis of U072 (reference category). /

Conclusion: In older people with confirmed COVID-19, both intermediate and high frailty risk were associated with reduced survival compared to those with low frailty risk.
date: 2022-06-24
date_type: published
publisher: SPRINGER
official_url: https://doi.org/10.1007/s41999-022-00668-8
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1964066
doi: 10.1007/s41999-022-00668-8
medium: Print-Electronic
pii: 10.1007/s41999-022-00668-8
lyricists_name: Conroy, Simon
lyricists_id: SCONR64
actors_name: Conroy, Simon
actors_id: SCONR64
actors_role: owner
full_text_status: public
publication: European Geriatric Medicine
pages: 9
event_location: Switzerland
issn: 1878-7649
citation:        Maynou, Laia;    Owen, Rhiannon;    Konstant-Hambling, Rob;    Imam, Towhid;    Arkill, Suzanne;    Bertfield, Deborah;    Street, Andrew;         ... Conroy, Simon; + view all <#>        Maynou, Laia;  Owen, Rhiannon;  Konstant-Hambling, Rob;  Imam, Towhid;  Arkill, Suzanne;  Bertfield, Deborah;  Street, Andrew;  Abrams, Keith R;  Conroy, Simon;   - view fewer <#>    (2022)    The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people: a national cohort study.                   European Geriatric Medicine        10.1007/s41999-022-00668-8 <https://doi.org/10.1007/s41999-022-00668-8>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10153472/7/Conroy_The%20association%20between%20frailty%20risk%20and%20COVID-19-associated%20all-mortality%20in%20hospitalised%20older%20people%20a%20national%20cohort%20st.pdf