<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10153096> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/title> "Leukocyte Telomere Length Variability as a Potential Biomarker in Patients with PolyQ Diseases"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/abstract> "SCA1, SCA2, and SCA3 are the most common forms of SCAs among the polyglutamine disorders, which include Huntington's Disease (HD). We investigated the relationship between leukocyte telomere length (LTL) and the phenotype of SCA1, SCA2, and SCA3, comparing them with HD. The results showed that LTL was significantly reduced in SCA1 and SCA3 patients, while LTL was significantly longer in SCA2 patients. A significant negative relationship between LTL and age was observed in SCA1 but not in SCA2 subjects. LTL of SCA3 patients depend on both patient's age and disease duration. The number of CAG repeats did not affect LTL in the three SCAs. Since LTL is considered an indirect marker of an inflammatory response and oxidative damage, our data suggest that in SCA1 inflammation is present already at an early stage of disease similar to in HD, while in SCA3 inflammation and impaired antioxidative processes are associated with disease progression. Interestingly, in SCA2, contrary to SCA1 and SCA3, the length of leukocyte telomeres does not reduce with age. We have observed that SCAs and HD show a differing behavior in LTL for each subtype, which could constitute relevant biomarkers if confirmed in larger cohorts and longitudinal studies."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/date> "2022-08" .
<https://discovery.ucl.ac.uk/id/document/1503048> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/volume> "11" .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/issue> "8" .
<https://discovery.ucl.ac.uk/id/org/ext-16a556591fc6878b9a1e5626e5d3b570> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-16a556591fc6878b9a1e5626e5d3b570> <http://xmlns.com/foaf/0.1/name> "MDPI AG"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-16a556591fc6878b9a1e5626e5d3b570> .
<https://discovery.ucl.ac.uk/id/publication/ext-20763921> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20763921> <http://xmlns.com/foaf/0.1/name> "Antioxidants"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20763921> .
<https://discovery.ucl.ac.uk/id/publication/ext-20763921> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20763921> .
<https://discovery.ucl.ac.uk/id/publication/ext-20763921> <http://purl.org/ontology/bibo/issn> "20763921" .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d5191b185913de5672da64c7be5898bb> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-d5191b185913de5672da64c7be5898bb> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a02e21ce66c7664b2dbe29c2dd0b7baf> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-a02e21ce66c7664b2dbe29c2dd0b7baf> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-568b6f9c7c98f84249d838972ffdf72e> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-568b6f9c7c98f84249d838972ffdf72e> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4526d0af665b13b3949afe58c9ae2f48> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-4526d0af665b13b3949afe58c9ae2f48> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8bb5d4faccd87d7108a87e2bfae5d787> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-8bb5d4faccd87d7108a87e2bfae5d787> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dabf5a7c85728f35f4598fc4fa3135c4> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-dabf5a7c85728f35f4598fc4fa3135c4> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-de71cf7d94611a840e3c5c6b21eef41e> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-de71cf7d94611a840e3c5c6b21eef41e> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7981d5e4f4f72db49ae03c0688acd197> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-7981d5e4f4f72db49ae03c0688acd197> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-91cdd8d330cbe451dca8f8f4decc8c46> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-91cdd8d330cbe451dca8f8f4decc8c46> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-218f385ceb1d1853f37696dcc063cfc2> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-218f385ceb1d1853f37696dcc063cfc2> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cdedc92e8cf35105bda9979799a1d54a> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-cdedc92e8cf35105bda9979799a1d54a> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ab45b70fe3f10f887739764bba8e2e6d> .
<https://discovery.ucl.ac.uk/id/eprint/10153096> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10153096#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10153096#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-ab45b70fe3f10f887739764bba8e2e6d> .
