eprintid: 10153042
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/30/42
datestamp: 2022-08-02 10:15:14
lastmod: 2022-08-02 10:15:14
status_changed: 2022-08-02 10:15:14
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Moulinet, Ines
creators_name: Touron, Edelweiss
creators_name: Mezenge, Florence
creators_name: Dautricourt, Sophie
creators_name: de la Sayette, Vincent
creators_name: Vivien, Denis
creators_name: Marchant, Natalie L
creators_name: Poisnel, Geraldine
creators_name: Chetelat, Gael
title: Depressive Symptoms Have Distinct Relationships With Neuroimaging Biomarkers Across the Alzheimer's Clinical Continuum
ispublished: pub
divisions: C07
divisions: FH5
divisions: B02
divisions: UCL
divisions: D79
keywords: Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Neurosciences, Neurosciences & Neurology, Alzheimer's disease, amyloid deposition, cognition, depressive symptoms, anxiety, glucose metabolism, subjective cognitive decline, gray matter, MILD COGNITIVE IMPAIRMENT, POSITRON-EMISSION-TOMOGRAPHY, SUBJECTIVE MEMORY COMPLAINTS, CORTICAL AMYLOID DEPOSITION, QUALITY-OF-LIFE, NEUROPSYCHIATRIC SYMPTOMS, OLDER-ADULTS, MATTER HYPOMETABOLISM, PSYCHIATRIC-SYMPTOMS, BEHAVIORAL SYMPTOMS
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abstract: Background: Depressive and anxiety symptoms are frequent in Alzheimer’s disease and associated with increased risk of developing Alzheimer’s disease in older adults. We sought to examine their relationships to Alzheimer’s disease biomarkers across the preclinical and clinical stages of the disease. Method: Fifty-six healthy controls, 35 patients with subjective cognitive decline and 56 amyloid-positive cognitively impaired patients on the Alzheimer’s continuum completed depression and anxiety questionnaires, neuropsychological tests and neuroimaging assessments. We performed multiple regressions in each group separately to assess within group associations of depressive and anxiety symptoms with either cognition (global cognition and episodic memory) or neuroimaging data (gray matter volume, glucose metabolism and amyloid load). Results: Depressive symptoms, but not anxiety, were higher in patients with subjective cognitive decline and cognitively impaired patients on the Alzheimer’s continuum compared to healthy controls. Greater depressive symptoms were associated with higher amyloid load in subjective cognitive decline patients, while they were related to higher cognition and glucose metabolism, and to better awareness of cognitive difficulties, in cognitively impaired patients on the Alzheimer’s continuum. In contrast, anxiety symptoms were not associated with brain integrity in any group. Conclusion: These data show that more depressive symptoms are associated with greater Alzheimer’s disease biomarkers in subjective cognitive decline patients, while they reflect better cognitive deficit awareness in cognitively impaired patients on the Alzheimer’s continuum. Our findings highlight the relevance of assessing and treating depressive symptoms in the preclinical stages of Alzheimer’s disease.
date: 2022-06-20
date_type: published
publisher: FRONTIERS MEDIA SA
official_url: https://doi.org/10.3389/fnagi.2022.899158
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1965226
doi: 10.3389/fnagi.2022.899158
medium: Electronic-eCollection
lyricists_name: Marchant, Natalie
lyricists_id: NLMAR24
actors_name: Marchant, Natalie
actors_id: NLMAR24
actors_role: owner
funding_acknowledgements: [Agence Nationale de la Recherche (LONGVIE, 2007) Association France Alzheimer et maladies apparentees AAP 2013]; [Fondation Plan Alzheimer (Alzheimer Plan 2008-2012)]; [Institut National de la Sante et de la Recherche Medicale (INSERM)]; 667696 [European Union's Horizon2020 Research and Innovation Program]; PHRCN 2011-A01493-38 [Programme Hospitalier de Recherche Clinique]; PHRCN 2012 12-006-0347 [Programme Hospitalier de Recherche Clinique]; [Region Basse-Normandie]; [French Ministere de l'Enseignement Superieur et de la Recherche]; [French ministerial scholarship and University grant for traveling and attending a scientific meeting in Berlin]; [Inserm]; [European Union Horizon 2020]; [Alzheimer's Society]; [European Union Horizon 2020 and Medical Research Council]; [European Union's Horizon 2020 research and innovation programme]; 667696 [EU's Horizon 2020 research and innovation programme]; [Fondation d'entreprise MMA des Entrepreneurs du Futur]; [Fondation Alzheimer]; [Programme Hospitalier de Recherche Clinique]; [Region Normandie]; [Association France Alzheimer et maladies apparentees]; [Fondation Vaincre Alzheimer]
full_text_status: public
publication: Frontiers in Aging Neuroscience
volume: 14
article_number: 899158
pages: 12
event_location: Switzerland
citation:        Moulinet, Ines;    Touron, Edelweiss;    Mezenge, Florence;    Dautricourt, Sophie;    de la Sayette, Vincent;    Vivien, Denis;    Marchant, Natalie L;         ... Chetelat, Gael; + view all <#>        Moulinet, Ines;  Touron, Edelweiss;  Mezenge, Florence;  Dautricourt, Sophie;  de la Sayette, Vincent;  Vivien, Denis;  Marchant, Natalie L;  Poisnel, Geraldine;  Chetelat, Gael;   - view fewer <#>    (2022)    Depressive Symptoms Have Distinct Relationships With Neuroimaging Biomarkers Across the Alzheimer's Clinical Continuum.                   Frontiers in Aging Neuroscience , 14     , Article 899158.  10.3389/fnagi.2022.899158 <https://doi.org/10.3389/fnagi.2022.899158>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10153042/1/Depressive%20Symptoms%20Have%20Distinct%20Relationships%20With%20Neuroimaging%20Biomarkers%20Across%20the%20Alzheimers%20Clinical%20Continuum.pdf