TY  - JOUR
UR  - https://doi.org/10.1007/s00221-022-06327-5
SP  - 1241
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  Short latency afferent inhibition
KW  -  Amplitude measurement
KW  -  Threshold-tracking
KW  -  Variability
KW  -  TRANSCRANIAL MAGNETIC STIMULATION
KW  -  INTERVAL INTRACORTICAL INHIBITION
KW  -  MOTOR CORTEX
KW  -  PLASTICITY
TI  - Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods
N2  - Short-latency afferent inhibition (SAI), which is conventionally measured as a reduction in motor evoked potential amplitude (A-SAI), is of clinical interest as a potential biomarker for cognitive impairment. Since threshold-tracking has some advantages for clinical studies of short-interval cortical inhibition, we have compared A-SAI with a threshold-tracking alternative method (T-SAI). In the T-SAI method, inhibition was calculated by tracking the required TMS intensity for the targeted MEP amplitude (200 uV) both for the test (TMS only) and paired (TMS and peripheral stimulation) stimuli. A-SAI and T-SAI were recorded from 31 healthy subjects using ten stimuli at each of 12 inter-stimulus intervals, once in the morning and again in the afternoon. There were no differences between morning and afternoon recordings. When A-SAI was normalized by log conversion it was closely related to T-SAI. Between subjects, variability was similar for the two techniques, but within-subject variability was significantly smaller for normalized A-SAI. Conventional amplitude measurements appear more sensitive for detecting changes within-subjects, such as in interventional studies, but threshold-tracking may be as sensitive as detecting abnormal SAI in a patient.
VL  - 240
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
ID  - discovery10151975
AV  - public
EP  - 1247
JF  - Experimental Brain Research
IS  - 4
Y1  - 2022/02/22/
PB  - Springer Science and Business Media LLC
A1  - Cengiz, Bülent
A1  - Boran, H Evren
A1  - Alayd?n, Halil Can
A1  - Tankisi, Hatice
A1  - Samusyte, Gintaute
A1  - Howells, James
A1  - Koltzenburg, Martin
A1  - Bostock, Hugh
ER  -