<https://discovery.ucl.ac.uk/id/person/ext-a02e21ce66c7664b2dbe29c2dd0b7baf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a02e21ce66c7664b2dbe29c2dd0b7baf> <http://xmlns.com/foaf/0.1/givenName> "Liana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a02e21ce66c7664b2dbe29c2dd0b7baf> <http://xmlns.com/foaf/0.1/familyName> "Veneziano"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a02e21ce66c7664b2dbe29c2dd0b7baf> <http://xmlns.com/foaf/0.1/name> "Liana Veneziano"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cdedc92e8cf35105bda9979799a1d54a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cdedc92e8cf35105bda9979799a1d54a> <http://xmlns.com/foaf/0.1/givenName> "Rosa Maria"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cdedc92e8cf35105bda9979799a1d54a> <http://xmlns.com/foaf/0.1/familyName> "Corbo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cdedc92e8cf35105bda9979799a1d54a> <http://xmlns.com/foaf/0.1/name> "Rosa Maria Corbo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7981d5e4f4f72db49ae03c0688acd197> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7981d5e4f4f72db49ae03c0688acd197> <http://xmlns.com/foaf/0.1/givenName> "Nita"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7981d5e4f4f72db49ae03c0688acd197> <http://xmlns.com/foaf/0.1/familyName> "Solanky"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7981d5e4f4f72db49ae03c0688acd197> <http://xmlns.com/foaf/0.1/name> "Nita Solanky"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8bb5d4faccd87d7108a87e2bfae5d787> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8bb5d4faccd87d7108a87e2bfae5d787> <http://xmlns.com/foaf/0.1/givenName> "Elide"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8bb5d4faccd87d7108a87e2bfae5d787> <http://xmlns.com/foaf/0.1/familyName> "Mantuano"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8bb5d4faccd87d7108a87e2bfae5d787> <http://xmlns.com/foaf/0.1/name> "Elide Mantuano"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de71cf7d94611a840e3c5c6b21eef41e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-de71cf7d94611a840e3c5c6b21eef41e> <http://xmlns.com/foaf/0.1/givenName> "Gianmarco"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de71cf7d94611a840e3c5c6b21eef41e> <http://xmlns.com/foaf/0.1/familyName> "Bellucci"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de71cf7d94611a840e3c5c6b21eef41e> <http://xmlns.com/foaf/0.1/name> "Gianmarco Bellucci"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-218f385ceb1d1853f37696dcc063cfc2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-218f385ceb1d1853f37696dcc063cfc2> <http://xmlns.com/foaf/0.1/givenName> "Ginevra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-218f385ceb1d1853f37696dcc063cfc2> <http://xmlns.com/foaf/0.1/familyName> "Zanni"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-218f385ceb1d1853f37696dcc063cfc2> <http://xmlns.com/foaf/0.1/name> "Ginevra Zanni"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d5191b185913de5672da64c7be5898bb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d5191b185913de5672da64c7be5898bb> <http://xmlns.com/foaf/0.1/givenName> "Daniela"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d5191b185913de5672da64c7be5898bb> <http://xmlns.com/foaf/0.1/familyName> "Scarabino"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d5191b185913de5672da64c7be5898bb> <http://xmlns.com/foaf/0.1/name> "Daniela Scarabino"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-568b6f9c7c98f84249d838972ffdf72e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-568b6f9c7c98f84249d838972ffdf72e> <http://xmlns.com/foaf/0.1/givenName> "Alessia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-568b6f9c7c98f84249d838972ffdf72e> <http://xmlns.com/foaf/0.1/familyName> "Fiore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-568b6f9c7c98f84249d838972ffdf72e> <http://xmlns.com/foaf/0.1/name> "Alessia Fiore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-91cdd8d330cbe451dca8f8f4decc8c46> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-91cdd8d330cbe451dca8f8f4decc8c46> <http://xmlns.com/foaf/0.1/givenName> "Maria"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-91cdd8d330cbe451dca8f8f4decc8c46> <http://xmlns.com/foaf/0.1/familyName> "Morello"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-91cdd8d330cbe451dca8f8f4decc8c46> <http://xmlns.com/foaf/0.1/name> "Maria Morello"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dabf5a7c85728f35f4598fc4fa3135c4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dabf5a7c85728f35f4598fc4fa3135c4> <http://xmlns.com/foaf/0.1/givenName> "Hector"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dabf5a7c85728f35f4598fc4fa3135c4> <http://xmlns.com/foaf/0.1/familyName> "Garcia-Moreno"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dabf5a7c85728f35f4598fc4fa3135c4> <http://xmlns.com/foaf/0.1/name> "Hector Garcia-Moreno"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4526d0af665b13b3949afe58c9ae2f48> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4526d0af665b13b3949afe58c9ae2f48> <http://xmlns.com/foaf/0.1/givenName> "Suran"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4526d0af665b13b3949afe58c9ae2f48> <http://xmlns.com/foaf/0.1/familyName> "Nethisinghe"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4526d0af665b13b3949afe58c9ae2f48> <http://xmlns.com/foaf/0.1/name> "Suran Nethisinghe"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ab45b70fe3f10f887739764bba8e2e6d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ab45b70fe3f10f887739764bba8e2e6d> <http://xmlns.com/foaf/0.1/givenName> "Paola"^^<http://www.w3.org/2001/XMLSchema#string> .
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