eprintid: 10152023
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/15/20/23
datestamp: 2022-07-14 11:18:21
lastmod: 2022-07-14 11:18:21
status_changed: 2022-07-14 11:18:21
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Lloyd, Kelly E
creators_name: Hall, Louise H
creators_name: Ziegler, Lucy
creators_name: Smith, Samuel G
title: Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study
ispublished: pub
divisions: C10
divisions: G88
divisions: B02
divisions: UCL
divisions: D16
keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Preventive therapy, Chemoprevention, Decision-making, Cancer worry
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abstract: PURPOSE: Women's worry about developing breast cancer may influence their decision to use preventive therapy. However, the direction of this relationship has been questioned. We prospectively investigated the relationship between breast cancer worry and uptake of preventive therapy. The socio-demographic and clinical factors associated with high breast cancer worry were also investigated. METHODS: Women at increased risk of developing breast cancer were recruited from clinics across England (n = 408). Participants completed a survey on their breast cancer worry, socio-demographic and clinical factors. Uptake of tamoxifen was recorded at 3 months (n = 258 women, 63.2%). Both primary and sensitivity analyses were conducted using different classifications of low, medium and high worry. RESULTS: 39.5% of respondents reported medium breast cancer worry at baseline and 21.2% reported high worry. Ethnic minority women were more likely to report high worry than white women (OR = 3.02, 95%CI 1.02, 8.91, p = 0.046). Women educated below degree level were more likely to report high worry than those with higher education (OR = 2.29, 95%CI 1.28, 4.09, p = 0.005). No statistically significant association was observed between worry and uptake. In the primary analysis, fewer respondents with medium worry at baseline initiated tamoxifen (low worry = 15.5%, medium = 13.5%, high = 15.7%). In the sensitivity analysis, participants with medium worry reported the highest uptake of tamoxifen (19.7%). CONCLUSIONS: No association was observed between worry and uptake, although the relationship was affected by the categorisation of worry. Standardised reporting of the classification of worry is warranted to allow transparent comparisons across cohorts.
date: 2021-03-17
date_type: published
publisher: SPRINGER
official_url: https://doi.org/10.1007/s10549-021-06183-x
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1965439
doi: 10.1007/s10549-021-06183-x
pii: 10.1007/s10549-021-06183-x
lyricists_name: Vaidya, Jayant
lyricists_id: JSVAI17
actors_name: Vaidya, Jayant
actors_id: JSVAI17
actors_role: owner
funding_acknowledgements: C42785/A17965 [Cancer Research UK]; [Yorkshire Cancer Research University Academic Fellowship]; [Economic and Social Research Council]
full_text_status: public
publication: Breast Cancer Research and Treatment
volume: 188
number: 3
pagerange: 703-712
pages: 10
event_location: Netherlands
citation:        Lloyd, Kelly E;    Hall, Louise H;    Ziegler, Lucy;    Smith, Samuel G;      (2021)    Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study.                   Breast Cancer Research and Treatment , 188  (3)   pp. 703-712.    10.1007/s10549-021-06183-x <https://doi.org/10.1007/s10549-021-06183-x>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10152023/1/Lloyd2021_Article_BreastCancerWorryInHigher-risk.pdf