eprintid: 10151769 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/15/17/69 datestamp: 2022-07-08 09:42:01 lastmod: 2022-07-08 09:42:01 status_changed: 2022-07-08 09:42:01 type: article metadata_visibility: show sword_depositor: 699 creators_name: Lanka, Pranav creators_name: Yang, Lin creators_name: Orive-Miguel, David creators_name: Veesa, Joshua Deepak creators_name: Tagliabue, Susanna creators_name: Sudakou, Aleh creators_name: Samaei, Saeed creators_name: Forcione, Mario creators_name: Kovacsova, Zuzana creators_name: Behera, Anurag creators_name: Gladytz, Thomas creators_name: Grosenick, Dirk creators_name: Hervé, Lionel creators_name: Durduran, Turgut creators_name: Bejm, Karolina creators_name: Morawiec, Magdalena creators_name: Kacprzak, Michał creators_name: Sawosz, Piotr creators_name: Gerega, Anna creators_name: Liebert, Adam creators_name: Belli, Antonio creators_name: Tachtsidis, Ilias creators_name: Lange, Frédéric creators_name: Bale, Gemma creators_name: Baratelli, Luca creators_name: Gioux, Sylvain creators_name: Alexander, Kalyanov creators_name: Wolf, Martin creators_name: Sekar, Sanathana Konugolu Venkata creators_name: Zanoletti, Marta creators_name: Pirovano, Ileana creators_name: Lacerenza, Michele creators_name: Qiu, Lina creators_name: Ferocino, Edoardo creators_name: Maffeis, Giulia creators_name: Amendola, Caterina creators_name: Colombo, Lorenzo creators_name: Frabasile, Lorenzo creators_name: Levoni, Pietro creators_name: Buttafava, Mauro creators_name: Renna, Marco creators_name: Di Sieno, Laura creators_name: Re, Rebecca creators_name: Farina, Andrea creators_name: Spinelli, Lorenzo creators_name: Dalla Mora, Alberto creators_name: Contini, Davide creators_name: Taroni, Paola creators_name: Tosi, Alberto creators_name: Torricelli, Alessandro creators_name: Dehghani, Hamid creators_name: Wabnitz, Heidrun creators_name: Pifferi, Antonio title: Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise ispublished: pub divisions: C05 divisions: F42 divisions: B04 divisions: UCL keywords: absorption, diffuse optics, near-infrared spectroscopy, phantom, scattering, Laboratories, Optics and Photonics, Phantoms, Imaging, Reproducibility of Results, Spectrum Analysis note: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). abstract: SIGNIFICANCE: Multi-laboratory initiatives are essential in performance assessment and standardization-crucial for bringing biophotonics to mature clinical use-to establish protocols and develop reference tissue phantoms that all will allow universal instrument comparison. AIM: The largest multi-laboratory comparison of performance assessment in near-infrared diffuse optics is presented, involving 28 instruments and 12 institutions on a total of eight experiments based on three consolidated protocols (BIP, MEDPHOT, and NEUROPT) as implemented on three kits of tissue phantoms. A total of 20 synthetic indicators were extracted from the dataset, some of them defined here anew. APPROACH: The exercise stems from the Innovative Training Network BitMap funded by the European Commission and expanded to include other European laboratories. A large variety of diffuse optics instruments were considered, based on different approaches (time domain/frequency domain/continuous wave), at various stages of maturity and designed for different applications (e.g., oximetry, spectroscopy, and imaging). RESULTS: This study highlights a substantial difference in hardware performances (e.g., nine decades in responsivity, four decades in dark count rate, and one decade in temporal resolution). Agreement in the estimates of homogeneous optical properties was within 12% of the median value for half of the systems, with a temporal stability of <5 % over 1 h, and day-to-day reproducibility of <3 % . Other tests encompassed linearity, crosstalk, uncertainty, and detection of optical inhomogeneities. CONCLUSIONS: This extensive multi-laboratory exercise provides a detailed assessment of near-infrared Diffuse optical instruments and can be used for reference grading. The dataset-available soon in an open data repository-can be evaluated in multiple ways, for instance, to compare different analysis tools or study the impact of hardware implementations. date: 2022-07 date_type: published publisher: SPIE-Intl Soc Optical Eng official_url: https://doi.org/10.1117/1.JBO.27.7.074716 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1963015 doi: 10.1117/1.JBO.27.7.074716 medium: Print pii: JBO-210373SSR lyricists_name: Lange, Frederic lyricists_id: FLANG91 actors_name: Lange, Frederic actors_id: FLANG91 actors_role: owner full_text_status: public publication: Journal of Biomedical Optics volume: 27 number: 7 article_number: 074716 event_location: United States citation: Lanka, Pranav; Yang, Lin; Orive-Miguel, David; Veesa, Joshua Deepak; Tagliabue, Susanna; Sudakou, Aleh; Samaei, Saeed; ... Pifferi, Antonio; + view all <#> Lanka, Pranav; Yang, Lin; Orive-Miguel, David; Veesa, Joshua Deepak; Tagliabue, Susanna; Sudakou, Aleh; Samaei, Saeed; Forcione, Mario; Kovacsova, Zuzana; Behera, Anurag; Gladytz, Thomas; Grosenick, Dirk; Hervé, Lionel; Durduran, Turgut; Bejm, Karolina; Morawiec, Magdalena; Kacprzak, Michał; Sawosz, Piotr; Gerega, Anna; Liebert, Adam; Belli, Antonio; Tachtsidis, Ilias; Lange, Frédéric; Bale, Gemma; Baratelli, Luca; Gioux, Sylvain; Alexander, Kalyanov; Wolf, Martin; Sekar, Sanathana Konugolu Venkata; Zanoletti, Marta; Pirovano, Ileana; Lacerenza, Michele; Qiu, Lina; Ferocino, Edoardo; Maffeis, Giulia; Amendola, Caterina; Colombo, Lorenzo; Frabasile, Lorenzo; Levoni, Pietro; Buttafava, Mauro; Renna, Marco; Di Sieno, Laura; Re, Rebecca; Farina, Andrea; Spinelli, Lorenzo; Dalla Mora, Alberto; Contini, Davide; Taroni, Paola; Tosi, Alberto; Torricelli, Alessandro; Dehghani, Hamid; Wabnitz, Heidrun; Pifferi, Antonio; - view fewer <#> (2022) Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise. Journal of Biomedical Optics , 27 (7) , Article 074716. 10.1117/1.JBO.27.7.074716 <https://doi.org/10.1117/1.JBO.27.7.074716>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10151769/1/074716_1.pdf