TY  - JOUR
VL  - 14
PB  - FRONTIERS MEDIA SA
Y1  - 2022/06/30/
A1  - Hurley, Michael J
A1  - Urra, Claudio
A1  - Garduno, B Maximiliano
A1  - Bruno, Agostino
A1  - Kimbell, Allison
A1  - Wilkinson, Brent
A1  - Marino-Buslje, Cristina
A1  - Ezquer, Marcelo
A1  - Ezquer, Fernando
A1  - Aburto, Pedro F
A1  - Poulin, Elie
A1  - Vasquez, Rodrigo A
A1  - Deacon, Robert
A1  - Avila, Ariel
A1  - Altimiras, Francisco
A1  - Whitney Vanderklish, Peter
A1  - Zampieri, Guido
A1  - Angione, Claudio
A1  - Constantino, Gabriele
A1  - Holmes, Todd C
A1  - Coba, Marcelo P
A1  - Xu, Xiangmin
A1  - Cogram, Patricia
N2  - The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.
AV  - public
JF  - Frontiers in Aging Neuroscience
EP  - 16
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
ID  - discovery10153335
TI  - Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Geriatrics & Gerontology
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  Alzheimer's disease
KW  -  aging
KW  -  genome
KW  -  APOE
KW  -  amyloids
KW  -  lipid droplets
KW  -  Octodon degus
KW  -  drug development
KW  -  GROWTH-FACTOR-I
KW  -  PATHOLOGY
KW  -  INSULIN
KW  -  METABOLISM
KW  -  NEURONS
KW  -  DYSREGULATION
KW  -  RECOGNITION
KW  -  VARIANTS
KW  -  DEMENTIA
KW  -  GENETICS
UR  - https://doi.org/10.3389/fnagi.2022.894994
ER  -