eprintid: 10153472 rev_number: 9 eprint_status: archive userid: 699 dir: disk0/10/15/34/72 datestamp: 2022-08-09 10:07:36 lastmod: 2022-08-09 10:07:36 status_changed: 2022-08-09 10:07:36 type: article metadata_visibility: show sword_depositor: 699 creators_name: Maynou, Laia creators_name: Owen, Rhiannon creators_name: Konstant-Hambling, Rob creators_name: Imam, Towhid creators_name: Arkill, Suzanne creators_name: Bertfield, Deborah creators_name: Street, Andrew creators_name: Abrams, Keith R creators_name: Conroy, Simon title: The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people: a national cohort study ispublished: inpress divisions: UCL divisions: D14 divisions: B02 keywords: COVID-19, Frailty, Acute hospital outcomes note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. abstract: Introduction: Frailty has emerged as an important construct to support clinical decision-making during the COVID-19 pandemic. However, doubts remain related to methodological limitations of published studies. / Methods: Retrospective cohort study of all people aged 75 + admitted to hospital in England between 1 March 2020 and 31 July 2021. COVID-19 and frailty risk were captured using International Classification of Disease-10 (ICD-10) diagnostic codes. We used the generalised gamma model to estimate accelerated failure time, reporting unadjusted and adjusted results. / Results: The cohort comprised 103,561 individuals, mean age 84.1, around half female, 82% were White British with a median of two comorbidities. Frailty risk was distributed approximately 20% low risk and 40% each at intermediate or high risk. In the unadjusted survival plots, 28-day mortality was almost 50% for those with an ICD-10 code of U071 (COVID-19 virus identified), and 25–35% for those with U072 (COVID-19 virus not identified). In the adjusted analysis, the accelerated failure time estimates for those with intermediate and high frailty risk were 0.63 (95% CI 0.58–0.68) and 0.67 (95% CI 0.62–0.72) fewer days alive respectively compared to those with low frailty risk with an ICD-10 diagnosis of U072 (reference category). / Conclusion: In older people with confirmed COVID-19, both intermediate and high frailty risk were associated with reduced survival compared to those with low frailty risk. date: 2022-06-24 date_type: published publisher: SPRINGER official_url: https://doi.org/10.1007/s41999-022-00668-8 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1964066 doi: 10.1007/s41999-022-00668-8 medium: Print-Electronic pii: 10.1007/s41999-022-00668-8 lyricists_name: Conroy, Simon lyricists_id: SCONR64 actors_name: Conroy, Simon actors_id: SCONR64 actors_role: owner full_text_status: public publication: European Geriatric Medicine pages: 9 event_location: Switzerland issn: 1878-7649 citation: Maynou, Laia; Owen, Rhiannon; Konstant-Hambling, Rob; Imam, Towhid; Arkill, Suzanne; Bertfield, Deborah; Street, Andrew; ... Conroy, Simon; + view all <#> Maynou, Laia; Owen, Rhiannon; Konstant-Hambling, Rob; Imam, Towhid; Arkill, Suzanne; Bertfield, Deborah; Street, Andrew; Abrams, Keith R; Conroy, Simon; - view fewer <#> (2022) The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people: a national cohort study. European Geriatric Medicine 10.1007/s41999-022-00668-8 <https://doi.org/10.1007/s41999-022-00668-8>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10153472/7/Conroy_The%20association%20between%20frailty%20risk%20and%20COVID-19-associated%20all-mortality%20in%20hospitalised%20older%20people%20a%20national%20cohort%20st.pdf