eprintid: 10152056
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/20/56
datestamp: 2022-07-14 09:52:04
lastmod: 2022-07-14 09:52:04
status_changed: 2022-07-14 09:52:04
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Filteau, Suzanne
creators_name: Kasonka, Lackson
creators_name: Wells, Jonathan CK
creators_name: Munthali, Grace
creators_name: Chisenga, Molly
creators_name: Rehman, Andrea Mary
title: Anthropometry, body composition, early growth and chronic disease risk factors among Zambian adolescents exposed or not to perinatal maternal HIV
ispublished: inpress
divisions: UCL
divisions: G25
divisions: D13
divisions: B02
keywords: HIV, Growth trajectory, Body composition, Chronic disease risk, Adolescent, HbA1c, Cohort
note: Copyright © Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
abstract: Early life exposures and growth patterns may affect long-term risk of chronic non-communicable diseases (NCD). We followed up in adolescence two Zambian cohorts (n 322) recruited in infancy to investigate how two early exposures - maternal HIV exposure without HIV infection (HEU) and early growth profile - were associated with later anthropometry, body composition, blood lipids, Hb and HbA1c, blood pressure and grip strength. Although in analyses controlled for age and sex, HEU children were thinner, but not shorter, than HIV-unexposed, uninfected (HUU) children, with further control for socio-demographic factors, these differences were not significant. HEU children had higher HDL-cholesterol than HUU children and marginally lower HbA1c but no other biochemical or clinical differences. We identified three early growth profiles - adequate growth, declining and malnourished - which tracked into adolescence when differences in anthropometry and body fat were still seen. In adolescence, the early malnourished group, compared with the adequate group, had lower blood TAG and higher HDL, lower grip strength (difference: -1·87 kg, 95 % CI -3·47, -0·27; P = 0·02) and higher HbA1c (difference: 0·5 %, 95 % CI 0·2, 0·9; P = 0·005). Lower grip strength and higher HbA1c suggest the early malnourished children could be at increased risk of NCD in later life. Including early growth profile in analyses of HIV exposure reduced the associations between HIV and outcomes. The results suggest that perinatal HIV exposure may have no long-term effects unless accompanied by poor early growth. Reducing the risk of young child malnutrition may lessen children's risk of later NCD.
date: 2022-06-13
date_type: published
publisher: CAMBRIDGE UNIV PRESS
official_url: https://doi.org/10.1017/S0007114522001775
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1963482
doi: 10.1017/S0007114522001775
medium: Print-Electronic
pii: S0007114522001775
lyricists_name: Wells, Jonathan
lyricists_id: JWELL04
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: E43032 [International Atomic Energy Agency]; [UK Medical Research Council (MRC)]; [UK Foreign, Commonwealth and Development Office (FCDO) under the MRC/DFID]; MR/R010161/1 [European Union]
full_text_status: public
publication: British Journal of Nutrition
pages: 12
event_location: England
issn: 0007-1145
citation:        Filteau, Suzanne;    Kasonka, Lackson;    Wells, Jonathan CK;    Munthali, Grace;    Chisenga, Molly;    Rehman, Andrea Mary;      (2022)    Anthropometry, body composition, early growth and chronic disease risk factors among Zambian adolescents exposed or not to perinatal maternal HIV.                   British Journal of Nutrition        10.1017/S0007114522001775 <https://doi.org/10.1017/S0007114522001775>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10152056/1/anthropometry-body-composition-early-growth-and-chronic-disease-risk-factors-among-zambian-adolescents-exposed-or-not-to-perinatal-maternal-hiv.pdf